Results 221 to 230 of about 137,616 (341)

The liver–gut microbiota axis modulates hepatotoxicity of tacrine in the rat

Hepatology, 2018
Lian Yee Yip, C. Aw, Sze Han Lee, Yi Shuen Hong, Han Chen Ku, Winston Xu, Jessalyn Mei Xuan Chan, E. J. Y. Cheong, Kern Rei Chng, A. Ng, N. Nagarajan, R. Mahendran, Yuan-Kun Lee, E. Browne, E. Chan   +14 more
semanticscholar   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Oncologists' preferences for frontline TKI treatment of Ph+ acute lymphoblastic leukemia: a discrete choice experiment. [PDF]

Future Oncol
Ashaye A, Ramachandran N, Quaife M, Wu Y, Gutiérrez-Vargas ÁA, Jiongco A, Kota V, Savani B, Thomas C.   +8 more
europepmc   +1 more source

Hepatotoxic Effects of Lithocholic Acid and Sulfolithocholic Acid in Rabbits

, 1980
Keizo Nakao, Hideto Ohhara, Toyohiko Taki, Tsuneo Wakabayashi, Toshiharu OHGOH   +4 more
openalex   +2 more sources

Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management

Medicinal Research Reviews, EarlyView.
ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh, Shubham Mahajan, Sadikalmahdi Abdella, Rehan Khan, Sanjay Garg   +4 more
wiley   +1 more source

Pharmacogenomic analysis of alarelin acetate-induced hepatotoxicity: a case report and literature review. [PDF]

Front Med (Lausanne)
Yuan F, Zhang P, Liu M, Li Y, Xu B, Li X.   +5 more
europepmc   +1 more source

Quercetin attenuates toosendanin-induced hepatotoxicity through inducing the Nrf2/GCL/GSH antioxidant signaling pathway

Acta Pharmacologica Sinica, 2018
Yao Jin, Zhen Huang, Li Li, Yang Yang, Changhong Wang, Zheng-Tao Wang, L. Ji   +6 more
semanticscholar   +1 more source

Tenosynovial Giant Cell Tumor Treatment Revolution: Vimseltinib's Edge Over Pexidartinib

Medicine Advances, EarlyView.
This paper compares vimseltinib and pexidartinib in treating TGCT, highlighting key differences in their efficacy and safety, with vimseltinib showing better tumor reduction. Vimseltinib is more selective for CSF1R, leading to fewer side effects and no liver toxicity, whereas pexidartinib carries a higher risk of hepatotoxicity.
Muhammad Affan Abid, Syed Azfar Hussain, Muhammad Ali Kamal   +2 more
wiley   +1 more source

Comprehensive Evaluation of Hepatotoxicity Following Radiation Therapy in Breast Cancer Patients. [PDF]

Cancers (Basel)
Song JY, Hong SW, Kang SW, Jang BS, Kim IA.   +4 more
europepmc   +1 more source