Results 301 to 310 of about 868,517 (361)

Research progress on AMPK in the pathogenesis and treatment of MASLD. [PDF]

Front Immunol
Feng J, MengHuan L, TingTing Y, XueJie Y, HaiNing G.   +4 more
europepmc   +1 more source

Clustering of Membrane Receptors: Insights from DNA Origami‐Based Approaches

Small, EarlyView.
Receptor clustering critically influences cell signaling, yet its precise regulation remains elusive. This review highlights how DNA origami structures serve as nanoscale tools to uncover receptor organization and provide new insights into signal transduction.
Carmen M. Domínguez, Christof M. Niemeyer   +1 more
wiley   +1 more source

SIRT7-mediated NRF2 deacetylation promotes antioxidant response and protects against chemodrug-induced liver injury. [PDF]

Cell Death Dis
Yu T, Ding C, Peng J, Liang G, Tang Y, Zhao J, Li Z.   +6 more
europepmc   +1 more source

Hepatocyte ALOXE3 is induced during adaptive fasting and enhances insulin sensitivity by activating hepatic PPARγ [PDF]

, 2018
DeBosch, Brian J, Fujiwara, Hideji, Graham, Mark J, Higgins, Cassandra B, Mayer, Allyson L, Stothard, Alicyn I, Swarts, Benjamin M, Zhang, Yiming   +7 more
core   +1 more source

Acute kidney injury and iron metabolism: A narrative review focusing on pathophysiology and therapy

Smart Molecules, EarlyView.
Schematic illustration of acute kidney injury and iron metabolism (By Figdraw). Image for iron metabolism, including uptake, storage, utilization, export: Reproduced with permission. Abstract Acute kidney injury (AKI) represents a substantial challenge to public health and is characterized by elevated occurrence and fatality rates.
Xinyu Tan, Man Li, Jing Chen, Gang Liu, Zhixiang Lu   +4 more
wiley   +1 more source

Constitutive androstane receptor, liver pathophysiology and chemical contaminants: current evidence and perspectives. [PDF]

Front Endocrinol (Lausanne)
De Battistis F, Djordjevic AB, Saso L, Mantovani A.   +3 more
europepmc   +1 more source

Complex‐mediated nucleophilic aromatic substitution with aryl nitriles to realize intramolecular flapping‐restricted D‐A AIEgens for bioimaging

Smart Molecules, EarlyView.
In this work, we developed a complex‐mediated nucleophilic aromatic substitution which can generate rich D‐A AIEgens under a facile condition. The AIE mechanism of such AIEgens was unveiled and their application towards fatty liver imaging was exhibited. Abstract Donor‐acceptor (D‐A) compounds are particularly important in optoelectronic and biological
Feng Liu, Junkai Liu, Junyi Gong, Runfeng Lin, Siyuan Qiu, Zicheng Liu, Chongyang Li, Miao Meng, Shijie Li, Mei Tu, Jacky W. Y. Lam, Guangle Niu, Ming Chen   +12 more
wiley   +1 more source

The Active Components of Traditional Chinese Medicines Regulate the Multi-Target Signaling Pathways of Metabolic Dysfunction-Associated Fatty Liver Disease. [PDF]

Drug Des Devel Ther
Song Z, Bu S, Sang S, Li J, Zhang X, Song X, Ran Y.   +6 more
europepmc   +1 more source

The effects of FK 506, cyclosporine, and rapamycin on liver growth in vitro and in vivo [PDF]

, 1991
Azzarone, A, Carr, B, Carrieri, G, Francavilla, A, Porter, KA, Starzl, TE, Zeng, QH   +6 more
core  

Systemic Brain Delivery of Oligonucleotide Therapeutics Enhanced by Protein Corona‐Assisted DNA Cubes

Small Methods, EarlyView.
In vivo, screening of DNA nanostructures yields a cube‐shaped structure (D‐Cb) as a protein corona‐assisted platform for brain delivery of oligonucleotide therapeutics. D‐Cb effectively delivers polo‐like kinase 1 (PLK‐1) antisense oligonucleotides (ASO) to treat glioblastoma in an orthotopic mouse model, demonstrating its potential as a carrier for ...
Kyoung‐Ran Kim, Ji Hee Kang, Hien Bao Dieu Thai, Ji Hyun Back, Chengde Mao, Ji Eun Lee, Young Tag Ko, Dae‐Ro Ahn   +7 more
wiley   +1 more source