Results 21 to 30 of about 135,741 (328)
Hepatocytic Activating Transcription Factor 3 Protects Against Steatohepatitis via Hepatocyte Nuclear Factor 4α [PDF]
Diabetes, 2021 Activating transcription factor 3 (ATF3) has been shown to play an important role in HDL metabolism; yet, the role of hepatocytic ATF3 in the development of steatohepatitis remains elusive. Here we show that adenoassociated virus-mediated overexpression of human ATF3 in hepatocytes prevents diet-induced steatohepatitis in C57BL/6 mice and reverses ...
Yanyong Xu +7 more
openaire +2 more sources
The Hepatocyte Nuclear Factor 4 (HNF-4) Represses the Mitochondrial HMG-CoA Synthase Gene [PDF]
Biochemical and Biophysical Research Communications, 1998 We have recently shown that the gene for the mitochondrial HMG-CoA synthase is a target for PPAR and that this receptor mediates the induction of this gene by fatty acids. With the aim of gaining further insight into the function and regulation of this gene we examined the effect of other members of the nuclear hormone receptor superfamily on its ...
Joan C. Rodrı x guez +3 more
openalex +5 more sources
Hepatocyte nuclear factor-4 prevents silencing of hepatocyte nuclear factor-1 expression in hepatoma x fibroblast cell hybrids [PDF]
Nucleic Acids Research, 1997 Hepatocyte nuclear factors-1alpha (HNF1alpha) and -4 (HNF4) are components of a liver-enriched transcription activation pathway which is thought to play a critical role in hepatocyte-specific gene expression, including activation of alpha1-antitrypsin gene expression.
Gary A. Bulla
openalex +4 more sources
HNF4A (Hepatocyte Nuclear Factor 4 alpha) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018 Hepatocyte nuclear factor 4 alpha (HNF4A) also known as NR2A1 (Nuclear Receptor Subfamily 2, group A, member 1) is a member of the nuclear receptor (NR) superfamily of ligand-dependent transcription factors. The encoded protein controls the expression of several genes, especially those that play distinct roles in development, differentiation ...
Tunçer, Sinem, Banerjee, Sreeparna
openaire +2 more sources
Human Hepatocyte Nuclear Factor 4-α Encodes Isoforms with Distinct Transcriptional Functions. [PDF]
Mol Cell Proteomics, 2020 HNF4α is a nuclear receptor produced as 12 isoforms from two promoters by alternative splicing. To characterize the transcriptional capacities of all 12 HNF4α isoforms, stable lines expressing each isoform were generated. The entire transcriptome associated with each isoform was analyzed as well as their respective interacting proteome.
Lambert É +10 more
europepmc +4 more sources
Tissue-specific expression of the gene encoding hepatocyte nuclear factor 1 may involve hepatocyte nuclear factor 4. [PDF]
Genes & Development, 1991 Hepatocyte nuclear factor 1 (HNF-1) is a transcriptional regulatory protein possibly involved in the activation of many liver-specifically expressed genes. HNF-1 mRNA is restricted to a small number of tissues, suggesting that the HNF-1 gene itself is regulated at the transcriptional level. We have isolated and characterized the promoter region of this
Tian, Jian-Min, Schibler, Ulrich
openaire +3 more sources
Biomolecules, 2020 Oligo-fucoidan, a sulfated polysaccharide extracted from brown seaweed, exhibits anti-inflammatory and anti-tumor effects. However, the knowledge concerning the detailed mechanism of oligo-fucoidan on liver cells is obscure. In this study, we investigate
Chun-Chia Cheng +5 more
doaj +1 more source
Regulation of hepatic microRNA expression by hepatocyte nuclear factor 4 alpha. [PDF]
World J Hepatol, 2017 To uncover the role of hepatocyte nuclear factor 4 alpha (HNF4α) in regulating hepatic expression of microRNAs.Microarray and real-time PCR were used to determine hepatic expression of microRNAs in young-adult mice lacking Hnf4α expression in liver (Hnf4α-LivKO).
Lu H, Lei X, Liu J, Klaassen C.
europepmc +3 more sources
Generation of Inhibitory Mutants of Hepatocyte Nuclear Factor 4 [PDF]
European Journal of Biochemistry, 1997 Hepatocyte nuclear factor 4 (HNF‐4) is a member of the nuclear‐receptor gene superfamily. HNF‐4 binds to response elements of several liver‐enriched genes and exhibits a restricted pattern of expression, suggesting an important role for HNF‐4 in tissue‐specific gene regulation. Here, we report the generation of three mutated forms of the HNF‐4 protein,
S, Taraviras, G, Schütz, G, Kelsey
openaire +2 more sources
Structural insights into the HNF4 biology
Frontiers in Endocrinology, 2023 Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear receptor (NR) family that is expressed in liver, kidney, intestine and pancreas.
Brice Beinsteiner +11 more
doaj +1 more source