Results 101 to 110 of about 146,077 (348)

Liver dysfunction in patients with IBD under immunosuppressive treatment: do we need to fear? [PDF]

, 2010
International ...
Beaugerie, Laurent, Gerbes, Alexander L.
core   +3 more sources

Synthesis and Biological Evaluation of Bicyclic Pyrazolines with Promising Antimicrobial Activities

ChemMedChem, EarlyView.
Continuous flow technology is exploited for the generation of bicyclic pyrazolines via photo‐click reactions. These heterocyclic species contain a valuable 3D scaffold along with a polar succinimide moiety. Subsequent antimicrobial testing reveals that halogenated moieties such as chlorine atoms and trifluoromethoxy groups enhance the potency of these ...
Debora Caviglia, Anna Maria Schito, Susanna Penco, Chiara Brullo, Marcus Baumann   +4 more
wiley   +1 more source

Intracellular and Extracellular Efficacy of Homoisoflavone Derivatives Against Mycobacterium tuberculosis: Progress Toward Novel Antitubercular Agents

ChemMedChem, Accepted Article.
Tuberculosis (TB) is the leading cause of death among infectious diseases, and new studies focusing new anti‐TB drugs are urgent due to the emergence of drug‐resistant strains. In this regard, homoisoflavones, an underexplored subgroup of flavonoids, were explored for their potential as anti‐TB agents.
Sanderson D. Calixto, Juliane S. Falcão, Stella S. Antunes, Marlon H. Araujo, Alexandre L. B. Cunha, David R. Martins, Sarah M. R. Nascimento, Thatiana L. B. V. Simão, Elena B. Lasunskaia, Nelilma C. Romeiro, Paulo R. R. Costa, Michelle Muzitano, Guilherme S. Caleffi   +12 more
wiley   +1 more source

Oral and Intravenous Acetylcysteine for Treatment of Acetaminophen Toxicity: A Systematic Review and Meta-analysis

Western Journal of Emergency Medicine, 2013
Introduction: There are few reports summarizing the effectiveness of oral and intravenous (IV) acetylcysteine. We determined the proportion of acetaminophen poisoned patients who develop hepatotoxicity (serum transaminase > 1000 IU/L) when treated with ...
Donald Albert, Kate M Reynolds, Kennon J. Heard, Jody L. Green   +3 more
doaj   +1 more source

Low-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 Cascade. [PDF]

, 2020
Saturated fatty acids (SFAs) (the "bad" fat), especially palmitate (PA), in the human diet are blamed for potential health risks such as obesity and cancer because of SFA-induced lipotoxicity. However, epidemiological results demonstrate a latent benefit
Candas-Green, Demet, Chen, Hong-Wu, Fan, Ming, Hu, Yiyang, Jiang, Joy X, Li, Jian Jian, Liu, Lin, Wang, Yinsheng, Wei, Ryan, Xie, Bowen   +9 more
core  

Benzochalcogenodiazoles, Synthesis, and Applications in Medicinal Chemistry and Photomedicine

European Journal of Organic Chemistry, EarlyView.
Benzochalcogenodiazoles (BXD) including benzoxadiazoles, benzothiadiazoles, and benzoselenadiazoles are initially mainly designed for optoelectronic materials as electron‐deficient cores. Nevertheless, they are now extending their application to biology.
Jean‐Elie Zheng, Xavier Franck, Thibault Gallavardin   +2 more
wiley   +1 more source

Incidence of hepatotoxicity of highly active Antiretroviral Therapy in a Tertiary Health Centre in Nigeria.

Nigerian Postgraduate Medical Journal, 2012
Aims and objectives: The aim of this study was to determine the incidence of hepatotoxicity of HAART in HIV infected patients in a tertiary health centre in Nigeria.
R A Ugiagbe, A O Malu, B J Bojuwoye, A N Onunu   +3 more
doaj  

C-Jun N-terminal kinase 2 promotes liver injury via the mitochondrial permeability transition after hemorrhage and resuscitation [PDF]

, 2012
Hemorrhagic shock leads to hepatic hypoperfusion and activation of mitogen-activated stress kinases (MAPK) like c-Jun N-terminal kinase (JNK) 1 and 2. Our aim was to determine whether mitochondrial dysfunction leading to hepatic necrosis and apoptosis ...
Czerny, Christoph, Lehnert, Mark, Lemasters, John J., Maldonado, Eduardo N., Marzi, Ingo, Theruvath, Tom Prakash, Zhong, Zhi   +6 more
core   +2 more sources

Reflections and insights into the evolution of restrictive eligibility criteria for cancer clinical trials in China and beyond

Cancer Communications, EarlyView.
Huiyao Huang, Huilei Miao, Jinling Tang, Ning Li   +3 more
wiley   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source