Results 151 to 160 of about 146,077 (348)

Mechanistic Insights and Pharmacological Approaches for Nitrogen and Sulfur Mustards and Their Implications as Therapeutic Agents

Journal of Applied Toxicology, EarlyView.
ABSTRACT Nitrogen and sulfur mustards, often acting as vesicants, have significant consequences for public health. Skin is a common site for exposure to these vesicants that can result in considerable morbidity and mortality. Given that the treatment options are limited, new insights into the mechanisms for the toxicity of these vesicants that can be ...
Madison Owens, Anita Thyagarajan, Jeffrey B. Travers, Ravi P. Sahu   +3 more
wiley   +1 more source

The safety of herbal medicinal products [PDF]

, 2011
The primary aim of the EU, with the registration of herbal medicinal products (HMPs), is the protection of the European citizens from fraudulent and unsafe products.
Attard, Everaldo
core  

Effects of Hepatic or Renal Impairment on Pharmacokinetics of Fruquintinib

The Journal of Clinical Pharmacology, EarlyView.
Abstract Fruquintinib (FRUZAQLATM) is a highly selective tyrosine kinase inhibitor of all three vascular endothelial growth factor receptors (‐1, ‐2, and ‐3). Two Phase 1, open‐label, single‐dose studies investigated the impact of hepatic or renal impairment on the pharmacokinetics and tolerability of fruquintinib.
Martha Gonzalez, Zhao Yang, William Schelman, Thomas C. Marbury, Juan C. Rondon, William Smith, Xiaofei Zhou, Neeraj Gupta, Caly Chien   +8 more
wiley   +1 more source

Hepatotoxicity and Halothane Metabolism in an Animal Model with Application for Human Toxicity [PDF]

, 1979
Michael J. Cousins, James H. Sharp, Geoffrey K. Gourlay, John Adams, W.D.G. Haynes, Richard Whitehead   +5 more
openalex   +1 more source

Hepatotoxicity during TB treatment in people with HIV/AIDS related to NAT2 polymorphisms in Pernambuco, Northeast Brazil

Annals of Hepatology, 2020
Introduction and objective: Hepatotoxicity during tuberculosis (TB) treatment is frequent and may be related to the Arylamine N-Acetyltransferase (NAT2) acetylator profile, in which allele frequencies differ according to the population.
Carolline Araujo-Mariz, Maria de Fátima P. Militão de Albuquerque, Edmundo P. Lopes, Ricardo A.A. Ximenes, Heloísa R. Lacerda, Demócrito B. Miranda-Filho, Brena B. Lustosa-Martins, André Filipe P. Pastor, Bartolomeu Acioli-Santos   +8 more
doaj  

TIPS and HCC: friends or foes ? [PDF]

, 2016
Portal hypertension and hepatocellular carcinoma [HCC] are major complications of liver cirrhosis and may coexist in the same patient. Transjugular intrahepatic portosystemic shunt [TIPS] is an effective treatment for recurrent variceal bleeding
DE SANTIS, Adriano
core  

Vitamin E and hepatotoxic agents [PDF]

, 1970
Michael A. Cawthorne, J. Bunyan, Matthew V. Sennitt, J. Green, P. Grasso   +4 more
openalex   +1 more source

ESPGHAN/NASPGHAN guidelines for treatment of irritable bowel syndrome and functional abdominal pain‐not otherwise specified in children aged 4–18 years

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Abdominal pain related disorders of gut–brain interaction (AP‐DGBIs) such as irritable bowel syndrome (IBS) and functional abdominal pain‐not otherwise specified (FAP) are common conditions in children, significantly impacting quality of life.
Jip Groen, Morris Gordon, Ashish Chogle, Marc Benninga, Rachel Borlack, Osvaldo Borrelli, Anil Darbari, Jernej Dolinsek, Julie Khlevner, Carlo Di Lorenzo, Hannibal Person, Rinarani Sanghavi, Julie Snyder, Nikhil Thapar, Arine Vlieger, Vasiliki Sinopoulou, Merit Tabbers, Miguel Saps   +17 more
wiley   +1 more source

Allergy to iprindole (Prondol) with hepatotoxicity. [PDF]

, 1970
Jaqueline Price, J A Collings-Wells
openalex   +1 more source

Therapeutic drug monitoring and pharmacogenomic guided perhexiline therapy in kidney failure requiring haemodialysis: a case study

Journal of Pharmacy Practice and Research, EarlyView.
Abstract Background Ischaemic heart disease is a leading cause of morbidity and mortality in haemodialysis patients, yet conventional therapies are often precluded due to increased perioperative risk and medication contraindications. Perhexiline, an antianginal agent, is contraindicated in renal impairment.
Harry Ashton, Hemant Kulkarni
wiley   +1 more source