Results 111 to 120 of about 993,672 (387)

Development and characterization of a new human hepatic cell line [PDF]

, 2015
The increasing demand and hampered use of primary human hepatocytes for research purposes have urged scientists to search for alternative cell sources, such as immortalized hepatic cell lines.
Berx, Geert, De Craene, Bram, De Kock, Joey, Ramboer, Eva, Rogiers, Vera, Vanhaecke, Tamara, Vinken, Mathieu   +6 more
core   +4 more sources

Core promoter: A critical region where the hepatitis B virus makes decisions [PDF]

, 2014
The core promoter (CP) of the viral genome plays an important role for hepatitis B virus (HBV) replication as it directs initiation of transcription for the synthesis of both the precore and pregenomic (pg) RNAs.
Quarleri, Jorge Fabian
core   +1 more source

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

Transcriptional regulation of the human hepatic lipase (LIPC) gene promoter

Journal of Lipid Research, 2006
Hepatic lipase (HL) plays a key role in the metabolism of plasma lipoproteins, and its level of activity requires tight regulation, given the association of both low and high levels with atherosclerosis and coronary artery disease.
Laura E. Rufibach, Stephen A. Duncan, Michele Battle, Samir S. Deeb   +3 more
doaj  

Impaired RelA signaling and lipid metabolism dysregulation in hepatocytes: driving forces in the progression of metabolic dysfunction-associated steatotic liver disease

Cell Death Discovery
RelA, also known as nuclear factor kappa B p65, plays a crucial role in the pathogenesis of various liver diseases. However, the specific role of RelA in hepatocytes during the progression of metabolic dysfunction-associated steatotic liver disease ...
Yihuai He, Jinlian Jiang, Lili Ou, Yunfen Chen, Aikedaimu Abudukeremu, Guimei Chen, Weiwei Zhong, Zhigang Jiang, Nuerbiye Nuermaimaiti, Yaqun Guan   +9 more
doaj   +1 more source

Gentiopicroside ameliorates CCl-induced liver injury in mice by regulating the PPAR-γ/Nrf2 and NF-κB/IκB signaling pathways

Journal of International Medical Research, 2023
Objective This study explored the mechanisms by which gentiopicroside protects against carbon tetrachloride (CCl 4 )-induced liver injury. Methods Male mice were randomly assigned to the control; CCl 4 ; bifendate 100 mg/kg; or gentiopicroside 25, 50, or
Yun Zhang, Shiguang Pan, Shiming Yi, Jin Sun, Haitao Wang   +4 more
doaj   +1 more source

Re-cycling of DNA-containing Capsids Enhances Hepatitis B Virus Infection [PDF]

arXiv, 2023
Hepatitis B virus infection is a deadly liver disease. A part of newly produced HBV DNA-containing capsids are reused as a core particle in HBV replication. It is investigated that the recycling of HBV capsids greatly affects the intracellular dynamics of HBV infection.
arxiv  

Isomers of the TCF1 gene encoding hepatocyte nuclear factor-1 alpha show differential expression in the pancreas and define the relationship between mutation position and clinical phenotype in monogenic diabetes.

Human Molecular Genetics, 2006
The generation of multiple transcripts by mRNA processing has the potential to moderate differences in gene expression both between tissues and at different stages of development.
L. Harries, S. Ellard, A. Stride, N. Morgan, A. Hattersley   +4 more
semanticscholar   +1 more source

Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARα [PDF]

, 2016
Adaptation to fasting involves both Glucocorticoid Receptor (GRα) and Peroxisome Proliferator-Activated Receptor α (PPARα) activation. Given both receptors can physically interact we investigated the possibility of a genome-wide cross-talk between ...
Bougarne, Nadia, Caron, Sandrine, De Bosscher, Karolien, De Cauwer, Lode, Hennuyer, Nathalie, Libert, Claude, Lievens, Sam, Mylka, Viacheslav, Paumelle, Réjane, Pawlak, Michal, Ratman, Dariusz, Rider, Mark H, Staels, Bart, Tavernier, Jan, Thommis, Jonathan   +14 more
core   +3 more sources

Activation of SIRT1 Reduces Renal Tubular Epithelial Cells Fibrosis in Hypoxia Through SIRT1‐FoxO1‐FoxO3‐Autophagy Pathway

Advanced Biology, EarlyView.
Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang, Lijuan Zhang, Jiaorong Tan, Fei Li, Yishan Jin, Limei He, Xin Yang   +6 more
wiley   +1 more source