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Toxicity of hepatotoxins: new insights into mechanisms and therapy
Expert Opinion on Investigational Drugs, 1999Liver injury caused by hepatotoxins, such as carbon tetrachloride (CCl4), ethanol, and acetaminophen (APAP), is characterised by varying degrees of hepatocyte degeneration and cell death via either apoptosis or necrosis. The generation of reactive intermediate metabolites from the metabolism of hepatotoxins, and the occurrence of reactive oxygen ...
J, Wu, A, Danielsson, M A, Zern
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Disposition of the hepatotoxin α-naphthylisothiocyanate (ANIT) in the rat
Toxicology and Applied Pharmacology, 1970Abstract The disposition of ANIT was investigated in the rat by examining quantitatively the tissue, organ, and subcellular distribution as well as the excretion pattern, of 14C at selected times after ANIT-14C administration. Approximately 70% of the radioactive material was absorbed from the gastrointestinal tract within 24 hr and was found widely ...
F, Capizzo, R J, Roberts
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[Resistance of regenerating liver to hepatotoxins].
Biulleten' eksperimental'noi biologii i meditsiny, 1976Treatment of mice with CCl4 and paracetamol induced massive centrilobular necroses. Preliminary induction of hepatocyte proliferation by partial hepatectomy significantly weakened or completely eliminated the toxic action on the liver depending on the time passed after the operation.
I V, Uryvaeva, V M, Faktor
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Medical surveillance for workplace hepatotoxins.
Occupational medicine (Philadelphia, Pa.), 1990In contrast to clinical practice, the objective of medical surveillance in a workplace population with potential exposure to hepatotoxins is to detect people with occupation-associated liver dysfunction who either have or are at risk for developing clinical disease.
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