Results 261 to 270 of about 993,672 (387)

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Bone Morphogenetic Protein 3 Controls Insulin Gene Expression and Is Down-regulated in INS-1 Cells Inducibly Expressing a Hepatocyte Nuclear Factor 1A–Maturity-onset Diabetes of the Young Mutation [PDF]

, 2011
Caroline Bonner, Angela M. Farrelly, Caoimhín G. Concannon, Heiko Düßmann, Mathurin Baquié, Isabelle Virard, H Wobser, Donat Kögel, Claes B. Wollheim, Marjan Slak Rupnik, M. M. Byrne, Hans‐Georg König, Jochen H.M. Prehn   +12 more
openalex   +1 more source

Saikosaponin b1 Attenuates Liver Fibrosis by Blocking STAT3/Gli1 Interaction and Inducing Gli1 Degradation

Exploration, EarlyView.
Saikosaponin b1 attenuates liver fibrosis by competitively disrupting the interaction between signal transducer and activator of transcription 3 (STAT3) and glioma‐associated oncogene‐1 (Gli1) in the activated hepatic stellate cells (HSCs). The blocked interaction of STAT3 and Gli1 promotes the degradation of Gli1, inhibits Gli1 transcriptional ...
Meiyu Shao, Xiaoqing Zhang, Jiamei Sun, Hongyan Dong, Xin Han, Qiao Yang, Roufen Chen, Liteng Shen, Lei Xu, Lu Wang, Bo Zhu, Dongxin Tang, Shuosheng Zhang, Keda Lu, Mengyun Peng, Gang Cao   +15 more
wiley   +1 more source

Diurnal Regulation of the Early Growth Response 1 (Egr-1) Protein Expression by Hepatocyte Nuclear Factor 4α (HNF4α) and Small Heterodimer Partner (SHP) Cross-talk in Liver Fibrosis [PDF]

, 2011
Yuxia Zhang, Jessica A. Bonzo, Frank J. Gonzalez, Li Wang   +3 more
openalex   +1 more source

Hepatocellular Adenoma With Hepatocyte Nuclear Factor-1 Alpha (HNF-1α) Mutation: A Case Report. [PDF]

Cureus
Moliya P, Al-Obaidi H, Harb H, Moliya U, Asit M.   +4 more
europepmc   +1 more source

Exploring the bio‐functional potential of polysaccharides from Morchella esculenta: A mini review

Food Biomacromolecules, EarlyView.
Abstract Polysaccharides, natural polymers of monosaccharides, exhibit diverse biological activities due to their molecular structures and functional properties. Morchella esculenta, a precious edible mushroom with higher market value, is also rich in polysaccharides (MEP) and holds potential as a bioactive compound with therapeutic and functional food
Shiva Bakshi, Vinod Kumar Paswan
wiley   +1 more source

Hepatocyte Nuclear Factor 1 Regulates the Expression of the Organic Cation Transporter 1 via Binding to an Evolutionary Conserved Region in Intron 1 of the OCT1 Gene

Journal of Pharmacology and Experimental Therapeutics, 2013
V. O'Brien, K. Bokelmann, J. Ramírez, K. Jobst, M. Ratain, J. Brockmöller, M. Tzvetkov   +6 more
semanticscholar   +1 more source

Studies on the Effect of Piperine on Hepatocyte Nuclear Factor 1 Alpha (HNF-1α) and Sterol Regulatory Element-Binding Protein 1c (SREBP-1c) Levels in High-Fat-Diet and Sucrose-Induced Type 2 Diabetes Mellitus Rats. [PDF]

Cureus
Zuvairiya U, Jayaraman S, Sankaran K, Veeraraghavan VP, R G.   +4 more
europepmc   +1 more source

Isolation and Extraction of Gentian Polysaccharide and Its Protective Effect on Chemical Liver Injury

Food Safety and Health, EarlyView.
The water‐soluble polysaccharide GSBP‐N‐a‐1 with an average molecular weight of 3.82 kDa was successfully isolated and purified from Gentiana scabra. It was confirmed that the crude polysaccharides of Gentiana scabra could inhibit oxidative stress and inflammatory response by activating the Nrf2‐HO‐1 pathway, and significantly alleviate the chemical ...
Tianjiao Fu, Yan Dong, Guangxin Yuan
wiley   +1 more source

Protein arginine methyl transferase 1– and Jumonji C domain‐containing protein 6–dependent arginine methylation regulate hepatocyte nuclear factor 4 alpha expression and hepatocyte proliferation in mice [PDF]

, 2017
Jie Zhao, Abby Adams, Ben Roberts, Maura O’Neil, Anusha Vittal, Timothy M. Schmitt, Sean C. Kumer, Josiah Cox, Zhuan Li, Steven A. Weinman, Irina Tikhanovich   +10 more
openalex   +1 more source