Results 261 to 270 of about 137,616 (341)

Clinical and Genetic Associations in Cephalosporin‐Induced Liver Injury: Insights From the Drug‐Induced Liver Injury Network

Alimentary Pharmacology &Therapeutics, EarlyView.
Cephalosporin‐induced liver injury usually presents as a self‐limited, mixed, or cholestatic hepatitis without hypersensitivity features, typically developing 1 to 4 weeks after treatment. With cefazolin, it often occurs after a single parenteral dose. A strong genetic association has been found with HLA‐A*02:01, with more severe liver injury at onset.
Raj Vuppalanchi, Yi‐Ju Li, Don C. Rockey, Dina Halegoua‐DeMarzio, Robert J. Fontana, Herbert L. Bonkovsky, Christopher Koh, Joseph Odin, Huiman Barnhart, Jay H. Hoofnagle, Drug‐Induced Liver Injury Network (DILIN)   +10 more
wiley   +1 more source

Non‐Response to Obeticholic Acid Is Associated With Heightened Risks of Developing Clinical Events in Primary Biliary Cholangitis

Alimentary Pharmacology &Therapeutics, EarlyView.
In a multi‐centre study of obeticholic acid in primary biliary cholangitis, 45% discontinued the drug over 4 years, with 11% moving to combination therapy (fibrates). Of those continuing, response rates increased from 37% (1 year) to 55% (4 years). Non‐response at 12 months and cirrhosis were independent predictors of liver‐related events.
Nadir Abbas, Rachel Smith, Ellina Lytvyak, Miki Scaravaglio, Neil Halliday, Amal Almahroos, Nadia Eden, Diane Lloyd‐Madden, Sanchit Sharma, James Ferguson, Jessica K. Dyson, Douglas Thorburn, David Jones, Aldo J. Montano‐Loza, Marco Carbone, Pietro Invernizzi, George Mells, Emma L. Culver, Palak J. Trivedi   +18 more
wiley   +1 more source

Assessing the Impact of Metabolic Syndrome on Liver Outcomes in Methotrexate Users: A Retrospective Cohort Study. [PDF]

J Clin Med
Kilani Y, Mosquera DAG, Fennell K, Qureshi K.   +3 more
europepmc   +1 more source

Antimicrobial prescribing guidelines for horses in Australia

Australian Veterinary Journal, EarlyView.
The growing problem of antimicrobial resistance also affects equine veterinarians with increasing frequency. Antimicrobial stewardship and responsible prescribing are essential for a future in which effective antimicrobials are available, as it is unlikely that new antimicrobials will become available for use in horses.
L Hardefeldt, K Thomas, S Page, J Norris, G Browning, C El Hage, A Stewart, J Gilkerson, G Muscatello, D Verwilghen, G van Galen, J Bauquier, R Cuming, B Reynolds, C Whittaker, E Wilkes, J Clulow, C Burden, L Begg   +18 more
wiley   +1 more source

Toosendanin Induces Hepatotoxicity by Facilitating ALOX5-Mediated Lipid Peroxidation and Sensitizing Cells to Ferroptosis. [PDF]

Pharmaceuticals (Basel)
Ni J, Huang L, Tian Y, Zhao C, Zhou Z, Shen F, Huang Z.   +6 more
europepmc   +1 more source

Statement of Retraction: Prophylactic role of Enhydra fluctuans against arsenic-induced hepatotoxicity via antiapoptotic and antioxidant mechanisms. [PDF]

Redox Rep
europepmc   +1 more source

Protective Role of Key Micronutrients in Chemotherapy-Induced Organ Toxicity: A Comprehensive Review of Mechanistic Insights and Clinical Implications. [PDF]

Nutrients
Konstantinidis I, Tsokkou S, Gavriilaki E, Delis G, Papamitsou T.   +4 more
europepmc   +1 more source

Hepatotoxicity Induced by Adalimumab in Chronic Plaque Psoriasis Patient: A Case Report. [PDF]

Int Med Case Rep J
Algarzae NK, Alotaibi HM, Alajlan AH, AlSaleh MR, Alsalman AA.   +4 more
europepmc   +1 more source

Liposomal 188Rhenium Plus Macrophage Depletion Enhances Anti‐PD‐L1 Efficacy and B Cell Infiltration Against Lung Metastatic Cancer

Cancer Science, EarlyView.
This study demonstrates that combining liposomal Rhenium‐188 (Lipo‐Re188) with macrophage depletion and anti–PD‐L1 therapy enhances therapeutic efficacy against lung metastatic colon cancer. The triple therapy promotes B cell infiltration, restores T cell function, and suppresses MDSC, creating a tumor‐suppressive immune microenvironment.
Shin‐Yi Liu, Liang‐Ting Lin, Chih‐Hsien Chang, Yu‐Jen Chen   +3 more
wiley   +1 more source

Impact of Genetic Polymorphisms on the Efficacy and Safety of Isoniazid in Saudi Tuberculosis Patients. [PDF]

Int J Genomics
Ahmad MAAAS, Alkreathy HM, Ali A, Ahmed S, Makki H.   +4 more
europepmc   +1 more source