Results 81 to 90 of about 86,113 (258)

Hepatocyte Nuclear Factor 1 Binds to and Transactivates the Human but Not the Rat CYP7A1 Promoter

Biochemical and Biophysical Research Communications, 1999
Cholesterol 7alpha-hydroxylase (CYP7A1), a liver-specific enzyme, catalyzes the rate-limiting step in the degradation pathway of cholesterol to bile acids, and thus plays a key role in cholesterol homeostasis. To elucidate the mechanisms that control hepatic expression of the human CYP7A1 gene, we are studying the promoter region.
J, Chen, A D, Cooper, B, Levy-Wilson
openaire   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

FGL2‐HDAC11 Drives Immunothrombosis via NETs‐Mediated Endothelial Capillarization in MASLD Fibrosis

Advanced Science, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is frequently accompanied by hepatic fibrosis and systemic cardiovascular complications; however, the mechanistic interplay between coagulation abnormalities and disease progression remains poorly defined.
Xitang Li, Junjian Hu, Suping Hai, Peng Hu, Wenhui Wu, Qiang Gao, Binghui Yu, Feiyang Xu, Xizhe Zheng, Qianting Guan, Huiling Xiang, Dong Xi, Weiming Yan, Peng Wang, Bin‐hao Zhang, Qin Ning, Xiaojing Wang   +16 more
wiley   +1 more source

Ischemic preconditioning promotes hepatic differentiation in human liver organoids

Frontiers in Cell and Developmental Biology
IntroductionLiver regeneration is essential for successful outcomes after liver transplantation. However, ischemia-reperfusion injury (IRI) remains a major determinant of graft dysfunction that can profoundly affect hepatic regenerative responses ...
Maura Cimino, Rosaria Tinnirello, Andrea Orlando, Andrea Orlando, Simone Messina, Salvatore Gruttadauria, Salvatore Gruttadauria, Salvatore Gruttadauria, Duilio Pagano, Duilio Pagano, Pier Giulio Conaldi, Alessandro Mattina, Alessandro Mattina, Riccardo Perriera, Giovanni Zito, Massimo Pinzani, Vitale Miceli   +16 more
doaj   +1 more source

TLRs, NF-κB, JNK, and Liver Regeneration

Gastroenterology Research and Practice, 2010
While hepatocytes rarely undergo proliferation in normal livers, they quickly induce proliferation in response to loss of liver mass by toxin or inflammation-induced hepatocyte injury, trauma, or surgical resection, leading to a restoration of liver mass
Yuji Iimuro, Jiro Fujimoto
doaj   +1 more source

Gut Microbiota, Immunity, and Metabolism in the Progression From Chronic Liver Disease to Hepatocellular Carcinoma

Advanced Science, EarlyView.
This review explains how chronic liver injury progresses toward hepatocellular carcinoma through interconnected changes in gut microbes, metabolism, immunity, fibrosis, and diet. It highlights microbial metabolites, bile‐acid signaling, immune dysfunction, and nutritional or microbiome‐based interventions as opportunities to identify risk earlier ...
Yi Hu, Caiyan Lin, Lijie Zhang, Xue Jiang, Huawen Li, Yangzhe Wu   +5 more
wiley   +1 more source

Clinical and molecular characterization of maturity onset-diabetes of the young caused by hepatocyte nuclear factor-4 alpha mutation: red flags for prediction of the diagnosis

Annals of Saudi Medicine, 2014
BACKGROUND AND OBJECTIVES: The prevalence of maturity-onset diabetes of the young (MODY) in Saudi population remains unknown, and data on molecular etiology of this condition is limited.
Sarar Mohamed, Susan Elkholy, Ebtessam El-Meleagy, Khaled Abu-Amero, Ali M. Hellani   +4 more
doaj   +1 more source

Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing

Advanced Science, EarlyView.
An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, Otto Kollmar, Mairene Coto‐Llerena, Luca Di Tommaso, Visar Vela, Lukas Bubendorf, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio   +17 more
wiley   +1 more source

The hepatocyte nuclear factor 1 homeobox A (HNF1A) gene polymorphism and AFP serum levels in Egyptian HCC patients

Egyptian Liver Journal
Background Hepatocyte nuclear factors were first identified as liver-enriched transcription factors that might participate in various activities related to the transcription of genes unique to the liver.
Hanan M. Bedair, Ibrahim El-Tantawy El Sayed, Olfat M. Hendy, Mohmed Abdel-Samiee, Islam Abd El Hamid El Sayad, Sally S. Mandour   +5 more
doaj   +1 more source

Metabolomic analysis of the Hepatocyte Nuclear Factor 1 Alpha knockout mouse

The FASEB Journal, 2010
Genomic mutations in the transcription factor hepatocyte nuclear factor 1 alpha ( HNF1α ) result in maturity‐onset diabetes of the young type 3 (MODY3), a form of non‐insulin dependent diabetes mellitus (NIDDM). In addition, Hnf1α was identified
Jessica A Bonzo, Andrew D Patterson, Kristopher W Krausz, Frank J Gonzalez   +3 more
openaire   +1 more source