Results 111 to 120 of about 136,980 (341)

Microphysiological Systems of Lymphatics and Immune Organs

Advanced Healthcare Materials, EarlyView.
This review surveys recent progress in engineering lymphatic microenvironments and immune organoids within microphysiological systems, emphasizing innovative strategies to recreate the biochemical and biophysical complexity of native lymphatic tissues.
Ishita Jain, Ankur Singh, Andrés J. García   +2 more
wiley   +1 more source

TLRs, NF-κB, JNK, and Liver Regeneration

Gastroenterology Research and Practice, 2010
While hepatocytes rarely undergo proliferation in normal livers, they quickly induce proliferation in response to loss of liver mass by toxin or inflammation-induced hepatocyte injury, trauma, or surgical resection, leading to a restoration of liver mass
Yuji Iimuro, Jiro Fujimoto
doaj   +1 more source

Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease [PDF]

, 2016
Previous studies showed that YAP1 is over-expressed in hepatocellular carcinoma (HCC). Here we observed higher expression of Yap1/Ctgf axis in dysplastic nodules and HCC chemically-induced in F344 rats, genetically susceptible to hepatocarcinogenesis ...
Avila, Matias A., Berasain, Carmen, Brozzetti, Stefania, Calvisi, Diego F., Daino, Lucia, Demartis, Maria I., Feo, Claudio F., Feo, Francesco, Latte, Gavinella, Pascale, Rosa M., Porcu, Alberto, Seddaiu, Maria A., Simile, Maria M., Tomasi, Maria L.   +13 more
core   +2 more sources

Hepatocyte nuclear factor-1  gene deletions--a common cause of renal disease [PDF]

Nephrology Dialysis Transplantation, 2007
Hepatocyte nuclear factor-1beta (HNF-1beta) is a critical transcription factor in pancreatic and renal development. Our previous report identified HNF-1beta mutations in 23/160 patients with unexplained renal disease. The most common phenotype is renal cysts, which is frequently associated with early-onset diabetes in the renal cysts and diabetes (RCAD)
Emma L, Edghill, Richard A, Oram, Martina, Owens, Karen L, Stals, Lorna W, Harries, Andrew T, Hattersley, Sian, Ellard, Coralie, Bingham   +7 more
openaire   +2 more sources

Automating Vascular Biology: An End‐to‐End Automated Workflow for High‐Throughput Blood Vessel‐on‐a‐Chip Production and Multi‐Site Validation

Advanced Healthcare Materials, EarlyView.
AngioPlate384 is a 384‐well open‐top platform that automates production of more than 100 miniaturized, perfusable blood vessels embedded in hydrogel and supported by stromal cells. Stromal‐endothelial co‐culture strengthens blood vessel barrier function and yields responses useful for translational planning. Scalable and automation‐ready, it suits drug
Dawn S. Y. Lin, Hanieh Mohammad Hashemi, Kimia Asadi Jozani, Anushree Chakravarty, Sonya Kouthouridis, Jessica Bonanno, Nicky Anvari, Shravanthi Rajasekar, Feng Zhang, Richard Y. Cheng, Narendra Kumar Singh, Luis Miguel Medina, Marc Durante, Yufang He, Boyang Zhang   +14 more
wiley   +1 more source

Estudio clínico y mutacional de una cohorte de pacientes con mutación en el gen hnf1b [PDF]

, 2013
HNF1B (Hepatocyte Nuclear Factor 1-B localizado en el cromosoma 17q21.3) es un factor de transcripción con un papel fundamental en los primeros estadios del desarrollo y en la organogénesis de diferentes tejidos como el renal, hepático, pancreático o ...
Ayasreh Fierro, Nadia, Universitat Autònoma de Barcelona. Departament de Medicina, Universitat Autònoma de Barcelona. Facultat de Medicina   +2 more
core   +1 more source

The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition [PDF]

, 2016
The transcription factor Snail is a master regulator of cellular identity and epithelial-to-mesenchymal transition (EMT) directly repressing a broad repertoire of epithelial genes.
A Kuzmichev, A Tramontano, AM Khalil, C Battistelli, C Battistelli, C Chu, C Cicchini, C Cicchini, C Cicchini, C Cicchini, C Cicchini, C Cifuentes-Rojas, C Davidovich, CA McHugh, CL Tien, E Bolotin, F Garibaldi, F J Gonzalez, G Deb, G Grassi, H Peinado, H Peinado, J Chen, J Yang, J Zhao, JA Simon, JL Rinn, JP Thiery, KD Nolan, L Amicone, L Amicone, L Grassi, L Li, L Santangelo, L Santangelo, M Colletti, M Courel, M Kretz, M Rodriguez, M Tripodi, M Yu, MA Nieto, MA Perez-Moreno, MC Tsai, OG McDonald, P Arnold, P Wongtrakoongate, Q Cao, R Cao, R Kogo, RA Gupta, RY Huang, S Fujii, S Javaid, S Kaneko, S Lamouille, TD Schmittgen, V de Nonno, Y Chen, Y Lin, Y Nie, Y Yonemitsu, YJ Geng, Z Hou, Z Yang, ZT Tong   +65 more
core   +2 more sources

Construction of a Multitissue Cell Atlas Reveals Cell‐Type‐Specific Regulation of Molecular and Complex Phenotypes in Pigs

Advanced Science, EarlyView.
This research conducts an in‐depth investigation of cell‐type‐specific regulatory mechanisms underlying molecular and complex phenotypes through integrative analysis of multitissue single‐nucleus RNA sequencing, bulk RNA‐seq, and genome‐wide association study (GWAS) data in pigs.
Lijuan Chen, Houcheng Li, Jinyan Teng, Zhen Wang, Xiaolu Qu, Zhe Chen, Xiaodian Cai, Haonan Zeng, Zhonghao Bai, Jinghui Li, Xiangchun Pan, Leyan Yan, Fei Wang, Lin Lin, Yonglun Luo, Goutam Sahana, Mogens Sandø Lund, Maria Ballester, Daniel Crespo‐Piazuelo, Peter Karlskov‐Mortensen, Merete Fredholm, Alex Clop, Marcel Amills, Crystal Loving, Christopher K. Tuggle, Ole Madsen, Jiaqi Li, Zhe Zhang, George E. Liu, Jicai Jiang, Lingzhao Fang, Guoqiang Yi   +31 more
wiley   +1 more source

Clinical and molecular characterization of maturity onset-diabetes of the young caused by hepatocyte nuclear factor-4 alpha mutation: red flags for prediction of the diagnosis

Annals of Saudi Medicine, 2014
BACKGROUND AND OBJECTIVES: The prevalence of maturity-onset diabetes of the young (MODY) in Saudi population remains unknown, and data on molecular etiology of this condition is limited.
Sarar Mohamed, Susan Elkholy, Ebtessam El-Meleagy, Khaled Abu-Amero, Ali M. Hellani   +4 more
doaj   +1 more source

Deficiency of the purinergic receptor 2X7 attenuates nonalcoholic steatohepatitis induced by high-fat diet. possible role of the NLRP3 Inflammasome [PDF]

, 2017
Molecular mechanisms driving transition from simple steatosis to nonalcoholic steatohepatitis (NASH), a critical step in the progression of nonalcoholic fatty liver disease (NAFLD) to cirrhosis, are poorly defined. This study aimed at investigating the
Blasetti Fantauzzi, Claudia, Iacobini, Carla, Menini, Stefano, Pugliese, Giuseppe, Rossi, Chiara, Santini, Eleonora, Solini, Anna   +6 more
core   +3 more sources