Results 11 to 20 of about 41,374 (252)

Hepatocyte nuclear factor 1β controls nephron tubular development [PDF]

Development, 2013
Nephron morphogenesis is a complex process that generates blood-filtration units (glomeruli) connected to extremely long and patterned tubular structures. Hepatocyte nuclear factor 1β (HNF1β) is a divergent homeobox transcription factor that is expressed in kidney from the first steps of nephrogenesis.
Massa, F., Garbay, S., Bouvier, R., Sugitani, Y., Noda, T., Gubler, M.-C., Heidet, L., Pontoglio, M., Fischer, E.   +8 more
openaire   +2 more sources

Human hepatocyte nuclear factor-1β (HNF1B) 1968A/G polymorphism [PDF]

Journal of Human Genetics, 2000
We found a novel A-->G change at nucleotide 1968 within the 3'-untranslated region of the HNF1B gene encoding the hepatocyte nuclear factor-1 beta. The HNF1B 1968A/G polymorphism could be detected by digestion with endonuclease MspI. The frequency of the HNF1B 1968G allele was 0.060 in Caucasians and 0.129 in Canadian Oji-Cree.
H, Cao, R A, Hegele
openaire   +2 more sources

Serum transferrin as a biomarker of hepatocyte nuclear factor 4 alpha activity and hepatocyte function in liver diseases

BMC Medicine, 2021
Background Serum transferrin levels represent an independent predictor of mortality in patients with liver failure. Hepatocyte nuclear factor 4 alpha (HNF4α) is a master regulator of hepatocyte functions.
Nurdan Guldiken, Josepmaria Argemi, Berivan Gurbuz, Stephen R. Atkinson, Martin Oliverius, Petr Fila, Karim Hamesch, Tony Bruns, Joaquín Cabezas, Juan J. Lozano, Jelena Mann, Sheng Cao, Philippe Mathurin, Vijay H. Shah, Christian Trautwein, Mark R. Thursz, Ramon Bataller, Pavel Strnad   +17 more
doaj   +1 more source

Failure to Thrive in a Middle-Aged Female: A Case of Congenital Incomplete Pancreas From a Rare Genetic Defect

Journal of Investigative Medicine High Impact Case Reports, 2023
Hepatocyte nuclear factor-1 beta (HNF1B) gene is predominantly expressed in the liver, kidney, lung, genitourinary tract, and pancreas. It is an important transcription factor that regulates pancreas development.
Onyinye Ugonabo MD, Turki Mohamed MD, Murad Kheetan MD, Ahmed Sherif MD   +3 more
doaj   +1 more source

A novel splice-site mutation of the HNF1B gene in a family with maturity onset diabetes of the young type 5 (MODY5)

Endocrinology, Diabetes & Metabolism Case Reports, 2020
Maturity-onset diabetes of the young (MODY) is a form of monogenic diabetes mellitus characterised by early onset and dominant inheritance. Delayed diagnosis or misdiagnosis as type 1 or type 2 diabetes mellitus is common. Definitive genetic diagnosis is
Yuki Fujita, Daisuke Tanaka, Hisato Tatsuoka, Miho Matsubara, Takanori Hyo, Yoshiyuki Hamamoto, Toshiyuki Komiya, Nobuya Inagaki, Yutaka Seino, Yuji Yamazaki   +9 more
doaj   +1 more source

Downhill Running-Based Overtraining Protocol Improves Hepatic Insulin Signaling Pathway without Concomitant Decrease of Inflammatory Proteins. [PDF]

PLoS ONE, 2015
The purpose of this study was to verify the effects of overtraining (OT) on insulin, inflammatory and gluconeogenesis signaling pathways in the livers of mice.
Alisson L da Rocha, Bruno C Pereira, José R Pauli, Dennys E Cintra, Claudio T de Souza, Eduardo R Ropelle, Adelino S R da Silva   +6 more
doaj   +1 more source

The Hepatocyte nuclear factor-1 alpha (HNF1A) gene is associated with fatness and loin muscle area in the pig

Animal, 2010
The significance of hepatocyte nuclear factors (HNFs) in β-cell development and function has been generally recognized in humans, as evidenced by their associations with cases of maturity onset diabetes of the young (MODY).
B. Fan, Z.-Q. Du, M.F. Rothschild
doaj   +1 more source

Update on clinical screening of maturity-onset diabetes of the young (MODY)

Diabetology & Metabolic Syndrome, 2020
Background Maturity-onset diabetes of the young (MODY) is the most common type of monogenic diabetes, being characterized by beta-cell disfunction, early onset, and autosomal dominant inheritance.
Renata Peixoto-Barbosa, André F. Reis, Fernando M. A. Giuffrida   +2 more
doaj   +1 more source

Hepatocyte Bcl-3 protects from death-receptor mediated apoptosis and subsequent acute liver failure

Cell Death and Disease, 2022
Acute liver failure (ALF) is a rare entity but exhibits a high mortality. The mechanisms underlying ALF are not completely understood. The present study explored the role of the hepatic B cell leukemia-3 (Bcl-3), a transcriptional regulator of nuclear ...
Nadine Gehrke, Marcus A. Wörns, Amrit Mann, Nadine Hövelmeyer, Ari Waisman, Beate K. Straub, Peter R. Galle, Jörn M. Schattenberg   +7 more
doaj   +1 more source

Expression of Molecular Differentiation Markers Does Not Correlate with Histological Differentiation Grade in Intrahepatic Cholangiocarcinoma. [PDF]

PLoS ONE, 2016
The differentiation status of tumor cells, defined by histomorphological criteria, is a prognostic factor for survival of patients affected with intrahepatic cholangiocarcinoma (ICC).
Céline Demarez, Catherine Hubert, Christine Sempoux, Frédéric P Lemaigre   +3 more
doaj   +1 more source