Results 301 to 310 of about 136,980 (341)

The Interplay Between Cellular Senescence and Lipid Metabolism in the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). [PDF]

Int J Mol Sci
Mastoridou EM, Goussia AC, Kataki A, Koniaris E, Glantzounis GK, Papoudou-Bai A, Kanavaros P, Charchanti AV.   +7 more
europepmc   +1 more source

Targeting Ras homolog enriched in brain 1 to restore β-cell mass and function: A potential therapeutic strategy for diabetes. [PDF]

World J Diabetes
Peng Y, Zhang DD, Gan L, Zhang JQ.
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Hepatocyte nuclear factor 1 negatively regulates amylin gene expression

Biochemical and Biophysical Research Communications, 2003
Maturity-onset diabetes of the young (MODY) is a monogenic subtype of Type 2 diabetes, defined as having an early age of onset, with a dominant inheritance pattern. Hepatocyte nuclear factor 1 (HNF1), which is encoded by the MODY3 gene, has been shown to bind the insulin promoter. Since the promoters of three pancreas-specific genes involved in glucose
Green, Janelle, Naot, Dorit, Cooper, Garth   +2 more
openaire   +3 more sources

Expression ratio of hepatocyte nuclear factor-1 to variant hepatocyte nuclear factor-1 in differentiation of hepatocellular carcinoma and hepatoblastoma

Journal of Hepatology, 1996
Liver-specific protein genes have multiple cis-/trans-acting elements, but those accountable for hepatocytic differentiation are unclear. An AT-rich core sequence (AT motif) is essential as a cis-acting element for the hepatic transcription. Homologous proteins hepatocyte nuclear factor-1 (HNF-1) and variant HNF-1 (vHNF-1) bind to this motif. The ratio
T, Ninomiya, Y, Hayashi, K, Saijoh, K, Ohta, S, Yoon, H, Nakabayashi, T, Tamaoki, M, Kasuga, H, Itoh   +8 more
openaire   +2 more sources

Modulation of Hepatic Gene Expression by Hepatocyte Nuclear Factor 1

Science, 1997
Hepatocyte nuclear factors 1 and 4 (HNF-1 and HNF-4) are liver-enriched transcription factors that function in the regulation of several liver-specific genes. HNF-1 activates genes containing promoters with HNF-1 binding sites. However, this factor negatively regulates its own expression and that of other HNF-4–dependent genes that lack HNF-1 binding ...
E, Ktistaki, I, Talianidis
openaire   +2 more sources

Injury induces rapid changes in hepatocyte nuclear factor-1: DNA binding

Surgery, 1996
Transcriptional regulation in the liver plays a critical role in mediating the acute phase response to injury. The molecular mechanisms driving these transcriptional events, however, are poorly defined in vivo. The liver-specific transcription factor hepatocyte nuclear factor (HNF)-1 binds to the 5' upstream region of many acute phase genes. To explore
P A, Burke, M, Luo, J, Zhu, M B, Yaffe, R A, Forse   +4 more
openaire   +2 more sources

Variant Hepatocyte Nuclear Factor 1 is required for visceral endoderm specification

Development, 1999
Abstract Genetic and molecular evidence indicates that visceral endoderm, an extraembryonic cell lineage, is required for gastrulation, early anterior neural patterning, cell death and specification of posterior mesodermal cell fates. We show that variant Hepatocyte Nuclear Factor 1 (vHNF1), a homeodomain-containing transcription factor ...
E, Barbacci, M, Reber, M O, Ott, C, Breillat, F, Huetz, S, Cereghini   +5 more
openaire   +2 more sources

Hepatocyte nuclear factor 1 beta induces transformation and epithelial‐to‐mesenchymal transition

FEBS Letters, 2016
Gene amplification can be a cause of cancer, and driver oncogenes have been often identified in amplified regions. However, comprehensive analysis of other genes coamplified with an oncogene is rarely performed. We focused on the 17q12–21 amplicon, which contains ERBB2.
Atsuka, Matsui, Jiro, Fujimoto, Kosuke, Ishikawa, Emi, Ito, Naoki, Goshima, Shinya, Watanabe, Kentaro, Semba   +6 more
openaire   +2 more sources