Results 201 to 210 of about 160,647 (335)

Interpretable machine learning enables early and accurate detection of drug‐induced liver injury: A multicenter study with real‐world clinical translation

Interdisciplinary Medicine, EarlyView.
This study develops an interpretable gradient‐boosting model that accurately identifies drug‐induced liver injury (DILI) using routine laboratory data. The model explains key clinical features through SHapley Additive exPlanations analysis and detects DILI earlier than expert evaluation, offering a transparent and practical tool for precision ...
Jingyi Ling, Shian Zhang, Jun Lin, Zhengju Xu, Runcheng Xu, Qian Lv, Kaixiang Zhang, Sheng Liu, Jie Guo, Cheng Hua, Yin Jia, Xiaoyu Xu, Kun Qian, Shanrong Liu   +13 more
wiley   +1 more source

Navigating hepatotoxicity of antibody-drug conjugates: from mechanistic insights to clinical and postmarketing evidence. [PDF]

Front Pharmacol
Dong Y, Zhi Y, Li X, Ma M, Ye M, Huang S, Tang J, Zhong W, Lei X, Mao Y.   +9 more
europepmc   +1 more source

Toxicidad hepática inducida por amoxicilina Hepatotoxicity induced by amoxicillin

, 2007
Ana Belén Madroñero, J. M. Porcel, S. Bielsa   +2 more
openalex   +1 more source

Effective Treatment of Hepatotoxicity due to Mushroom Poisining with Therapeutic Plasma Exchange

, 2020
Nihal Akçay, Ülkem Koçoğlu Barlas, Kübra Boydağ Güvenç, Güner Özçelik, Esra Şevketoğlu   +4 more
openalex   +1 more source

Evaluation of Acephate Metabolites Generated by Zebrafish (Danio rerio) Using LC–HRMS and Metabolomics Approach

Journal of Applied Toxicology, EarlyView.
ABSTRACT Acephate is an organophosphate insecticide widely used. This pesticide can be metabolized into methamidophos, a molecule highly toxic. Both have demonstrated the ability to promote serious toxic effects on nontarget organisms and have been identified in surface waters around the world. Therefore, it is important to understand their behavior in
Mariana Laiz Silva de Lima, Lucas Rodrigues Cunha, Karina Taciana Santos Rubio, Maria Elvira Poleti Martucci   +3 more
wiley   +1 more source

Human Leukocyte Antigen (<i>HLA</i>) Signatures and Idiosyncratic Drug-Induced Liver Injury. [PDF]

Int J Mol Sci
Onaciu A, Grama A, Agoșton Ș, Mititelu A, Mariş B, Ştefănescu H, Pop TL.   +6 more
europepmc   +1 more source

Nanoformulation of cinnamon oil/usnic acid blend: - An attempt to improve chemopreventive effect and reduce hepatotoxicity [PDF]

, 2020
Sunil Kumar Singh, Alok Mukerjee, Ashok Pandey, Abhishek Tripathi   +3 more
openalex  

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

Journal of Applied Toxicology, EarlyView.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu, Bing Liu, Keli Wang, Xiaoyu Wang, Zhen Sun, Xiaojuan Pan, Zengming Zhao   +6 more
wiley   +1 more source

Hierarchical Mechanistic Modeling of Complex Toxicity Endpoints from Public Concentration-Response Data. [PDF]

Environ Sci Technol
Chung E, Russo DP, Aleksunes LM, Warner GR, Zhu H.   +4 more
europepmc   +1 more source

Hepatoprotective effect of leaves of aqueous ethanol extract of <i>Cestrum nocturnum</i> against paracetamol-induced hepatotoxicity

, 2014
Muhammad Imran Qadir, Muhammad Sajid Al Murad, Muhammad Ali, Mohammad Saleem, Ammad Ahmad Farooqı   +4 more
openalex   +2 more sources