A Novel HNF4A Mutation Causing Three Phenotypic Forms of Glucose Dysregulation in a Family
Frontiers in Pediatrics, 2020 Maturity-onset diabetes of the young (MODY) classically describes dominantly inherited forms of monogenic diabetes diagnosed before 25 years of age due to pancreatic β-cell dysfunction.
Suresh Chandran +13 more
doaj +1 more source
Core promoter: A critical region where the hepatitis B virus makes decisions [PDF]
, 2014 The core promoter (CP) of the viral genome plays an important role for hepatitis B virus (HBV) replication as it directs initiation of transcription for the synthesis of both the precore and pregenomic (pg) RNAs.
Quarleri, Jorge Fabian
core +1 more source
Hepatocyte Nuclear Factor 4 Is a Transcription Factor that Constitutively Binds Fatty Acids [PDF]
Structure, 2002 The 2.7 A X-ray crystal structure of the HNF4gamma ligand binding domain (LBD) revealed the presence of a fatty acid within the pocket, with the AF2 helix in a conformation characteristic of a transcriptionally active nuclear receptor. GC/MS and NMR analysis of chloroform/methanol extracts from purified HNF4alpha and HNF4gamma LBDs identified mixtures ...
Wisely, G.Bruce +11 more
openaire +2 more sources
The hepatitis E virus ORF3 protein regulates the expression of liver-specific genes by modulating localization of hepatocyte nuclear factor 4. [PDF]
PLoS ONE, 2011 The hepatitis E virus (HEV) is a small RNA virus and the cause of acute viral hepatitis E. The open reading frame 3 protein (pORF3) of HEV appears to be a pleiotropic regulatory protein that helps in the establishment, propagation and progression of ...
Vivek Chandra +5 more
doaj +1 more source
Insulin-inducible SMILE inhibits hepatic gluconeogenesis [PDF]
, 2015 The role of a glucagon/cAMP-dependent protein kinase–inducible coactivator PGC-1α signaling pathway is well characterized in hepatic gluconeogenesis. However, an opposing protein kinase B (PKB)/Akt-inducible corepressor signaling pathway is unknown.
Choi, Byeong Hun +11 more
core +1 more source
Effect of Urtica dioica L extract on quantitative morphometric alterations of liver parenchymal cells in STZ diabetic rats [PDF]
, 2009 Diabetes is associated with several structural and functional liver abnormalities that affect glycogen and lipid metabolism. In this study, an attempt was made to evaluate the effects of hydroalcoholic extract of Urtica dioica leaves on Quantitative ...
Farsi, M.M. +2 more
core +1 more source
A novel technique for selective NF-kappa B inhibition in Kupffer cells: contrary effects in fulminant hepatitis and ischaemia-reperfusion. [PDF]
, 2009 Background and aims: The transcription factor nuclear factor kappa B (NF-kB) has risen as a promising target for anti-inflammatory therapeutics. In the liver, however, NFkB inhibition mediates both damaging and protective effects.
A. Hartkorn +11 more
core +1 more source
Regenerative Therapy, 2016 A heparin-modified thermoresponsive surface bound with heparin-binding epidermal growth factor-like growth factor (HB-EGF) was designed to allow creation of transferrable and functional hepatocyte sheets.
Yoshinori Arisaka +7 more
doaj +1 more source
Development and characterization of a new human hepatic cell line [PDF]
, 2015 The increasing demand and hampered use of primary human hepatocytes for research purposes have urged scientists to search for alternative cell sources, such as immortalized hepatic cell lines.
Berx, Geert +6 more
core +3 more sources
The role of hepatocyte nuclear factor 4α (HNF4α) in tumorigenesis
Frontiers in Oncology, 2022 Hepatocyte Nuclear Factor 4 Alpha (HNF4α) is a master transcription factor mainly expressed in the liver, kidney, intestine and endocrine pancreas. It regulates multiple target genes involved in embryonic development and metabolism.
Lei Sang +8 more
doaj +1 more source