Results 1 to 10 of about 86,113 (258)

Hepatocyte nuclear factor 1 beta: A perspective in cancer [PDF]

Cancer Medicine, 2021
Hepatocyte nuclear factor 1 beta (HNF1 β/B) exists as a homeobox transcription factor having a vital role in the embryonic development of organs mainly liver, kidney and pancreas. Initially described as a gene causing maturity‐onset diabetes of the young
Shubhra Chandra, Srilakshmi Srinivasan, Jyotsna Batra   +2 more
doaj   +7 more sources

Hepatocyte Nuclear Factor 1 Beta Mutation-associated Newborn Onset of Glomerulocystic Kidney Disease: A Case Presentation [PDF]

Medeniyet Medical Journal, 2021
Mutations in hepatocyte nuclear factor-1 beta (HNF1B) are the most commonly identified genetic cause of renal malformations. Heterozygous mutations are associated with renal cysts and diabetes syndrome.
Nilüfer Göknar, Melda Ekici Avcı, Diana Üçkardeş, Emre Keleşoğlu, Kübra Tekkuş Ermiş, Cengiz Candan   +5 more
doaj   +2 more sources

Hepatocyte nuclear factor 1 alpha influences pancreatic cancer growth and metastasis. [PDF]

Sci Rep, 2020
AbstractHepatocyte nuclear factor 1 homeobox alpha (HNF1α) is a transcription factor involved in endodermal organogenesis and pancreatic precursor cell differentiation and development. Earlier studies have reported a role for HNF1α in pancreatic ductal adenocarcinoma (PDAC) but it is controversial.
Subramani R, Medel J, Flores K, Perry C, Galvez A, Sandoval M, Rivera S, Pedroza DA, Penner E, Chitti M, Lakshmanaswamy R.   +10 more
europepmc   +4 more sources

Transcriptional Regulation of the Angptl8 Gene by Hepatocyte Nuclear Factor-1 in the Murine Liver. [PDF]

Sci Rep, 2020
AbstractBrief refeeding times (~60 min) enhanced hepatic Angptl8 expression in fasted mice. We cloned the mouse Angptl8 promoter region to characterise this rapid refeeding-induced increase in hepatic Angptl8 expression. Deletion of the −309/−60 promoter region significantly attenuated basal promoter activity in hepatocytes.
Watanabe T, Ozawa A, Masuda S, Yoshino S, Ishida E, Kondo Y, Matsumoto S, Katano-Toki A, Horiguchi K, Nakajima Y, Yamada E, Tomaru T, Saito T, Ishii S, Shibusawa N, Okada S, Satoh T, Yamada M.   +17 more
europepmc   +4 more sources

Enhancement of CYP3A4 activity in Hep G2 cells by lentiviral transfection of hepatocyte nuclear factor-1 alpha. [PDF]

PLoS ONE, 2014
Human hepatoma cell lines are commonly used as alternatives to primary hepatocytes for the study of drug metabolism in vitro. However, the phase I cytochrome P450 (CYP) enzyme activities in these cell lines occur at a much lower level than their ...
Tsai-Shin Chiang, Kai-Chiang Yang, Ling-Ling Chiou, Guan-Tarn Huang, Hsuan-Shu Lee   +4 more
doaj   +2 more sources

A Polymorphism in Hepatocyte Nuclear Factor 1 Alpha, rs7310409, Is Associated with Left Main Coronary Artery Disease [PDF]

Biochemistry Research International, 2014
Coronary artery disease is the leading cause of mortality and morbidity in the world. Left main coronary artery disease (LMCAD) is a particularly severe phenotypic form of CAD and has a genetic basis.
Rui Liu, Hanning Liu, Haiyong Gu, Xiao Teng, Yu Nie, Zhou Zhou, Yan Zhao, Shengshou Hu, Zhe Zheng   +8 more
doaj   +2 more sources

Gliclazide challenge testing as an alternative diagnostic tool for hepatocyte nuclear factor-1-alpha maturity onset diabetes of the young [PDF]

European Journal of Case Reports in Internal Medicine
Background: Hepatocyte nuclear factor-1-alpha monogenic diabetes (HNF1-alpha DM), formerly known as maturity-onset diabetes of the young type 3 (MODY 3), is often misdiagnosed as type 1 or type 2 diabetes. In regions where genetic testing is unavailable,
Sunjay Pandya, Rutbah Khairati, Jesheen Mann, Lucy Archer, Ponnusamy Saravanan, Fernando Erneta III, Vinod Patel   +6 more
doaj   +2 more sources

Hepatocyte Nuclear Factor 1 and Hypertensive Nephropathy [PDF]

Hypertension, 2008
Hypertension in spontaneously hypertensive rat (SHR) is associated with renal redox stress, and we hypothesized that nephropathy arises in SHR-A3 from altered capacity to mitigate redox stress compared with nephropathy-resistant SHR lines. We measured renal expression of redox genes in distinct lines of the spontaneously hypertensive rat (SHR-A3, SHR ...
Renata I, Dmitrieva, Cruz A, Hinojos, Eric, Boerwinkle, Michael C, Braun, Myriam, Fornage, Peter A, Doris   +5 more
openaire   +2 more sources

Maturity‐onset diabetes of the young type 5, presenting as diabetic ketoacidosis with alkalemia: A report of a case

Journal of Diabetes Investigation, 2022
A 34‐year‐old man visited our Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, because of dry mouth and weight loss.
Akiko Hayakawa‐Iwamoto, Daisuke Aotani, Yuki Shimizu, Shota Kakoi, Chie Hasegawa, Shunsuke Itoh, Asami Fujii, Katsushi Takeda, Takashi Yagi, Hiroyuki Koyama, Kenro Imaeda, Kandai Nozu, China Nagano, Hiromi Kataoka, Tomohiro Tanaka   +14 more
doaj   +1 more source

Hepatocyte Growth Factor-Dependent Antiviral Activity of Activated cdc42-Associated Kinase 1 Against Hepatitis B Virus

Frontiers in Microbiology, 2021
Activated cdc42-associated kinase 1 (ACK1) is a well-known non-receptor tyrosine kinase that regulates cell proliferation and growth through activation of cellular signaling pathways, including mitogen-activated protein kinase (MAPK).
Hye Won Lee, Yongwook Choi, Ah Ram Lee, Cheol-Hee Yoon, Kyun-Hwan Kim, Byeong-Sun Choi, Yong Kwang Park   +6 more
doaj   +1 more source