Results 241 to 250 of about 137,616 (341)

Structure‐Guided Identification and Evaluation of Epalrestat and Ranirestat‐Like Compounds Against Aldose Reductase: Therapeutic Management of Diabetic Neuropathy

ChemistryOpen, EarlyView.
Structure‐based virtual screening of PubChem compounds identifies two novel epalrestat and ranirestat‐like inhibitors with improved affinity and pharmacokinetic profiles targeting aldose reductase. Molecular docking, ADMET filtering, and 500‐ns molecular dynamics simulations confirm the stability and interaction specificity of the candidates ...
Mohd Shahnawaz Khan, Dharmendra Kumar Yadav, Moyad Shahwan, Anas Shamsi   +3 more
wiley   +1 more source

Essential Oil Profiles of Lippia turbinata (Verbenaceae) from Argentina: Insights from a Systematic Review and Meta‐Analysis

ChemistryOpen, EarlyView.
This study systematically reviews essential oil (EO) profiles of Lippia turbinata (Verbenaceae) populations from Argentina. A meta‐analysis reveals significant chemical variability and distinct chemotypes, primarily defined by limonene, carvone, β‐caryophyllene, and caryophyllene oxide.
Fernando Livio Corzo, Franco Emmanuel Calvo, Emilio Fernando Lizarraga, Guillermo Emilio Marcial, Maria Ines Mercado   +4 more
wiley   +1 more source

Insights on Regioselective Synthesis of Fused Thiazoles: Density Functional Theory Calculations, Local Reactivity Indices, and Molecular Electrostatic Potential Analysis

ChemistryOpen, EarlyView.
A regioselective synthesis of fused thiazoles was achieved via aza‐Michael cyclization of thiazolidinone derivatives with hydrazines or heteroaryl amines. Density functional theory, local reactivity indices, and molecular electrostatic potential mapping are used to explain selectivity.
Ghaferah H. Al‐Hazmi, Jehan Y. Al‐Humaidi, Sayed M. Riyadh, Mohamed S. M. Ahmed, Magdi E. A. Zaki, Awatif H. Alruwaili, Khaled A. Alanazi, Rajeh H. Almutairi, Sobhi M. Gomha   +8 more
wiley   +1 more source

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

A Self‐Assembling Peptide with Nanoparticle‐to‐Fibril Transformation Exhibits Multimodal Antimicrobial Activity through Membrane Disruption and Quorum‐Sensing Inhibition

Small, EarlyView.
A self‐assembling peptide that transforms from nanoparticles into bacterial‐entrapping nanofibrils and targets multi‐drug‐resistant pathogens through a dual mechanism. It disrupts bacterial membranes and strongly inhibits the quorum‐sensing system, a crucial factor in biofilm formation and virulence.
James Mwangi, Demeke Asmamaw, Min Yang, Dawit Adisu Tadese, Brenda B. Michira, Yi Wang, Sheng‐wen Zhou, Gan Wang, Ziyi Wang, Qiu‐Min Lu, Ren Lai   +10 more
wiley   +1 more source

An Integrated Method to Evaluate the Treatment Efficacy and Immunogenicity of B‐Cell Acute Lymphoblastic Leukemia Therapeutic Enzyme Formulations

Small Methods, EarlyView.
This work presents an integrated set of methods to evaluate the efficacy of asparaginase formulations against B‐cell Acute Lymphoblastic Leukemia (ALL) in mice, including the establishment of an ALL murine model, an amino acid depletion study using high‐performance liquid chromatography (HPLC), and comprehensive assessment of antibody production ...
Julien Santelli, Annie Y. Heble, Connor Endsley, Adam Woodward, Nazia Hafeez, Naomi Winick, Jacques Lux   +6 more
wiley   +1 more source

Editorial: Toxicity mechanisms, exposure, toxicokinetic and risk assessment aspects of metals, toxic for animals and humans, volume III. [PDF]

Front Pharmacol
Boye A, Zhu Y, Li X, Machado MM, El Demerdash FM, Yang X.   +5 more
europepmc   +1 more source

Immune Activation in Primary Sclerosing Cholangitis: A Systematic Review and Comparative Analysis With Inflammatory Bowel Diseases

United European Gastroenterology Journal, EarlyView.
ABSTRACT Background and Objectives Primary sclerosing cholangitis (PSC) is a chronic liver disease with aberrant immune dysregulation and bile duct fibrosis. It is often associated with inflammatory bowel disease (IBD), especially ulcerative colitis, raising questions about distinct immune activation in these conditions.
Md Moniruzzaman, Ayesha Shah, Thomas Fairlie, Simon Keely, Grace L. Burns, Nicholas Talley, Gerald Holtmann   +6 more
wiley   +1 more source

Impact of halogenation on scaffold toxicity assessed using HD-GEM machine learning model. [PDF]

Brief Bioinform
Boya BR, Lee JH, Choi JM, Lee J.
europepmc   +1 more source

Nanotechnology and cell death: Revolutionizing disease treatment with nanoparticle strategies

VIEW, EarlyView.
Traditional disease treatments often face issues such as poor drug targeting and significant side effects, with many complex diseases lacking effective therapies. Our research utilizes tiny nanomaterials to treat diseases by regulating natural cell death processes, improving the immune environment, etc., enabling drugs to act more precisely.
Yiwen Wan, Wangzheqi Zhang, Yan Liao, Chenglong Zhu, Xiaojing Guo, Zui Zou, Mi Li   +6 more
wiley   +1 more source