Results 31 to 40 of about 41,374 (252)
Delineating the role of Hepatocyte Nuclear Factor 1 Beta (HNF1B) transcript variants in prostate cancer [PDF]
, 2020 Genome Wide Association Studies (GWAS) has identified HNF1B located at chromosome 17q12 as foremost risk gene for prostate cancer susceptibility in multi-ethnic populations. This thesis characterises the HNF1B transcript variants along with defining their expression pattern and functional attributes in prostate cancer.
openaire +2 more sources
Journal of the Pakistan Medical AssociationCisplatin resistance in ovarian cancer, particularly in ovarian clear cell carcinoma, involves intricate mechanisms related to oxidative stress, deoxyribonucleic acid repair, and cell cycle.
Wen Deng +5 more
doaj +1 more source
SDF-1 alone and in co-operation with HGF regulates biology of human cervical carcinoma cells.
Folia Histochemica et Cytobiologica, 2006 Stromal Derived Factor-1 (SDF-1)-CXCR4 axis plays a pivotal role in biology and metastasis of several tumors. The aim of this study was to see if SDF-1 alone or in combination with Hepatocyte Growth Factor (HGF) affects biology of human cervical ...
Alfred B Jenson +5 more
doaj +1 more source
Genetic markers of inflammation may not contribute to metabolic traits in Mexican children [PDF]
PeerJ, 2016 Background: Low-grade chronic inflammation is a common feature of obesity and its cardio-metabolic complications. However, little is known about a possible causal role of inflammation in metabolic disorders. Mexico is among the countries with the highest
Neeti Vashi +7 more
doaj +2 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Contrasting Insulin Sensitivity of Endogenous Glucose Production Rate in Subjects With Hepatocyte Nuclear Factor-1β and -1α Mutations [PDF]
Diabetes, 2006 Heterozygous mutations in the transcription factors hepatocyte nuclear factor (HNF)-1α and -1β result in MODY (maturity-onset diabetes of the young). Despite structural similarity between HNF-1α and -1β, HNF-1β mutation carriers have hyperinsulinemia, whereas HNF-1α mutation carriers have normal or reduced insulin concentrations.
Brackenridge, Anna +5 more
openaire +4 more sources
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Synergistic curative effect of Boswellic acid and Cisplatin against Diethyl nitrosamine -induced hepatocellular carcinoma [PDF]
Benha Veterinary Medical Journal, 2019 Hepatocellular carcinoma (HCC) is a primary malignancy of hepatocyte. Boswellic acids are the effective components of gum resin of Boswellia serrata, which have anti-inflammatory properties.
somaya Mansour +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source