Results 301 to 310 of about 135,741 (328)

Regulation of Hepatocyte Nuclear Factor 4α-mediated Transcription

Drug Metabolism and Pharmacokinetics, 2008
Hepatocyte nuclear factor 4alpha (HNF4alpha, NR2A1) is required for development of the liver and for controlling the expression of many genes specifically expressed in the liver and associated with a number of critical metabolic pathways.
openaire   +2 more sources

Role of Hepatocyte Nuclear Factor 4 Alpha in Liver Cancer

Seminars in Liver Disease
Liver cancer is the sixth most common cancer and the fourth leading cause of cancer-related deaths worldwide. Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer and the incidence of HCC is on the rise. Liver cancers in general and HCC in particular do not respond to chemotherapy.
Manasi, Kotulkar, Diego, Paine-Cabrera, Udayan, Apte   +2 more
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Estrogen‐Inducible Derivatives of Hepatocyte Nuclear Factor‐4, Hepatocyte Nuclear Factor‐3 and Liver Factor B1 are Differently Affected by Pure and Partial Antiestrogens

European Journal of Biochemistry, 1994
The tissue‐specific transcription factors of the hepatocyte nuclear factor‐4 (HNF4), hepatocyte nuclear factor‐3 (HNF3), and liver factor B1 (LFB1) families are thought to play a role in the development of internal organs and in the tissue‐specific expression of many distinct genes.
T, Drewes, A, Clairmont, L, Klein-Hitpass, G U, Ryffel   +3 more
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Hepatocyte nuclear factor 4 (HNF4) binding sites in the salmon HNF1 promoter

Gene, 1996
We report the isolation and sequencing of a 1100-bp DNA fragment containing the salmon Hepatocyte Nuclear Factor 1 gene (sHNF1) promoter. The sHNF1 promoter cloned upstream of the chloramphenicol acetyl transferase (CAT) encoding gene is shown to be active in two cell lines of hepatic origin.
Deryckere, F., Mcnair, A., Gannon, F.
openaire   +3 more sources

Hepatocyte nuclear factor-4??/?? and hepatocyte nuclear factor-1?? as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers

Pharmacogenetics, 2003
Human dihydrodiol dehydrogenase (DD) catalyses the oxidation of trans-dihydrodiols of polycyclic aromatic hydrocarbons and the reduction of several ketone-containing drugs. About 40-fold interindividual difference in DD activities has been noted. Recently, we found that transcriptional factors, hepatocyte nuclear factor (HNF)-1 alpha, HNF-4 alpha and ...
Takeshi, Ozeki, Yoshiki, Takahashi, Kazuo, Nakayama, Masato, Funayama, Kazuo, Nagashima, Takao, Kodama, Tetsuya, Kamataki   +6 more
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Phenotypic screening of hepatocyte nuclear factor (HNF) 4-γ receptor knockout mice

Biochemical and Biophysical Research Communications, 2006
Using the mouse as a model organism in pharmaceutical research presents unique advantages as its physiology in many ways resembles the human physiology, it also has a relatively short generation time, low breeding and maintenance costs, and is available in a wide variety of inbred strains. The ability to genetically modify mouse embryonic stem cells to
Anna Karin, Gerdin, Vikas V, Surve, Marie, Jönsson, Mikael, Bjursell, Maria, Björkman, Anne, Edenro, Meint, Schuelke, Alaa, Saad, Sivert, Bjurström, Elisabeth Jensen, Lundgren, Michael, Snaith, Ronny, Fransson-Steen, Jan, Törnell, Anna-Lena, Berg, Mohammad, Bohlooly-Y   +14 more
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Laminin-Rich Extracellular Matrix Maintains High Level of Hepatocyte Nuclear Factor 4 in Rat Hepatocyte Culture

Biochemical and Biophysical Research Communications, 1995
Laminin-rich extracellular matrix, EHS-gel, has been demonstrated to keep a high level of liver-specific gene expression in cultured rat hepatocytes. To obtain information about the effect of EHS-gel on liver-specific functions, gene expression of liver-enriched transcription factors in rat hepatocytes was investigated.
H, Oda, K, Nozawa, Y, Hitomi, A, Kakinuma   +3 more
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[Hepatocyte nuclear factor 4 (HNF4) in epithelial development and carcinogenesis].

Molekuliarnaia biologiia, 2009
Hepatocyte nuclear factors play the key role in the establishing and maintenance of hepatocyte differentiation. They not only control the expression of functional hepatic genes but are also involved in the regulation of proliferation, morphogenesis and detoxication in the liver.
N L, Lazarevich, D V, Al'pern
openaire   +1 more source

Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis

Nature Biotechnology, 2023
Delilah F G Hendriks, Jos F Brouwers
exaly  

Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair

Science, 2021
Lingjuan He, Wenjuan Pu, Xiuxiu Liu
exaly