Results 241 to 250 of about 160,647 (335)

Integrated network pharmacology and molecular docking reveal multi-target hepatotoxic mechanisms of Xanthii fructus. [PDF]

Medicine (Baltimore)
Fu X, Xiong F, Lin X, Lin Z, Jiang X.
europepmc   +1 more source

Complications of transplantation [PDF]

, 1975
Putnam, CW, Starzl, TE
core  

Selenium nanoparticles effects of in reducing hepatotoxicity brought on by cisplatin [PDF]

Emad A. Salem, Yasser A. Attia, Neveen A. Salem, Ahmed M. Fathallah, Akaber T. Keshta   +4 more
openalex   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Orexin receptor 2 agonists: a pathophysiologic approach to narcolepsy type 1. [PDF]

Ann Med Surg (Lond)
Arif Z, Siddiqui E, Hujjat SFZ, Khan MS, Mauhmoud A.   +4 more
europepmc   +1 more source

Liver transplantation, 1980, with particular reference to cyclosporin-A. [PDF]

, 1981
Iwatsuki, S, Klintmalm, G, Koep, LJ, Porter, KA, Schröter, GP, Starzl, TE, Weil, R   +6 more
core  

Computational Evaluation of Statin Analogs Targeting HMG‐CoA Reductase for Coronary Artery Disease Treatment

ChemistryOpen, EarlyView.
Molecular dynamics analysis of novel statin analogs shows that binding induces superior stabilization of HMG‐CoA reductase. As shown by the solvent‐accessible surface area profile, ligand‐induced rigidity offers a new, effective strategy for drug design. Cardiovascular diseases remain a leading cause of global mortality.
Yoshua B. Mtulo, Geradius Deogratias, James E. Mgaya, Andrew S. Paluch, Lucas Paul   +4 more
wiley   +1 more source

Ginsenoside RG3 and cantharidin synergistically suppress the progression of hepatocellular carcinoma via targeting the PRMT1-SREBF1 axis-mediated lipid metabolism. [PDF]

J Transl Med
Wang Y, Yuan H, Yu Y, Gou X, Wang Z, Zhou Z, Wang Z, Yan W, Wang H, Yan J.   +9 more
europepmc   +1 more source

The Evolution of Pneumocystis jirovecii Pneumonia Prophylaxis for Pediatric Patients With Extracranial Solid Tumors: A Review of Historical Insights and Future Directions

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pneumocystis jirovecii pneumonia (PJP) remains a modern‐day complication for pediatric patients receiving treatment for extracranial solid tumors (ST), highlighting the need for reconsideration of our current approach toward PJP prophylaxis. This critical review aims to evaluate both universal and risk‐stratified approaches to PJP prophylaxis ...
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source

A tuberculosis outbreak in a renal transplant program [PDF]

, 1991
Darras, F, Edmond, MB, Hakala, T, Ho, M, Jensen, C, Jordan, M, Kusne, S, McCauley, J, Medvick, J, Pascoulle, W, Scantlebury, V, Shapiro, R, Simmons, RL, Starzl, TE, Sundberg, R   +14 more
core