Results 71 to 80 of about 86,113 (258)

Homeostatic regulation of hepatocyte nuclear transcription factor 1 expression in cultured hepatoma cells. [PDF]

Proceedings of the National Academy of Sciences, 1994
Serum colloid osmotic pressure is believed to control the hepatic output of plasma proteins, including albumin. The present study was aimed at identifying the molecular basis for feedback control of albumin gene expression in highly differentiated hepatoma cells.
PIETRANGELO, Antonello, D. A. SHAFRITZ
openaire   +2 more sources

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Improved Progression-Free Survival in Irinotecan-Treated Metastatic Colorectal Cancer Patients Carrying the HNF1A Coding Variant p.I27L

Frontiers in Pharmacology, 2017
Hepatocyte nuclear factor 1-alpha (HNF1A) is a liver-enriched transcription factor that plays a key role in many aspects of hepatic functions including detoxification processes.
Adrien Labriet, Adrien Labriet, Elena De Mattia, Erika Cecchin, Éric Lévesque, Éric Lévesque, Derek Jonker, Félix Couture, Félix Couture, Angela Buonadonna, Mario D’Andrea, Lyne Villeneuve, Lyne Villeneuve, Giuseppe Toffoli, Chantal Guillemette, Chantal Guillemette   +15 more
doaj   +1 more source

TRIB1 regulates liver regeneration by antagonizing the NRF2-mediated antioxidant response

Cell Death and Disease, 2023
Robust regenerative response post liver injuries facilitates the architectural and functional recovery of the liver. Intrahepatic redox homeostasis plays a key role in liver regeneration.
Xinyue Sun, Shuai Wang, Xiulian Miao, Sheng Zeng, Yan Guo, Anqi Zhou, Ying Chen, Yifei Chen, Fangqiao Lv, Zhiwen Fan, Yutong Wang, Yong Xu, Zilong Li   +12 more
doaj   +1 more source

Abnormal splicing of hepatocyte nuclear factor-1 beta in the renal cysts and diabetes syndrome [PDF]

Diabetologia, 2004
Mutations in the hepatocyte nuclear factor-1 beta ( HNF-1 beta) gene result in disorders of renal development, typically involving renal cysts and early-onset diabetes (the RCAD syndrome/ MODY5). Sixteen mutations have been reported, including three splicing mutations of the intron 2 splice donor site.
L W, Harries, S, Ellard, R W A, Jones, A T, Hattersley, C, Bingham   +4 more
openaire   +2 more sources

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

PGC-1α protects against MASH via Tim23-dependent inhibition of DRP1-mediated ferroptosis

Cell Death and Disease
Peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) is crucial for mitochondrial function and biogenesis. However, whether and how PGC-1α can regulate hepatocyte ferroptosis during the pathogenic process of metabolic dysfunction ...
Yanmian Zhao, Linzhong Zhang, Bairong Li, Menghan Liu, Yanting Zhang, Teng Li, Shoubin Ning, Xiuying Zhang   +7 more
doaj   +1 more source

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2[S]

Journal of Lipid Research, 2014
Acat2 [gene name: sterol O-acyltransferase 2 (SOAT2)] esterifies cholesterol in enterocytes and hepatocytes. This study aims to identify repressor elements in the human SOAT2 promoter and evaluate their in vivo relevance.
Camilla Pramfalk, Tiffany A. Melhuish, David Wotton, Zhao-Yan Jiang, Mats Eriksson, Paolo Parini   +5 more
doaj   +1 more source

Self‐Organizing Human Induced Pluripotent Stem Cell Hepatocyte 3D Organoids Inform the Biology of the Pleiotropic TRIB1 Gene

Hepatology Communications, 2020
Establishment of a physiologically relevant human hepatocyte‐like cell system for in vitro translational research has been hampered by the limited availability of cell models that accurately reflect human biology and the pathophysiology of human disease.
Deepti Abbey, Susannah Elwyn, Nicholas J. Hand, Kiran Musunuru, Daniel J. Rader   +4 more
doaj   +1 more source