Results 271 to 280 of about 201,064 (349)

Hepatotoxic Mechanisms of Polyethylene Terephthalate Microplastics Revealed by Network Toxicology, Molecular Docking, and In Vivo Validation. [PDF]

Int J Mol Sci
Tan X, Zhang M, Lu J, Shi S, Shi X, Hou Z.   +5 more
europepmc   +1 more source

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Molecular mechanism of heavy metals (Lead, Chromium, Arsenic, Mercury, Nickel and Cadmium) - induced hepatotoxicity - A review.

Chemosphere, 2021
Heavy metals pose a serious threat if they go beyond permissible limits in our bodies. Much heavy metal's viz. Lead, Chromium, Arsenic, Mercury, Nickel, and Cadmium pose a serious threat when they go beyond permissible limits and cause hepatotoxicity ...
K. Renu, Rituraj Chakraborty, Haritha Myakala, R. Koti, A. Famurewa, H. Madhyastha, B. Vellingiri, Alex George, Abilash Valsala Gopalakrishnan   +8 more
semanticscholar   +1 more source

Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids.

Science of the Total Environment, 2021
Microplastic particles (MP) has been detected in the environment widespread. Human beings are inevitably exposed to MP via multiple routines. However, the hazard identifications, as direct evidence of exposure and health risk, have not been fully ...
Wei Cheng, Xiaolan Li, Yue Zhou, Hengyi Yu, Yichun Xie, Huaqi Guo, Hui Wang, Yan Li, Yan Feng, Yan Wang   +9 more
semanticscholar   +1 more source

Acrylamide-Induced Hepatotoxicity Through Oxidative Stress: Mechanisms and Interventions

Antioxidants and Redox Signaling, 2022
Significance: Acrylamide (AA) widely exists in the environment. Studies have demonstrated that AA has neurotoxicity and potential carcinogenicity in humans, and genotoxicity and severe hepatotoxicity in animals.
Lu Zhang, Liuqing Yang, Yinghua Luo, Li Dong, Fang Chen   +4 more
semanticscholar   +1 more source

Hepatotoxicity From Immune Checkpoint Inhibitors: A Systematic Review and Management Recommendation

Hepatology, 2020
Immune checkpoint inhibitors (ICIs) are monoclonal antibodies targeting immune checkpoint molecules. ICIs are an immunotherapy for the treatment of many advanced malignancies.
T. Peeraphatdit, Jennifer Wang, Matthew A. Odenwald, Shaomin Hu, J. Hart, M. Charlton   +5 more
semanticscholar   +1 more source

Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity

Nature Communications, 2018
Small interfering RNAs (siRNAs) conjugated to a trivalent N-acetylgalactosamine (GalNAc) ligand are being evaluated in investigational clinical studies for a variety of indications.
Mark K Schlegel, Ivan Zlatev, Huilei Xu
exaly   +2 more sources

New molecular and biochemical insights of doxorubicin-induced hepatotoxicity.

Life Science, 2020
Chemotherapeutic antibiotic doxorubicin belongs to the anthracycline class, slaughters not only the cancer cells but also non-cancerous cells even in the non-targeted organs thereby resulting in the toxicity.
P. Prasanna, K. Renu, A. V. Gopalakrishnan   +2 more
semanticscholar   +1 more source

Visualization of ONOO- and Viscosity in Drug-Induced Hepatotoxicity with Different Fluorescence Signals by a Sensitive Fluorescent Probe.

Analytical Chemistry, 2020
Drug-induced liver injury (DILI) is considered gradually as a serious public health issue, and hepatotoxicity has been regarded as the main clinical problem caused by it. We suspected that both the intracellular viscosity and peroxynitrite (ONOO-) levels
Yingzhen Deng, Guoqiang Feng
semanticscholar   +1 more source