Results 111 to 120 of about 137,616 (341)

Oxidative Stress and First-Line Antituberculosis Drug-Induced Hepatotoxicity

Antimicrobial Agents and Chemotherapy, 2018
Hepatotoxicity induced by antituberculosis drugs is a serious adverse reaction with significant morbidity and even, rarely, mortality. This form of toxicity potentially impacts the treatment outcome of tuberculosis in some patients.
W. Yew, K. Chang, D. Chan
semanticscholar   +1 more source

Transcriptomics Guided Engineering of Exosome‐Encapsulated Bifunctional Nanosheets Targeting the Immune‐PI3K/Akt Axis for Osteoporosis Therapy

Advanced Science, EarlyView.
A multifunctional nanosheet–exosome hybrid system incorporating f‐CA(OH) nanosheets enriched with abundant surface vacancies are developed. These nanosheets fuse with natural exosomes, endowing them with nanozyme‐like catalytic capabilities while retaining their inherent biological functions.
Rongze Tang, Guanhong Liu, Congcong Wang, Minghao Chao, Guangyu Ma, Pengjin Wei, Siling Du, Junjie Li, Yufan Liu, Chaonan Jing, Guoquan Wu, Ming Guan, Hongliang Chen, Fenglei Gao   +13 more
wiley   +1 more source

Voriconazole-Induced Hepatotoxicity in a Patient with Pulmonary Aspergillosis: A Case Report

Infection and Drug Resistance, 2023
Li Gu,1 Tao Ai,2 Ling Pang,1 Dong Xu,1 Han Wang3 1Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonostic Infectious Disease, Huazhong University of ...
Gu L, Ai T, Pang L, Xu D, Wang H
doaj  

Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology

Journal of Clinical and Translational Research, 2017
Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the United States and mechanisms of liver injury induced by APAP overdose have been the focus of extensive investigation.
A. Ramachandran, H. Jaeschke
semanticscholar   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

Risk factor for hepatotoxicity in epileptic children with long-term AEDs treatment: A comprehensive analysis [PDF]

Romanian Journal of Neurology
Background and objectives. The use of antiepileptic drugs (AEDs) is often required for extended periods in pediatric patients. However, there is a risk of hepatotoxicity associated with AED use.
Christina Silalahi, Sunny Mariana Samosir, Rendi Aji Prihaningtyas, Prastiya Indra Gunawan, Bagus Setyoboedi   +4 more
doaj   +1 more source

Tissue fractionation studies. 11. Influence of various hepatotoxic treatments on the state of some bound enzymes in rat liver [PDF]

, 1959
Henri Beaufay, E. Van Campenhout, C. De Duve   +2 more
openalex   +1 more source

Synovium‐On‐A‐Chip: Simulating the Microenvironment of the Rheumatoid Arthritis Synovium via Multicell Interactions to Target Fibroblast‐Like Synoviocytes

Advanced Science, EarlyView.
The synovium‐on‐a‐chip (SOC) model establishes a 3D flow‐based co‐culture of rheumatoid arthritis (RA) fibroblast‐like synoviocytes (FLSs) with M1 macrophages and endothelial cells on a microfluidic chip. This model better recapitulates the inflammatory microenvironment of RA synovium and the invasive/proliferative properties of RA FLSs in vivo ...
Wenya Diao, Yi Jiao, Tingting Deng, Jienan Gu, Bailiang Wang, Qidong Zhang, Peilong Wang, Ning Xu, Cheng Xiao   +8 more
wiley   +1 more source

EXTRACTION AND PRELIMINARY CHARACTERIZATION OF A HEPATOTOXIC SUBSTANCE FROM CULTURES OF PENICILLIUM RUBRUM [PDF]

, 1962
Benjamin J. Wilson, Christina H. Wilson
openalex   +1 more source

Self‐Assembled Dictamni Cortex Nanoparticles Ameliorate Psoriasis by Epigenetic Modulation of HSP90AB1 and Suppression of the Inflammatory Response

Advanced Science, EarlyView.
This study develops self‐assembled Dictamni Cortex (BXP)‐Fe(III) infinite coordination polymer nanoparticles (NB) to improve BXP's solubility and bioavailability for psoriasis. NB transdermally treats psoriasis by targeting the epigenetic regulator CTCF (CCCTC‐binding factor), suppressing HSP90AB1 (heat shock protein 90 alpha family class B member 1 ...
Zhengyi Zhang, Wenqian Du, Xiaojiang Zhang, Hongbo Cui, Baochen Cheng, Xiao Han, Ke He, Tingyi Yin, Xinyi Liu, Ningyi Xian, Ziyang Wang, Meng Liu, Dan Han, Jiankang Liu, Yan Zheng, Ya Wang   +15 more
wiley   +1 more source