Results 51 to 60 of about 86,113 (258)

Regulation of apoA-I gene expression

Journal of Lipid Research, 2004
We have previously shown that 17-β-estradiol (E2) and genistein increase the expression of apolipoprotein A-I (apoA-I), the major protein component of HDL, in Hep G2 cells.
Stefania Lamon-Fava, Dale Micherone
doaj   +1 more source

Mutation of TCF1 encoding hepatocyte nuclear factor 1α in gynecological cancer [PDF]

Oncogene, 2004
TCF1: (transcription factor 1) encoding hepatocyte nuclear factor 1alpha (HNF1alpha) is mutated in 50% of liver cell adenomas, a benign tumor closely associated with oral contraceptive use. These genetic alterations inactivate both alleles, leading to the absence of wild-type HNF1alpha expression in liver cell adenomas.
Rebouissou, Sandra, Rosty, Christophe, Lecuru, Fabrice, Boisselier, Sophie, Bui, Hung, Le Frere-Belfa, Marie-Aude, Sastre, Xavier, Laurent-Puig, Pierre, Zucman-Rossi, Jessica   +8 more
openaire   +5 more sources

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

HCF-1 as a key modulator of OGT function and O-GlcNAcylation in the liver

Scientific Reports
Host cell factor-1 (HCF-1) is a transcriptional coregulator essential for maintaining liver function and cellular metabolism. O-linked N-acetylglucosamine transferase (OGT) is a key nutrient-sensing enzyme that catalyzes protein O-GlcNAcylation, a ...
Vaibhav Kapuria, Ayushma, Winship Herr, Shilpi Minocha   +3 more
doaj   +1 more source

Polychlorinated biphenyls-153 induces metabolic dysfunction through activation of ROS/NF-κB signaling via downregulation of HNF1b

Redox Biology, 2017
Polychlorinated biphenyls (PCB) is a major type of persistent organic pollutants (POPs) that act as endocrine-disrupting chemicals. In the current study, we examined the mechanism underlying the effect of PCB-153 on glucose and lipid metabolism in vivo ...
Hao Wu, Weihua Yu, Fansen Meng, Jie Mi, Jie Peng, Jiangzheng Liu, Xiaodi Zhang, Chunxu Hai, Xin Wang   +8 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

False-positive 18F fluorodeoxyglucose positron emission tomography-avid benign hepatic tumor: Previously unreported in a male patient

Indian Journal of Radiology and Imaging, 2018
We report a case of 18F fluorodeoxyglucose (FDG) positron emission tomography (PET)–computed tomography-avid histologically confirmed inflammatory hepatic adenoma in a 77-year-old male patient without any history of steroid, alcohol use.
Binit Sureka, Archana Rastogi, Amar Mukund, Shiv Kumar Sarin   +3 more
doaj   +1 more source

Human hepatocyte nuclear factor-1β (HNF1B) 1968A/G polymorphism [PDF]

Journal of Human Genetics, 2000
We found a novel A-->G change at nucleotide 1968 within the 3'-untranslated region of the HNF1B gene encoding the hepatocyte nuclear factor-1 beta. The HNF1B 1968A/G polymorphism could be detected by digestion with endonuclease MspI. The frequency of the HNF1B 1968G allele was 0.060 in Caucasians and 0.129 in Canadian Oji-Cree.
H, Cao, R A, Hegele
openaire   +2 more sources

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

Germline hepatocyte nuclear factor 1α and 1β mutations in renal cell carcinomas [PDF]

Human Molecular Genetics, 2005
Mutations in one copy of the hepatocyte nuclear factors (HNF) 1alpha and 1beta homeodomain containing transcription factors predispose the carrier to maturity-onset diabetes of the young (MODY) types 3 and 5, respectively. Moreover, previous identification of biallelic inactivation of HNF1alpha in hepatocellular adenoma identified its tumor suppressor ...
Rebouissou, Sandra, Vasiliu, Viorel, Thomas, Cristel, Bellanne-Chantelot, Christine, Bui, Hung, Chretien, Yves, Timsit, José, Rosty, Christophe, Laurent-Puig, Pierre, Chauveau, Dominique, Zucman-Rossi, Jessica   +10 more
openaire   +5 more sources