Results 261 to 270 of about 201,064 (349)

Arsenite methyltransferase 3 is required for mitochondrial function and hepatic lipid metabolism

The FEBS Journal, EarlyView.
AS3MT is a protein that helps the body process arsenic, a naturally occurring toxin found in water and soil. We discovered it also helps cells make and use energy properly. Without AS3MT, cells' mitochondria do not work well, leading to fatty liver and reduced activity. Increasing AS3MT in liver cells restores energy and protects against arsenic damage,
Patrice Delaney, James Griffin, Nouf Khan, Balnur Ibrash, Matthew J. O'Connor, Tomas Venit, Elizabeth Mayela Ambrosio, Spiros A. Pergantis, Elke Ober, Piergiorgio Percipalle, Kirsten C. Sadler   +10 more
wiley   +1 more source

Hierarchical Mechanistic Modeling of Complex Toxicity Endpoints from Public Concentration-Response Data. [PDF]

Environ Sci Technol
Chung E, Russo DP, Aleksunes LM, Warner GR, Zhu H.   +4 more
europepmc   +1 more source

Bringing Gene Therapy Into Real World Clinical Practice

Haemophilia, EarlyView.
ABSTRACT Introduction Adeno‐associated virus (AAV)‐based gene therapy for haemophilia has shifted therapeutic paradigms by enabling hepatic gene transfer, restoring endogenous clotting factor expression, and reducing reliance on conventional prophylactic treatments. Two products, valoctocogene roxaparvovec (haemophilia A) and etranacogene dezaparvovec (
Wolfgang Miesbach, Pratima Chowdary, Margareth C. Ozelo   +2 more
wiley   +1 more source

Drug-induced liver injury in inflammatory bowel disease: Challenges in diagnosis and monitoring. [PDF]

World J Hepatol
Singh A, Bhardwaj A, Kaur H, Bawa A, Midha V, Sood A.   +5 more
europepmc   +1 more source

Exploring the Anti-Cervical Cancer Effect and Hepatotoxicity Risk of Gossypol Based on Untargeted Metabolomics and Network Toxicology. [PDF]

Pharmaceuticals (Basel)
Li J, Parhat P, Ma Y, Peng L, Li M.
europepmc   +1 more source

Integrated single-cell transcriptomics and proteomics elucidate the molecular mechanisms and detoxification strategy of rifampicin-induced hepatotoxicity. [PDF]

Int J Biol Sci
Chen J, Zhang Q, Huang J, He H, Bai Y, An Y, Hao M, Zhao W, Li W, Feng S, Yang S, Liao J, Wong YK, Dai L, Du Q, Luo P, Wang J.   +16 more
europepmc   +1 more source

AI-enhanced clinical trial-in-a-dish platform for improved DILI risk classification and mechanistic insights into hepatotoxicity. [PDF]

Front Toxicol
Cherradi S, Roux S, Bailleux C, Devic C, Debaigt C, Guerda K, Luciano S, Dalle M, Duong HT.   +8 more
europepmc   +1 more source

Analysis of 386 alternative medicinal products implicated in liver injury reveal clinically relevant associations with potentially hepatotoxic botanicals, pharmaceutical adulteration, heavy metal contamination, and undisclosed animal content. [PDF]

Front Gastroenterol (Lausanne)
Philips CA, Oommen TT, Theruvath AH, Sreemohan A, Baby A, Ahamed R, Tharakan A, Augustine P.   +7 more
europepmc   +1 more source

Severe and disseminated atypical mycobacteriosis of the skin under immunosuppression

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Veronika Zenderowski, Laura Schreieder, Mark Berneburg, Dennis Niebel, Sebastian Haferkamp, Sigrid Karrer, Konstantin Drexler   +6 more
wiley   +1 more source