The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation [PDF]
, 2018 The expression of the long noncoding RNA HOTAIR (HOX Transcript Antisense Intergenic RNA) is largely deregulated in epithelial cancers and positively correlates with poor prognosis and progression of hepatocellular carcinoma and gastrointestinal cancers.
A Busanello +51 more
core +1 more source
Deficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arrest [PDF]
, 2015 TGFbeta is critical to control hepatocyte proliferation by inducing G1-growth arrest through multiple pathways leading to inhibition of E2F transcription activity.
Bellamy, Christopher O +4 more
core +1 more source
Simulated microgravity promotes the formation of tridimensional cultures and stimulates pluripotency and a glycolytic metabolism in human hepatic and biliary tree stem/progenitor cells [PDF]
, 2019 Many pivotal biological cell processes are affected by gravity. The aim of our study was to evaluate biological and functional effects, differentiation potential and exo-metabolome profile of simulated microgravity (SMG) on human hepatic cell line (HepG2)
Alvaro, Domenico +14 more
core +2 more sources
A review on autosomal dominant tubulointerstitial kidney disease
Nefrología (English Edition), 2017 In recent years there has been a reclassification of hereditary tubulointerstitial renal diseases. The old concepts of nephronoptisis or medullary cystic disease have been reordered based on the discovery of new genes.
Nadia Ayasreh +4 more
doaj +1 more source
HGF modulates actin cytoskeleton remodeling and contraction in testicular myoid cells [PDF]
, 2015 The presence of the HGF/Met system in the testicular myoid cells was first discovered by our group. However, the physiological role of this pathway remains poorly understood. We previously reported that HGF increases uPA secretion and TGF-β activation in
Angela, Catizone +6 more
core +1 more source
Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis [PDF]
, 2002 Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest group of malignant tumors. Colorectal cancer is one of the most common neoplastic diseases in Western countries and one of the leading causes of ...
Bommer, G., Göke, B., Kolligs, F. T.
core +2 more sources
PLoS ONE, 2014 Dimerization of hypoxia-inducible factor-1 beta (HIF-1β) [aryl hydrocarbon receptor nuclear translocator (ARNT)] with HIF-1α is involved in various aspects of cancer biology, including proliferation and survival under hypoxic conditions.
Sung Hoon Choi +10 more
doaj +1 more source
Genetic markers of inflammation may not contribute to metabolic traits in Mexican children [PDF]
PeerJ, 2016 Background: Low-grade chronic inflammation is a common feature of obesity and its cardio-metabolic complications. However, little is known about a possible causal role of inflammation in metabolic disorders. Mexico is among the countries with the highest
Neeti Vashi +7 more
doaj +2 more sources
Transcriptional regulation of the ABCC6 gene and the background of impaired function of missense disease-causing mutations. [PDF]
, 2013 The human ATP-binding cassette family C member 6 (ABCC6) gene encodes an ABC transporter protein expressed primarily in the liver and to a lesser extent in the kidneys and the intestines.
Arányi, Tamás +5 more
core +1 more source
SDF-1 alone and in co-operation with HGF regulates biology of human cervical carcinoma cells.
Folia Histochemica et Cytobiologica, 2006 Stromal Derived Factor-1 (SDF-1)-CXCR4 axis plays a pivotal role in biology and metastasis of several tumors. The aim of this study was to see if SDF-1 alone or in combination with Hepatocyte Growth Factor (HGF) affects biology of human cervical ...
Alfred B Jenson +5 more
doaj +1 more source