Results 201 to 210 of about 4,021 (283)

Biomimetic MCC950‐loaded cerium‐layered double hydroxide nanoparticles for targeted treatment of Type 1 diabetes in streptozotocin‐induced mice

British Journal of Pharmacology, EarlyView.
The CLMBM nanoparticle (NP) system demonstrates strong and targeted anti‐ROS, antiapoptotic and anti‐inflammatory properties within the pancreas, thereby inhibiting the onset and progression of type 1 diabetes. Background and Purpose The destruction of β‐cells in type 1 diabetes is driven by signalling cascades that ultimately lead to cell apoptosis ...
Huiwen Pang, Zhuo Chen, Youzhi Wu, Thanh‐Truc Nguyen, Jingjing Wang, David M. Klyne, Zhi Ping Xu, Chen Chen, Alan Rowan, Felicity Y. Han   +9 more
wiley   +1 more source

Editorial: Acute liver injury and repair: cellular and molecular mechanisms. [PDF]

Front Cell Dev Biol
Lin X, Shi S, Chen L, Gao P, Yang L.
europepmc   +1 more source

Assessing Correlation of Quantitative Technetium‐99m Sestamibi Uptake in Thyroid Scintigraphy With Treatment Duration in Amiodarone‐Induced Thyrotoxicosis

Journal of Medical Imaging and Radiation Oncology, EarlyView.
Ray Wang, Nathan Better, Dinesh Sivaratnam, James Westcott, Simon Forehan, David A. Pattison, Spiros Fourlanos   +6 more
wiley   +1 more source

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

Antiseizure Treatments and Liver Injury: Expect (and Prevent) the Unexpected. [PDF]

Epilepsy Curr
Bunch M, Klocke S, Woodrich N, Barritt AS, Eyal S.   +4 more
europepmc   +1 more source

Afatinib Versus Osimertinib for Non‐Small Cell Lung Cancer With Uncommon EGFR Mutations: Real‐World Outcomes

Cancer Science, EarlyView.
Afatinib and osimertinib showed broadly comparable survival outcomes as first‐line therapy for NSCLC with uncommon EGFR mutations. Treatment may be individualized by mutation subtype, while adding immune checkpoint inhibition to platinum doublet after EGFR‐TKI showed no clear benefit.
Yutaro Nagano, Hiroshi Yokouchi, Ryota Saito, Osamu Honjo, Toshiyuki Sumi, Takayuki Kaburagi, Kenichiro Ito, Yasuyuki Ikezawa, Keiki Yokoo, Hajime Kikuchi, Sayaka Kudo, Masami Yamazoe, Ryota Shigaki, Keita Tagami, Toshiyuki Tenma, Tatsuru Ishikawa, Mamoru Takahashi, Takaaki Sasaki, Hajime Asahina, Shiro Hinotsu, Hirofumi Chiba, Satoshi Oizumi   +21 more
wiley   +1 more source

Kratom Consumption Associated With Herb-Induced Liver Injury and a Pharmacokinetic Interaction: A Case Report. [PDF]

Cureus
Gnanasegaram S, Stanciu CN.
europepmc   +1 more source

A Proposed Clinical Diagnostic Framework for Short Telomere Syndrome

Clinical Genetics, EarlyView.
We propose a phenotype‐based diagnostic framework for short telomere syndrome that integrates age‐adjusted telomere length, phenotypic manifestations, and genetic findings, where available. The framework is intended to guide clinical evaluation, longitudinal surveillance, and individualized management while acknowledging limitations in current telomere
Andrew Courtwright, Richard A. King, Jennie Vagher, Cate T. Levy, Juan Gallegos F. Orozco, Luis FZ Batista, Afaf Osman, Srinivas Tantavahi, Mary Beth Scholand   +8 more
wiley   +1 more source

Lactate‐Primed NETosis Modulates Hepatic Regeneration During Acute Liver Failure via the TLR9/KLF15/AJUBA Axis

Cell Proliferation, EarlyView.
This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo, Xiaoya Zhang, Danmei Zhang, Chunxia Shi, Luwen Wang, Zuojiong Gong   +5 more
wiley   +1 more source

Systematic analysis of hepatotoxicity: combining literature mining and AI language models. [PDF]

Front Artif Intell
Bauer C, Duc Dang LT, van den Beucken T, Schuchhardt J, Herwig R.   +4 more
europepmc   +1 more source