Results 11 to 20 of about 86,113 (258)
Liver receptor homolog-1 (NR5A2) orchestrates hepatic inflammation and TNF-induced cell death
Cell Reports, 2023 Summary: The nuclear receptor liver receptor homolog-1 (LRH-1) has been shown to promote apoptosis resistance in various tissues and disease contexts; however, its role in liver cell death remains unexplored.
Rebekka Lambrecht +9 more
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Tissue-specific expression of the gene encoding hepatocyte nuclear factor 1 may involve hepatocyte nuclear factor 4. [PDF]
Genes & Development, 1991 Hepatocyte nuclear factor 1 (HNF-1) is a transcriptional regulatory protein possibly involved in the activation of many liver-specifically expressed genes. HNF-1 mRNA is restricted to a small number of tissues, suggesting that the HNF-1 gene itself is regulated at the transcriptional level. We have isolated and characterized the promoter region of this
Tian, Jian-Min, Schibler, Ulrich
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Hepatocyte nuclear factor 1β controls nephron tubular development [PDF]
Development, 2013 Nephron morphogenesis is a complex process that generates blood-filtration units (glomeruli) connected to extremely long and patterned tubular structures. Hepatocyte nuclear factor 1β (HNF1β) is a divergent homeobox transcription factor that is expressed in kidney from the first steps of nephrogenesis.
Massa, F. +8 more
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Mutations in transcription factor as rare causes of diabetes in pregnancy
Сахарный диабет, 2019 MODY1 and MODY3 represent rare causes of diabetes in pregnancy. Establishing a molecular diagnosis of MODY1 or MODY3 during pregnancy may be important for minimizing risk of perinatal complications and for improving glycemic control after pregnancy.
Natalia A. Zubkova +8 more
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Stem Cell Research, 2021 Renal cysts and diabetes syndrome (RCAD) is caused by gene mutations in hepatocyte nuclear factor 1-β (HNF1B), but the underlying molecular mechanism is still unclear.
Shaoyuan Cui +7 more
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Purified hepatocyte nuclear factor 1 interacts with a family of hepatocyte-specific promoters. [PDF]
Proceedings of the National Academy of Sciences, 1988 During development cell types arise through the activation or repression of classes of specific genes. One hypothesis is that this phenomenon is realized by tissue-specific factors playing a role at the transcription level. Recently we have described a liver-specific nuclear protein, hepatocyte nuclear factor 1, that appears to be involved in the ...
G, Courtois +2 more
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A Novel HNF4A Mutation Causing Three Phenotypic Forms of Glucose Dysregulation in a Family
Frontiers in Pediatrics, 2020 Maturity-onset diabetes of the young (MODY) classically describes dominantly inherited forms of monogenic diabetes diagnosed before 25 years of age due to pancreatic β-cell dysfunction.
Suresh Chandran +13 more
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Regenerative Therapy, 2023 Objectives: The liver has an excellent ability to regenerate, and disrupted liver regeneration after various injuries leads to an unfavorable prognosis for patients.
Yalei Zhao +9 more
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Floridoside Exhibits Antioxidant Properties by Activating HO-1 Expression via p38/ERK MAPK Pathway
Marine Drugs, 2020 Floridoside is a low-molecular-weight organic compound, which can be accumulated by red algae under stressful conditions to protect cells via its excellent antioxidant properties.
Tingting Niu +6 more
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Animal, 2010 The significance of hepatocyte nuclear factors (HNFs) in β-cell development and function has been generally recognized in humans, as evidenced by their associations with cases of maturity onset diabetes of the young (MODY).
B. Fan, Z.-Q. Du, M.F. Rothschild
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