Results 201 to 210 of about 146,077 (348)

MMF Is an Effective and Safer Treatment Options for Treatment‐Naïve Patients With Autoimmune Hepatitis Compared to Azathioprine: A Systematic Review and Meta‐Analysis

Journal of Digestive Diseases, EarlyView.
Mycophenolate mofetil (MMF) demonstrates superior efficacy and tolerability compared to azathioprine (AZA) in treatment‐naïve autoimmune hepatitis (AIH) patients. Meta‐analysis of five studies reveals higher complete biochemical response rates, increased Corticosteroid withdrawal rate, and fewer gastrointestinal side effects with MMF.
Muhammad Tayyab Anwar, Muhammad Shahzil, Taha Bin Arif, Muhammad Ali Khaqan, Edzel Lorraine Co, Fariha Hasan, Rameez Tarar, Hamza Naeem, Sibgha Farooq, Ali Jaan, Ammad Javaid Chaudhary, Vinay Jahagirdar, Reena Salgia   +12 more
wiley   +1 more source

The Adverse Effects of Tuberculosis Treatment: A Comprehensive Literature Review. [PDF]

Medicina (Kaunas)
Mereškevičienė R, Danila E.
europepmc   +1 more source

Ultrastructure of experimental cocaine hepatotoxicity [PDF]

, 1986
Marcia R. Gottfried, Michelle W. Kloss, Doyle G. Graham, Elmer J. Rauckman, Gerald M. Rosen   +4 more
openalex   +1 more source

Circular RNA Telomerase Reverses Endothelial Senescence in Progeria

Aging Cell, EarlyView.
TERT circRNA outperforms linear TERT mRNA in reversing the hallmarks of senescence. TERT circRNA more efficiently restores endothelial function and shows superior capability in enhancing mitochondrial function. ABSTRACT Telomeres shorten with each cell division, acting as a chronometer of cell age. The enzyme telomerase, primarily active in stem cells,
Weifeng Qin, Kathrina D. Castillo, Hongye Li, Thi Kim Cuc Nguyen, Daniel L. Kiss, John P. Cooke, Anahita Mojiri   +6 more
wiley   +1 more source

Case Report: Fatal presumptive idiosyncratic hepatic necrosis secondary to standard-dose leflunomide administration in a dog. [PDF]

Front Vet Sci
Aponte-Colon C, Cochran LA, Harris L, Mears EA, Frederick SW.   +4 more
europepmc   +1 more source

A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties

Aging Cell, EarlyView.
This study aimed to find safe senolytic drugs that selectively eliminate senescent cells. Focusing on HSP90 inhibitors, we employed a virtual screening to identify novel, safer compounds (A). K5, a xanthinic candidate, effectively eliminated senescent cells in various cellular models (B), extended lifespan in flies, and reduced aging signs in mice (C).
Sandra Atlante, Luca Cis, Davide Pirolli, Michela Gottardi Zamperla, Veronica Barbi, Antonello Mai, Clemens Zwergel, Serena Marcozzi, Maria Elisa Giuliani, Giorgia Bigossi, Giovanni Lai, Fiorenza Orlando, Robertina Giacconi, Fabrizia Lattanzio, Giulia Matacchione, Chiara Giordani, Massimo Bracci, Fabiola Olivieri, Federico Boschi, Paola Tabarelli De Fatis, Giovanni Battista Ivaldi, Marco Malavolta, Antonella Farsetti, Maria Cristina De Rosa, Carlo Gaetano   +24 more
wiley   +1 more source

NAT2 Acetylation Status Predicts Hepatotoxicity During Antituberculosis Therapy: Cumulative Risk Analysis of a Multiethnic Cohort. [PDF]

Int J Mol Sci
Schiuma M, Dinegro S, Battini V, Torre A, Covizzi A, Civati A, Galimberti M, Mariani I, Mosini G, Carnovale C, Riva A, Gori A, Antinori S, Clementi E, Radice S, Cheli S.   +15 more
europepmc   +1 more source

Early Hepatotoxicity of Methotrexate in Rheumatoid Arthritis

, 1970
Mahmood Parvin, Mamun-Ur Rashid, ARM Saifuddin Ekram, Hosna Ara Begum   +3 more
openalex   +2 more sources

Amiodarone Hepatotoxicity [PDF]

Digestive Diseases, 1997
S A, Josephson, E R, Kessel
openaire   +2 more sources

Emergency department–initiated oral naltrexone for patients with moderate to severe alcohol use disorder: A pilot feasibility study

Academic Emergency Medicine, Volume 32, Issue 5, Page 488-497, May 2025.
Abstract Objectives Alcohol use disorder (AUD) is the most common substance use disorder in the United States. Despite availability of four FDA‐approved medications, fewer than 10% of patients are prescribed medication. This study aimed to evaluate the impact and feasibility of emergency department (ED)‐initiated oral naltrexone in patients with ...
Ethan Cowan, Clare O'Brien‐Lambert, Erick Eiting, Edward Bull, Jacqueline Ryder, Yvette Calderon, Edwin Salsitz   +6 more
wiley   +1 more source