Results 241 to 250 of about 135,741 (328)

Adropin modulates pancreatic cell proliferation and glutathione levels in an animal model of type 1 diabetes mellitus

Animal Models and Experimental Medicine, EarlyView.
Adropin is related to the energy homeostasis‐associated gene. It significantly increased glutathione reductase enzyme levels in the pancreas of experimental diabetic rats. Adropin may reduce the severity of diabetes and its complications. Cell proliferation in the exocrine is reduced after the administration of adropin.
Ifrah I. Ali, Crystal D'Souza, Abderrahim Nemmar, Shreesh Ojha, Ernest A. Adeghate   +4 more
wiley   +1 more source

Hepatocyte Nuclear Factor 4-Alpha Is Essential for the Active Epigenetic State at Enhancers in Mouse Liver. [PDF]

Hepatology, 2019
Thakur A, Wong JCH, Wang EY, Lotto J, Kim D, Cheng JC, Mingay M, Cullum R, Moudgil V, Ahmed N, Tsai SH, Wei W, Walsh CP, Stephan T, Bilenky M, Fuglerud BM, Karimi MM, Gonzalez FJ, Hirst M, Hoodless PA.   +19 more
europepmc   +1 more source

Characterization of inflammatory pseudotumors in a large animal model of liver cancer

Animal Models and Experimental Medicine, EarlyView.
CT images in arterial and portal venous phases of liver lesions in Oncopig. Abstract Background The development of relevant and robust large animal models of hepatocellular carcinoma is needed to test new therapeutic strategies for this disease. Transgenic approaches hold promise in addressing this complex problem. One such model, the Oncopig, has been
Erik N. K. Cressman, Samantha Hicks, Natalie W. Fowlkes, Danielle L. Stolley, Maria Sophia Stenkamp   +4 more
wiley   +1 more source

A Nonviral Neo‐Nucleocapsid for Cell‐Specific RNA Delivery Developed by Pseudo‐Cyclic Peptide Grafting and Directed Evolution

Angewandte Chemie, EarlyView.
Nonviral neo‐nucleocapsids developed from a repurposed bacterial protein cage, and macrocyclic peptide pharmacophores via protein‐protein ligation, bacteria‐based directed evolution, lasso‐grafting, and mammalian cell‐based directed evolution enabled cell specific RNA delivery.
Daiki Kanayama, Naohiro Terasaka, Kazuki Kato, Sae Okazaki, Hiroaki Suga   +4 more
wiley   +2 more sources

Quantitative proteomics identifies clusterin as a novel biomarker for atherosclerosis

Animal Models and Experimental Medicine, EarlyView.
This schematic illustrates the proposed mechanism. In advanced atherosclerotic lesions, upregulated CLU on the cell surface activates low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1). This interaction triggers the phosphorylation and activation of AKT.
Dengfeng Ding, Yingjie Zhang, Li Zhang, Xinou Zheng, Miaomiao Niu, Yunxiao Jia, Xuezhuang Li, Hua Chen, Chao Guo, Tao Jiang, Yuqiong Zhao   +10 more
wiley   +1 more source

The DNA Binding Domain of Hepatocyte Nuclear Factor 4 Mediates Cooperative, Specific Binding to DNA and Heterodimerization with the Retinoid X Receptor α

, 1997
Guoqiang Jiang, Frances M. Sladek
openalex   +1 more source

PTU-156 Hepatocyte Nuclear Factor 4 Alpha (hnf4a) Is Demonstrated In Barrett’s Metaplasia, But Not In Normal Human Oesophagus [PDF]

, 2014
LP Griffiths, Zoë D. Burke, JM Farrant, Benjamin J. Colleypriest, David Tosh   +4 more
openalex   +1 more source

Skeletal Muscle Biomarkers of Amyotrophic Lateral Sclerosis: A Large‐Scale, Multi‐Cohort Proteomic Study

Annals of Neurology, EarlyView.
Objective Biomarkers with clear contexts of use are important tools for amyotrophic lateral sclerosis (ALS) therapy development. Understanding their longitudinal trajectory in the untreated state is key to their use as potential markers of pharmacodynamic response.
Oleksandr Dergai, Joanne Wuu, Magdalena Koziczak‐Holbro, Andrea Malaspina, Volkan Granit, Jessica P. Hernandez, Anne Cooley, Ruchika Sachdev, Lili Yu, Michael Bidinosti, Ludivine Flotte, Mark Nash, Lori L. Jennings, James D. Berry, Lucie I. Bruijn, Sophie Brachat, Michael Benatar   +16 more
wiley   +1 more source

Hepatocyte Nuclear Factor 4 alpha (HNF4α) Activation is Essential for Termination of Liver Regeneration [PDF]

, 2018
Ian Huck, Sumedha Gunewardena, Regina Español‐Suñer, Holger Willenbring, Udayan Apte   +4 more
openalex   +1 more source

Redox‐Responsive Mitochondrial Delivery from Functionalized Vascular Stent Surfaces

Advanced NanoBiomed Research, EarlyView.
A redox‐responsive stent surface is engineered to deliver functional mitochondria in response to oxidative stress. Upon exposure to reactive oxygen species, grafted mitochondria are released, internalized by vascular cells, and restore mitochondrial function under stress.
Fang Tang, Brandon C. Applewhite, Bowen Wang, Bin Jiang   +3 more
wiley   +1 more source