Results 281 to 290 of about 201,064 (349)
Redox Biology, 2016 Acetaminophen (APAP) hepatotoxicity is characterized by an extensive oxidative stress. However, its source, pathophysiological role and possible therapeutic potential if targeted, have been controversially described. Earlier studies argued for cytochrome
Kuo Du +2 more
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Phytomedicine, 2020
BACKGROUND Oxidative stress-triggered fatal hepatotoxicity is an essential pathogenic factor in acute liver failure (ALF). AIMS To investigate the protective effect of daphnetin (Daph) on tert-butyl hydroperoxide (t-BHP) and acetaminophen (APAP ...
Hongming Lv +6 more
semanticscholar +1 more source
BACKGROUND Oxidative stress-triggered fatal hepatotoxicity is an essential pathogenic factor in acute liver failure (ALF). AIMS To investigate the protective effect of daphnetin (Daph) on tert-butyl hydroperoxide (t-BHP) and acetaminophen (APAP ...
Hongming Lv +6 more
semanticscholar +1 more source
Glyphosate-induced lipid metabolism disorder contributes to hepatotoxicity in juvenile common carp.
Environmental Pollution, 2020Residues of glyphosate (GLY) are widely detected in aquatic systems, raising potential environmental threats and public health concerns, but the mechanism underlying GLY-induced hepatotoxicity in fish has not been fully elucidated yet.
Jingbo Liu +4 more
semanticscholar +1 more source
Environmental Pollution, 2020
Cadmium (Cd), a heavy metal contaminant, exists in humans and animals throughout life and closely associate with severe hepatotoxicity. Selenium (Se) has been recognized as an effective chemo-protectant of Cd, but the underlying mechanisms remain unclear.
Cong Zhang +5 more
semanticscholar +1 more source
Cadmium (Cd), a heavy metal contaminant, exists in humans and animals throughout life and closely associate with severe hepatotoxicity. Selenium (Se) has been recognized as an effective chemo-protectant of Cd, but the underlying mechanisms remain unclear.
Cong Zhang +5 more
semanticscholar +1 more source
Clinics in Liver Disease, 2003
Unlike the bulk of medications, described in this fascicle, that cause liver injury in humans, acetaminophen is a non-prescription drug that can be purchased in drug stores and supermarkets without a physician's involvement. Death or severe injury is far more likely to occur with its use than with all the other medications considered in this study ...
Matthew Q, Bromer, Martin, Black
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Unlike the bulk of medications, described in this fascicle, that cause liver injury in humans, acetaminophen is a non-prescription drug that can be purchased in drug stores and supermarkets without a physician's involvement. Death or severe injury is far more likely to occur with its use than with all the other medications considered in this study ...
Matthew Q, Bromer, Martin, Black
openaire +2 more sources
Life Science, 2020
AIM Vancomycin (VCM) is a glycopeptide antibiotic widely used to treat serious infections caused by methicillin-resistant Staphylococcus aureus and has been associated with some severe side effects such as hepatotoxicity and nephrotoxicity.
Sefa Kucukler +5 more
semanticscholar +1 more source
AIM Vancomycin (VCM) is a glycopeptide antibiotic widely used to treat serious infections caused by methicillin-resistant Staphylococcus aureus and has been associated with some severe side effects such as hepatotoxicity and nephrotoxicity.
Sefa Kucukler +5 more
semanticscholar +1 more source
Annals of Internal Medicine, 1990
The Food and Drug Administration has received 11 reports of cases (three fatal) in the United States in which hepatocellular damage was associated with labetalol. The temporal circumstances strongly implicate labetalol; the conditions of nine patients improved after cessation of labetalol therapy, and one patient had a recurrence after therapy was ...
J A, Clark, H J, Zimmerman, L A, Tanner
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The Food and Drug Administration has received 11 reports of cases (three fatal) in the United States in which hepatocellular damage was associated with labetalol. The temporal circumstances strongly implicate labetalol; the conditions of nine patients improved after cessation of labetalol therapy, and one patient had a recurrence after therapy was ...
J A, Clark, H J, Zimmerman, L A, Tanner
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Southern Medical Journal, 2000
We report a case of hepatotoxicity in a 2-month-old baby after a camphor-containing cold remedy was applied dermally. Liver function tests returned to normal after the application of the cold remedy was discontinued. Ingestion of camphor can cause severe liver and central nervous system injury, and neurotoxicity has been observed after exposure to ...
A, Uc, W P, Bishop, K D, Sanders
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We report a case of hepatotoxicity in a 2-month-old baby after a camphor-containing cold remedy was applied dermally. Liver function tests returned to normal after the application of the cold remedy was discontinued. Ingestion of camphor can cause severe liver and central nervous system injury, and neurotoxicity has been observed after exposure to ...
A, Uc, W P, Bishop, K D, Sanders
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Gastroenterology, 1980
This review of acetaminophen hepatotoxicity begins with a history of the drug and consideration of the scope of its current use. The molecular basis for hepatotoxicity is discussed and this serves as a background for delineation of its clinical manifestations and treatment.
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This review of acetaminophen hepatotoxicity begins with a history of the drug and consideration of the scope of its current use. The molecular basis for hepatotoxicity is discussed and this serves as a background for delineation of its clinical manifestations and treatment.
openaire +3 more sources
Clinics in Liver Disease, 2006
Drug-induced liver injury is a common but underdiagnosed cause of liver disease with an incidence that is rapidly increasing. The authors address some of the more controversial aspects in relation to drug-induced liver injury: recommendations on the use of anti-tuberculosis therapy in the presence of underlying cirrhosis, the role of periodic liver ...
Rahul A, Nathwani, Neil, Kaplowitz
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Drug-induced liver injury is a common but underdiagnosed cause of liver disease with an incidence that is rapidly increasing. The authors address some of the more controversial aspects in relation to drug-induced liver injury: recommendations on the use of anti-tuberculosis therapy in the presence of underlying cirrhosis, the role of periodic liver ...
Rahul A, Nathwani, Neil, Kaplowitz
openaire +2 more sources