Results 271 to 280 of about 135,741 (328)
Computer‐Aided Functional Oligosaccharide Screening and the Regulatory Role in Lipid Metabolism
ABSTRACT This study investigated the lipid‐lowering effects and intervention mechanisms of structurally diverse functional oligosaccharides on non‐alcoholic fatty liver disease (NAFLD). By integrating computational tools such as molecular docking and molecular dynamics simulations (MDS), a comprehensive “in silico‐in vitro‐in vivo” tri‐dimensional ...
Rui Jing +3 more
wiley +1 more source
Synergistic isoflavone‐probiotic action modulated metabolic, microbial and ovarian pathway ABSTRACT Polycystic ovary syndrome (PCOS) is a prevalent metabolic–endocrine disorder characterized by insulin resistance, hyperandrogenism, chronic inflammation, oxidative stress, and ovarian dysfunction, with growing evidence implicating gut microbiota ...
Jeyavelkumaran Renukadevi +4 more
wiley +1 more source
After collecting Musa paradisiaca leaves, some were dried and others were used to produce aqueous extracts. The extracts and powders were characterized and then administered to rats made anaemic by PHZ. After 14 days of administration of the two samples, the rats were euthanized and it was observed that after 9 days of treatment, the aqueous extract ...
Josée Rebeca Nombo +8 more
wiley +1 more source
Cardamonin upregulate sd the intestinal metabolite columbianetin acetate, which competitively bound HMGB1 to prevent LPS‐induced renal tubular cell pyroptosis (the figure is created with BioRender). ABSTRACT Sepsis‐associated acute kidney injury (SA‐AKI) results in high mortality due to the lack of effective interventions. The current study reports the
Zihui Zhou +6 more
wiley +1 more source
A schematic illustration for the protective effects of AOS on OTA‐induced liver injury in mice. AOS, alginate oligosaccharides; CAT, catalase; GSTT1, glutathione S‐transferase theta 1; HO‐1, heme oxygenase 1; IκBα, inhibitor kappa B alpha; IL‐1β, interleukin‐1β; IL‐6, interleukin‐6; Keap1, kelch‐like ech‐associated protein 1; NF‐κB, nuclear factor ...
Yue Zhao +8 more
wiley +1 more source
The graphical abstract summarizes the experimental workflow: (1) Preparation of selenium‐containing tea‐derived peptides (TSE‐PP) guided by ADH activation; (2) Purification and LC‐MS/MS identification of selenium‐modified peptides; (3) Molecular docking to reveal peptide‐ADH interactions; (4) Evaluation of hangover‐alleviating and hepatoprotective ...
Lixia Zan +7 more
wiley +1 more source
Insect‐Derived Bioactives for Glycemic Control and Gut Health: A Review
Insect‐derived bioactive compounds (e.g., peptides, polysaccharides) effectively regulate blood glucose through dual mechanisms: directly inhibiting carbohydrate‐digesting enzymes and glucose transporters, and indirectly modulating gut microbiota to enhance intestinal barrier integrity.
Chaoyi Lv +5 more
wiley +1 more source
The effect of microtubular inhibitors on secretion from liver into blood plasma and bile [PDF]
Gratzl, Manfred, Schwab, D.
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