Results 31 to 40 of about 86,113 (258)

Association of HNF1A gene variants and haplotypes with metabolic syndrome: a case–control study in the Tunisian population and a meta-analysis

Diabetology & Metabolic Syndrome, 2022
Background Variants in the Hepatocyte Nuclear Factor 1 Alpha gene (HNF1A) are associated with lipoproteins levels and type 2 diabetes. In this study, we aimed to assess the association of HNF1A gene and haplotypes with the metabolic syndrome (MetS) and ...
Hamza Dallali, Meriem Hechmi, Imane Morjane, Sahar Elouej, Haifa Jmel, Yosra Ben Halima, Abdelmajid Abid, Afef Bahlous, Abdelhamid Barakat, Henda Jamoussi, Sonia Abdelhak, Rym Kefi   +11 more
doaj   +1 more source

Studies on the enzymatic and transcriptional activity of the dimerization cofactor for hepatocyte nuclear factor 1 [PDF]

Proceedings of the National Academy of Sciences, 1997
The relationship between the enzymatic and the transcriptional activity of the bifunctional protein pterin-4a-carbinolamine dehydratase/dimerization cofactor for hepatocyte nuclear factor 1 (DCoH) has been elucidated by site-directed mutagenesis.
G, Johnen, S, Kaufman
openaire   +2 more sources

Protective Effects of Costunolide Against D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice

Frontiers in Pharmacology, 2018
Costunolide, a sesquiterpene isolated from Vladimiria souliei (Franch.) Ling, is known to exhibit anti-inflammatory, anti-viral, and anti-tumor activities. However, the effects of costunolide on liver injury are poorly understood. The current study aimed
Jingxin Mao, Man Yi, Rui Wang, Yuanshe Huang, Min Chen   +4 more
doaj   +1 more source

Activation of p53 After Irradiation Impairs the Regenerative Capacity of the Mouse Liver

Hepatology Communications, 2022
Radiation therapy is one of the treatment methods for hepatocellular carcinoma. However, radiation tolerance of the liver is low, and the detailed effect of radiation on liver regeneration has not been clarified.
Makiko Urabe, Hayato Hikita, Yoshinobu Saito, Shinnosuke Kudo, Kenji Fukumoto, Naoki Mizutani, Yuta Myojin, Akira Doi, Katsuhiko Sato, Sadatsugu Sakane, Yuki Makino, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara   +14 more
doaj   +1 more source

MODY: Strategies for a unique form of diabetes

Journal of Education and Health Promotion
Maturity-onset diabetes of the young (MODY) is a monogenic, autosomal dominant form of diabetes that typically presents before the age of 25. It is caused by mutations in single genes involved in insulin production and glucose regulation, leading to ...
Ram K. Garg
doaj   +1 more source

The regulatory landscape of retinoblastoma: a pathway analysis perspective

Royal Society Open Science, 2022
Retinoblastoma (Rb) is a rare intraocular tumour in early childhood, with an approximate incidence of 1 in 18 000 live births. Experimental studies for Rb are complex due to the challenges associated with obtaining a normal retina to contrast with ...
Laura Gómez-Romero, Diana E. Alvarez-Suarez, Enrique Hernández-Lemus, M. Verónica Ponce-Castañeda, Hugo Tovar   +4 more
doaj   +1 more source

Repression of hepatocyte nuclear factor 4 alpha by AP-1 underlies dyslipidemia associated with retinoic acid[S]

Journal of Lipid Research, 2019
All-trans retinoic acid (atRA) is used to treat certain cancers and dermatologic diseases. A common adverse effect of atRA is hypercholesterolemia; cytochrome P450 (CYP) 7A repression is suggested as a driver. However, the underlying molecular mechanisms
Kyoung-Jae Won, Joo-Seop Park, Hyunyoung Jeong   +2 more
doaj   +1 more source

Malignant Transformation of an HNF1a-Inactivated Hepatocellular Adenoma to Hepatocellular Carcinoma

Case Reports in Gastroenterology, 2020
Hepatocellular adenomas (HCA) are rare benign tumors of the liver, occurring predominantly in females using oral contraceptives. Our case describes a 66-year-old woman presenting with a palpable mass in her upper abdomen.
Joris T. Hepkema, Floris B. Poelmann, Annette S.H. Gouw, Robbert J. de Haas, Evelien W. Duiker, Hans Blokzijl, Joost M. Klaase   +6 more
doaj   +1 more source

Structure of the gene enconding hepatocyte nuclear factor 1 (HNF1)

Nucleic Acids Research, 1992
Genomic clones have been isolated that cover the entire gene for the transcription factor HNF1 (hepatocyte nuclear factor 1). This protein governs the expression of many genes, synthesized in the liver in a tissue-specific manner. We have determined the intron/exon structure of the HNF1 gene, which is strictly conserved between rat and mouse and ...
I, Bach, M, Pontoglio, M, Yaniv
openaire   +3 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source