Results 21 to 30 of about 41,374 (252)

Insulin-Like Growth Factor I (IGF-I) Expressed from an AAV1 Vector Leads to a Complete Reversion of Liver Cirrhosis in Rats. [PDF]

PLoS ONE, 2016
IGF-I modulates liver tissue homeostasis. It is produced by hepatocytes and signals within the liver through IGF-I receptor expressed on hepatic stellate cells (HSCs). Liver cirrhosis is characterized by marked IGF-I deficiency.
Luciano Sobrevals, Mónica Enguita, Jorge Quiroga, Jesús Prieto, Puri Fortes   +4 more
doaj   +1 more source

Germline hepatocyte nuclear factor 1α and 1β mutations in renal cell carcinomas [PDF]

Human Molecular Genetics, 2005
Mutations in one copy of the hepatocyte nuclear factors (HNF) 1alpha and 1beta homeodomain containing transcription factors predispose the carrier to maturity-onset diabetes of the young (MODY) types 3 and 5, respectively. Moreover, previous identification of biallelic inactivation of HNF1alpha in hepatocellular adenoma identified its tumor suppressor ...
Rebouissou, Sandra, Vasiliu, Viorel, Thomas, Cristel, Bellanne-Chantelot, Christine, Bui, Hung, Chretien, Yves, Timsit, José, Rosty, Christophe, Laurent-Puig, Pierre, Chauveau, Dominique, Zucman-Rossi, Jessica   +10 more
openaire   +5 more sources

The Expression of Transcription Factors in Fetal Lamb Kidney

Journal of Developmental Biology, 2021
(1) Background: Renal development involves frequent expression and loss of transcription factors, resulting in the activation of genes. Wilms’ tumor 1 (WT1), hepatocyte nuclear factor-1-beta (HNF1β), and paired box genes 2 and 8 (Pax2 and Pax8) play an ...
Yuri Nishiya, Kohei Kawaguchi, Kosuke Kudo, Takuya Kawaguchi, Juma Obayashi, Kunihide Tanaka, Kei Ohyama, Hideki Nagae, Shigeyuki Furuta, Yasuji Seki, Junki Koike, Kevin C. Pringle, Hiroaki Kitagawa   +12 more
doaj   +1 more source

The Liver Protection Effects of Maltol, a Flavoring Agent, on Carbon Tetrachloride-Induced Acute Liver Injury in Mice via Inhibiting Apoptosis and Inflammatory Response

Molecules, 2018
The purpose of this research was to evaluate whether maltol could protect from hepatic injury induced by carbon tetrachloride (CCl4) in vivo by inhibition of apoptosis and inflammatory responses. In this work, maltol was administered at a level of 100 mg/
Wei Liu, Zi Wang, Jin-gang Hou, Yan-dan Zhou, Yu-fang He, Shuang Jiang, Ying-ping Wang, Shen Ren, Wei Li   +8 more
doaj   +1 more source

Comprehensive quantitative analysis of alternative splicing variants reveals the HNF1B mRNA splicing pattern in various tumour and non-tumour tissues

Scientific Reports, 2022
Hepatocyte nuclear factor-1-beta (HNF1B) is a transcription factor and putative biomarker of solid tumours. Recently, we have revealed a variety of HNF1B mRNA alternative splicing variants (ASVs) with unknown, but potentially regulatory, functions.
Jan Hojny, Romana Michalkova, Eva Krkavcova, Quang Hiep Bui, Michaela Bartu, Kristyna Nemejcova, Marta Kalousova, Petra Kleiblova, Pavel Dundr, Ivana Struzinska   +9 more
doaj   +1 more source

Cooperation Between the NRF2 Pathway and Oncogenic β‐catenin During HCC Tumorigenesis

Hepatology Communications, 2021
CTNNB1 (catenin beta 1)–mutated hepatocellular carcinomas (HCCs) account for a large proportion of human HCCs. They display high levels of respiratory chain activity.
Mathilde Savall, Nadia Senni, Isabelle Lagoutte, Pierre Sohier, Renaud Dentin, Beatrice Romagnolo, Christine Perret, Pascale Bossard   +7 more
doaj   +1 more source

Hepatocyte nuclear factor-1 beta protects endometriotic cells against apoptotic cell death by up-regulating the expression of antiapoptotic genes† [PDF]

Biology of Reproduction, 2019
AbstractThe overexpression of hepatocyte nuclear factor-1 beta (HNF1β) in endometriotic lesion has been demonstrated. However, the role of HNF1β in endometriosis remains largely unknown. Human endometriotic 12Z cells showed higher level of HNF1β when compared with normal endometrial HES cells. In human endometriotic 12Z cells, HNF1β knockdown increased
Umma Hafsa, Preya, Jeong-Hwa, Woo, Youn Seok, Choi, Jung-Hye, Choi   +3 more
openaire   +2 more sources

MODY: Strategies for a unique form of diabetes

Journal of Education and Health Promotion
Maturity-onset diabetes of the young (MODY) is a monogenic, autosomal dominant form of diabetes that typically presents before the age of 25. It is caused by mutations in single genes involved in insulin production and glucose regulation, leading to ...
Ram K. Garg
doaj   +1 more source

A review on autosomal dominant tubulointerstitial kidney disease

Nefrología (English Edition), 2017
In recent years there has been a reclassification of hereditary tubulointerstitial renal diseases. The old concepts of nephronoptisis or medullary cystic disease have been reordered based on the discovery of new genes.
Nadia Ayasreh, Rosa Miquel, Ana Matamala, Elisabet Ars, Roser Torra   +4 more
doaj   +1 more source

Silencing of hypoxia-inducible factor-1β induces anti-tumor effects in hepatoma cell lines under tumor hypoxia.

PLoS ONE, 2014
Dimerization of hypoxia-inducible factor-1 beta (HIF-1β) [aryl hydrocarbon receptor nuclear translocator (ARNT)] with HIF-1α is involved in various aspects of cancer biology, including proliferation and survival under hypoxic conditions.
Sung Hoon Choi, Ae Ri Chung, Wonseok Kang, Jun Yong Park, Mi Sol Lee, Shin Won Hwang, Do Young Kim, Seung Up Kim, Sang Hoon Ahn, Seungtaek Kim, Kwang-Hyub Han   +10 more
doaj   +1 more source