Results 121 to 130 of about 135,741 (328)

Prolyl-4-Hydroxylase 2 Potentially Contributes to Hepatocellular Carcinoma-Associated Erythrocytosis by Maintaining Hepatocyte Nuclear Factor-4α Expression

Cellular Physiology and Biochemistry, 2015
Background: Increased red blood cell count (Erythrocytosis) is an important paraneoplastic syndrome of hepatocellular carcinoma (HCC) and is a significant risk factor for lethal lung artery thromboembolism.
Wenwen Sun, Friederike Katharina Kosyna, Wolfgang Jelkmann, Reinhard Depping   +3 more
doaj   +1 more source

Hepatocyte nuclear factor 4 alpha (HNF4α) knockdown stimulates pro‐mitogenic gene expression in hepatocytes

The FASEB Journal, 2011
HNF4α, the master regulator of hepatocyte differentiation, has been recently shown to inhibit hepatocyte proliferation via yet to be identified mechanisms.
Chad Michael Walesky, Sumedha Gunewardena, Ernest F. Terwilliger, Genea Edwards, Andy Wolfe, Udayan Apte   +5 more
openaire   +1 more source

Strawberry Notch 1 Acts as a Transcriptional Regulator Driving Oncogenic Programs in Liver Carcinogenesis

Advanced Science, EarlyView.
This study reports that SBNO1 protein is upregulated in several cancer entities. SBNO1 protein interacts with the basal transcription factor TFIID via TAF4, enabling its recruitment to transcription start sites and the modulation of target gene expression.
Sarah Fritzsche, Raisatun Nisa Sugiyanto, Kira Gür, Alina Krumme, Maxime Le Marois, Angelika Fraas, Aslihan Inal, Mario Huerta, Vanessa Henriques, Eva Eiteneuer, Thomas Albrecht, Alphonse Charbel, Michael T. Dill, Carsten Sticht, Carolina De La Torre, Stefan Pusch, Arianeb Mehrabi, Kai Breuhahn, Junfang Ji, Peter Schirmacher, Benjamin Goeppert, Stephanie Roessler   +21 more
wiley   +1 more source

Reversible Nuclear-Lipid-Droplet Morphology Induced by Oleic Acid: A Link to Cellular-Lipid Metabolism [PDF]

, 2017
Neutral lipidsÐinvolved in many cellular processesÐare stored as lipid droplets (LD), thosemainly cytosolic (cLD) along with a small nuclear population (nLD).
Garcia, Margarita Maria, Lagrutta, Lucía Carolina, Layerenza, Juan Pablo, Montero Villegas, Sandra, Sisti, Martin Sebastian, Ves Losada, Ana   +5 more
core   +3 more sources

METTL1‐Mediated M7G tRNA Modification Promotes Residual Liver Regeneration After Hepatectomy via Translational Control

Advanced Science, EarlyView.
METTL1 and its mediated m7G tRNA modification are significantly up‐regulated after partial hepatectomy (PHx). Overexpression of METTL1 improves the efficiency of liver regeneration after PHx, increases the proliferation of hepatocytes, and accelerates the recovery of liver function.
Manling Huang, Shuirong Lin, Yutong Zhao, Jiale Chen, Linyuan Huang, Yuyao Liu, Zixin Huang, Dongxin An, Yifan Zhang, Zimin Song, Xi Yu, Yunpeng Hua, Jing Wang, Weiwei Wang, Yu Guo, Ming Kuang, Fang Wang, Shuibin Lin, Shunli Shen   +18 more
wiley   +1 more source

GLP-1 RA and dual GIP/GLP-1 RA treatment in MODY: a descriptive case series

BMJ Open Diabetes Research & Care
Introduction Glucagon-like peptide-1 receptor agonists (GLP-1 RA) and dual glucose insulinotropic polypeptide (GIP)/GLP-1 RA are widely prescribed, but their effectiveness in different subtypes of maturity-onset diabetes of the young (MODY) is unknown ...
William H Herman, Elif A Oral, Rochelle N Naylor, Brigid Gregg, Alina Z Mehdi, Lily Deng, Colby L Chase, Maria Cristina Foss-Freitas, Mansa Krishnamurthy, David T Broome   +9 more
doaj   +1 more source

The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition [PDF]

, 2016
The transcription factor Snail is a master regulator of cellular identity and epithelial-to-mesenchymal transition (EMT) directly repressing a broad repertoire of epithelial genes.
A Kuzmichev, A Tramontano, AM Khalil, C Battistelli, C Battistelli, C Chu, C Cicchini, C Cicchini, C Cicchini, C Cicchini, C Cicchini, C Cifuentes-Rojas, C Davidovich, CA McHugh, CL Tien, E Bolotin, F Garibaldi, F J Gonzalez, G Deb, G Grassi, H Peinado, H Peinado, J Chen, J Yang, J Zhao, JA Simon, JL Rinn, JP Thiery, KD Nolan, L Amicone, L Amicone, L Grassi, L Li, L Santangelo, L Santangelo, M Colletti, M Courel, M Kretz, M Rodriguez, M Tripodi, M Yu, MA Nieto, MA Perez-Moreno, MC Tsai, OG McDonald, P Arnold, P Wongtrakoongate, Q Cao, R Cao, R Kogo, RA Gupta, RY Huang, S Fujii, S Javaid, S Kaneko, S Lamouille, TD Schmittgen, V de Nonno, Y Chen, Y Lin, Y Nie, Y Yonemitsu, YJ Geng, Z Hou, Z Yang, ZT Tong   +65 more
core   +2 more sources

Hepatocyte Nuclear Factor 4 alpha (HNF4α) Knockdown Stimulates Pro‐Mitogenic Gene Expression in Hepatocytes

The FASEB Journal, 2012
HNF4α, the master regulator of hepatocyte differentiation, has been shown to inhibit hepatocyte proliferation via yet to be identified mechanisms. We investigated the mechanisms of HNF4α‐induced inhibition of hepatocyte proliferation using two novel HNF4α knockdown mouse models.
Chad Michael Walesky, Sumedha Gunewardena, Genea Edwards, Udayan Apte   +3 more
openaire   +1 more source

Expandable Nanocomposite Shape‐Memory Hemostat for the Treatment of Noncompressible Hemorrhage

Advanced Science, EarlyView.
A nanocomposite‐coated shape memory foam rapidly expands, accelerates clotting, and reduces blood loss in vivo. Its fast volumetric expansion and strong procoagulant activity make it a promising hemostat for treating deep, noncompressible hemorrhage.
Saptarshi Biswas, Sarah E. Miller, Shounak Roy, Jeevika Thazhaiselvam, Samantha Foster, Manivannan Sivaperuman Kalairaj, Sasha M. George, Yava Jones‐Hall, Staci J. Horn, Fred J. Clubb, Taylor H. Ware, Duncan J. Maitland, Akhilesh K. Gaharwar   +12 more
wiley   +1 more source

Efficient Production of Hepatocyte-like Cells from Human-induced Pluripotent Stem Cells by Optimizing Growth Factors

International Journal of Organ Transplantation Medicine, 2018
Background: Generating hepatocytes with complete liver functions is still a challenge and developing more functional hepatocytes is needed. Objective: To compare various differentiation factors and protocols and introducing a preferable protocol to ...
Z Jaafarpour, M Soleimani, S Hosseinkhani, M H Karimi, P Yaghmaei, N Mobarra, B Geramizadeh   +6 more
doaj