Results 231 to 240 of about 4,105 (286)

Case Report: Dual toxicity of voriconazole in a CYP2C19 poor metabolizer: a case analysis of life-threatening neutropenia and hepatocellular injury. [PDF]

Front Pharmacol
Liu KK, Gong WJ.
europepmc   +1 more source

Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications

Portal Hypertension &Cirrhosis, EarlyView.
This review synthesizes the epigenetic mechanisms—DNA methylation, histone modifications, and non‐coding RNAs—that drive hepatic stellate cell activation and the progression of liver fibrosis. It further evaluates emerging therapeutic strategies targeting these epigenetic regulators, including DNA methyltransferase and histone deacetylase inhibitors ...
Maryam Jadid Tavaf, Mahboobeh Ebrahimi Varkiani, Saeid Abroun, Pedram Asadi‐Sarabi, Shukoofeh Torabi, Elham Rismani, Mohammad Majd Hammour, Andreas K. Nüssler, Massoud Vosough   +8 more
wiley   +1 more source

Can disulfiram modulate liver injury in CCl4-induced fibrosis in rats? [PDF]

Gastroenterol Hepatol Bed Bench
Rostami A, Golchoobian R, Esmaeili Z, Asghari MH, Hafezi N, Babazadeh Z.   +5 more
europepmc   +1 more source

Radiotherapy and Immunotherapy In Hepatocellular Carcinoma: Priming the Tumor Immune Microenvironment From Bench To Bedside

Precision Radiation Oncology, EarlyView.
The dual immunomodulatory network of radiotherapy in hepatocellular carcinoma. Radiotherapy initiates its effects by inducing immunogenic cell death and DNA double‐strand breaks. Immune Activation: Cytosolic DNA from damaged cells activates the cGAS‐STING pathway, triggering IRF3/NF‐κB‐mediated type I interferon production. This enhances dendritic cell
Zhigang Fu, Yang Zhang, Zuomin Wang, Zongjuan Li, Shisuo Du   +4 more
wiley   +1 more source

Antioxidant Therapy Reverses Hepatotoxicity Induced by Microcystin-LR in a Cellular Model of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). [PDF]

J Xenobiot
Lad A, Kindle J, Hegde P, Kleer GG, Kleinhenz AL, Birbeck JA, Westrick J, Peraino NJ, Hinds TD, Purandare N, Fribley AM, Haller ST, Kennedy DJ.   +12 more
europepmc   +1 more source

Delayed drug-induced liver injury (DILI) and flare of chronic plaque psoriasis secondary to lisinopril use. [PDF]

BMJ Case Rep
Jarman GL, Webb GJ.
europepmc   +1 more source

Delayed-Onset Hepatocellular Liver Injury Associated With Nitrofurantoin and Herbal Supplement Use: A Case Report With Multiple Potential Exposures. [PDF]

Case Rep Gastrointest Med
Mendoza E, Pustake M, Annabi J, Torres J, Mendez J, Kattamuri L, Williams B, Deoker A.   +7 more
europepmc   +1 more source

Severe Elevated Bile Acids in Early Pregnancy. [PDF]

ACG Case Rep J
Fass L, Sibbald C, Bailey E, Zhang W, Lucey M.   +4 more
europepmc   +1 more source

Global warming and hepatotoxin production by cyanobacteria: What can we learn from experiments?

Water Research, 2012
Global temperature is expected to rise throughout this century, and blooms of cyanobacteria in lakes and estuaries are predicted to increase with the current level of global warming.
Elena Gorokhova, Francisca Fernandez-Piñas, Francisca F del Campo   +2 more
exaly   +2 more sources

Hepatotoxin microcystin-LR extraction optimization [PDF]

Journal of the Brazilian Chemical Society, 2009
Several cyanobacterial genera produce toxic secondary metabolites, the most well-known of which are the hepatotoxic microcystins (MCYSTs). Microcystin analyses in drinking water are a requirement of the Health Ministry (Regulation 518/2004) in Brazil ...
Estela Stenico, Luiz Alberto Beraldo Moraes, Shishido Tk   +2 more
exaly   +2 more sources