Results 31 to 40 of about 135,741 (328)

Feedback loop between hepatocyte nuclear factor 1α and endoplasmic reticulum stress mitigates liver injury by downregulating hepatocyte apoptosis

Scientific Reports, 2022
Hepatocyte nuclear factor alpha (HNF1α), endoplasmic reticulum (ER) stress, and hepatocyte apoptosis contribute to severe acute exacerbation (SAE) of liver injury. Here, we explore HNF1α–ER stress-hepatocyte apoptosis interaction in liver injury.
Si-Ying Liu, Jian-Xu Rao, Jie Deng, Gui-Juan Zhang, Xiao-Ling Jiang, Jing Cheng, Huan Chen, Zhi-Gang Jiang, De-Lin Xu, Yi-Huai He   +9 more
doaj   +1 more source

TFIIB-Directed Transcriptional Activation by the Orphan Nuclear Receptor Hepatocyte Nuclear Factor 4 [PDF]

Molecular and Cellular Biology, 1996
The orphan nuclear receptor hepatocyte nuclear factor 4 (HNF-4) is required for development and maintenance of the liver phenotype. HNF-4 activates several hepatocyte-specific genes, including the gene encoding apolipoprotein AI (apoAI), the major protein component of plasma high-density lipoprotein.
Sohail Malik, Sotirios K. Karathanasis
openalex   +4 more sources

Tissue-Specific Regulation of Mouse Hepatocyte Nuclear Factor 4 Expression [PDF]

Molecular and Cellular Biology, 1994
Hepatocyte nuclear factor 4 (HNF-4) is a liver-enriched transcription factor and a member of the steroid hormone receptor superfamily. HNF-4 is required for the hepatoma-specific expression of HNF-1 alpha, another liver-enriched transcription factor, suggesting the early participation of HNF-4 in development.
Weimin Zhong, Jovan Mirkovitch, James Darnell   +2 more
openalex   +4 more sources

Inhibition of hepatocyte nuclear factor 4 transcriptional activity by the nuclear factor κB pathway [PDF]

Biochemical Journal, 2006
HNF-4 (hepatocyte nuclear factor 4) is a key regulator of liver-specific gene expression in mammals. We have shown previously that the activity of the human APOC3 (apolipoprotein C-III) promoter is positively regulated by the anti-inflammatory cytokine TGFβ (transforming growth factor β) and its effectors Smad3 (similar to mothers against ...
Varvara, Nikolaidou-Neokosmidou, Vassilis I, Zannis, Dimitris, Kardassis   +2 more
openaire   +2 more sources

Hepatocyte nuclear factor 4 a (HNF4α): A perspective in cancer

Biomedicine & Pharmacotherapy, 2023
HNF4α, a transcription factor, plays a vital role in regulating functional genes and biological processes. Its alternative splicing leads to various transcript variants encoding different isoforms. The spotlight has shifted towards the extensive discussion on tumors interplayed withHNF4α abnormalities.
Ningxin, Qu, Ting, Luan, Naiquan, Liu, Chenhui, Kong, Le, Xu, Hong, Yu, Ye, Kang, Ye, Han   +7 more
openaire   +2 more sources

Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases. [PDF]

World J Gastroenterol, 2019
Hepatocyte nuclear factor 4-alpha (HNF4α) is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription factors that is expressed in liver and gastrointestinal organs (pancreas, stomach, and intestine). In liver, HNF4α is best known for its role as a master regulator of liver-specific gene expression and essential for ...
Yeh MM, Bosch DE, Daoud SS.
europepmc   +3 more sources

Hepatocyte nuclear factor 4 alpha deletion promotes diethylnitrosamine-induced hepatocellular carcinoma in rodents. [PDF]

Hepatology, 2013
Walesky C, Edwards G, Borude P, Gunewardena S, O'Neil M, Yoo B, Apte U.   +6 more
europepmc   +3 more sources

Age-related changes in bile acid synthesis and hepatic nuclear receptor expression [PDF]

, 2007
BACKGROUND:Recent data highlighted the role of nuclear receptors in the transcriptional regulation of the limiting enzyme of bile acid synthesis, cholesterol 7alpha-hydroxylase, in cellular and animal models.
Anzivino, Claudia, Bertolotti, Marco, Carulli, Lucia, Carulli, Nicola, Crestani, M, De Fabiani, E, Del Puppo, M, Gabbi, C, Godio, C, Loria, P, Macchioni, D, Mitro, N, Ricchi, M, Rossi, Aldo   +13 more
core   +1 more source

Mutations in transcription factor as rare causes of diabetes in pregnancy

Сахарный диабет, 2019
MODY1 and MODY3 represent rare causes of diabetes in pregnancy. Establishing a molecular diagnosis of MODY1 or MODY3 during pregnancy may be important for minimizing risk of perinatal complications and for improving glycemic control after pregnancy.
Natalia A. Zubkova, Fatima F. Burumkulova, Vasily A. Petrukhin, Margarita A. Plechanova, Anton E. Panov, Evgeny V. Vasilyev, Vasily M. Petrov, Nina A. Makretskaya, Anatoliy N. Tyulpakov   +8 more
doaj   +1 more source

The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation [PDF]

, 2018
The expression of the long noncoding RNA HOTAIR (HOX Transcript Antisense Intergenic RNA) is largely deregulated in epithelial cancers and positively correlates with poor prognosis and progression of hepatocellular carcinoma and gastrointestinal cancers.
A Busanello, AL Cattin, AM Cozzolino, C Battistelli, C Battistelli, C Battistelli, C Cicchini, C Cicchini, C Cicchini, C Padua Alves, Carla Cicchini, Cecilia Battistelli, Claudia Montaldo, DW Dodd, E Bolotin, F Garibaldi, F Parviz, Frank J. Gonzalez, Giovanna Sabarese, H Hagege, J Dekker, JA Bonzo, JL Rinn, K Kim, L Amicone, L Santangelo, Laura Santangelo, M Darsigny, MA Battle, Marco Tripodi, MC Tsai, MJ Milevskiy, N Skrypek, NL Lazarevich, R Kogo, RA Gupta, RE Hewitt, S Holwerda, S Satohisa, S Sekiya, SH Ahn, T Oshima, WD Garrison, Y Kamiyama, Y Nie, Y Qiao, Y Ren, YJ Geng, Z Chen, Z Yang, ZH Wu, ZQ Wu   +51 more
core   +1 more source