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<p>Collagen III regulates the termination of liver regeneration by suppressing hepatocyte proliferation and promoting functional recovery</p>. [PDF]
Mol Med RepPeng H +6 more
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Liver Progenitor Cells: Cellular Origins, Plasticity, and Signaling Pathways in Liver Regeneration. [PDF]
Biology (Basel)Han J, Sung A, Jeong H, Jung Y.
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A novel isoform of rat hepatocyte nuclear factor 4 (HNF-4)
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1992Based on the published nucleotide sequence for rat hepatocyte nuclear factor 4 (HNF-4; Sladek, F.M., Zhong, W., Lai, E. and Darnell, J.E., Jr. (1990) Genes Dev. 4, 2353-2365), we have cloned a cDNA by means of polymerase chain reaction amplification of reverse-transcribed RNA (RT-PCR).
S, Hata, T, Tsukamoto, T, Osumi
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Role of Hepatocyte Nuclear Factor 4 Alpha (HNF4α) in Hepatocyte Regeneration
The FASEB Journal, 2016Hepatocyte nuclear factor 4 alpha (HNF4α) is the master regulator of hepatic differentiation because it regulates over 60% of genes involved in hepatocyte specific function. Recent studies from our laboratory have revealed a novel role of HNF4α in regulation of hepatocyte quiescence.
Ian Huck, Michael W. Manley, Udayan Apte
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Serine/Threonine Phosphorylation of Orphan Receptor Hepatocyte Nuclear Factor 4
Archives of Biochemistry and Biophysics, 1997We showed previously that hepatocyte nuclear factor 4 (HNF-4) defines a new subclass, Group IV, of nuclear receptors. In order to determine whether members of this subclass are phosphorylated, HNF-4 was overexpressed to high levels in insect cells using a baculovirus expression system.
G, Jiang +3 more
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Role of hepatocyte nuclear factor 4 alpha (HNF4α) in hepatocyte regeneration
The FASEB Journal, 2017Liver has remarkable capacity to regenerate upon surgical resection or chemical injury, which is critical for liver homeostasis. Recent studies have shown that HNF4α, the master regulator of hepatic differentiation, inhibits hepatocyte proliferation. However, the role of HNF4α in liver regeneration is not known.
Ian Huck, Udayan Apte
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Hepatocyte nuclear factor‐4 alpha in noise‐induced cochlear neuropathy
Developmental Neurobiology, 2016ABSTRACTNoise‐induced hearing loss (NIHL) is a problem of profound clinical significance and growing magnitude. Alarmingly, even moderate noise levels, previously assumed to cause only temporary shifts in auditory thresholds (“temporary” NIHL), are now known to cause cochlear synaptopathy and subsequent neuropathy.
Jane Bjerg, Groth +3 more
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A First-in-Class Hepatocyte Nuclear Factor 4 Agonist
Journal of Medicinal ChemistryHepatocyte nuclear factor 4 (HNF4) is an orphan nuclear receptor implicated, for example, in pancreatic islet gene expression and hepatic regulation of glucose and lipid metabolism. Mutations in the HNF4α gene are responsible for the inheritable maturity-onset diabetes of the young 1 (MODY-1), supporting the therapeutic potential of HNF4 activation in ...
Espen Schallmayer +10 more
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Hepatocyte nuclear factor 4 in epithelial development and carcinogenesis
Molecular Biology, 2008Hepatocyte nuclear factors (HNFs) play a key role in the establishment and maintenance of hepatocyte differentiation. Not only do HNFs control the expression of functional liver-specific genes, but they are also involved in regulating cell proliferation, morphogenesis, and detoxification in the liver. The review considers the main biological properties
N. L. Lazarevich, D. V. Alpern
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