Alimentary Pharmacology &Therapeutics, EarlyView.We conducted a nationwide, multicenter cohort study using a target trial emulation framework to compare baclofen and acamprosate in patients with compensated alcohol‐associated cirrhosis. After matching, baclofen initiation was associated with a higher 1‐year risk of major adverse liver outcomes, driven primarily by hepatic encephalopathy, particularly
Yee Hui Yeo +13 more
wiley +1 more source
Intestinal Inflammation, Dysfunction of Intestinal Digestion, and Disorder in the Intestinal Microbiota and Their Metabolites Caused by Oral <i>Microcystis</i> Exposure in Common Carp (<i>Cyprinus carpio</i>). [PDF]
Biology (Basel)Lou M, Jing C, Liu X, Feng Y, Li X.
europepmc +1 more source
A Chemical and Ethnopharmacological Study on Phyllanthus emblica L. (Euphorbiaceae) [PDF]
, 1999 Summanen, Jari Olavi
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Affinity Proteomics‐Based Non‐Invasive Detection of Clinically Significant Liver Disease
Alimentary Pharmacology &Therapeutics, EarlyView.Using UK Biobank proteomic data, we identified a five‐protein score reflecting hepatic stellate cell activation and hepatocellular injury that predicts major adverse liver outcomes and clinically significant fibrosis, with consistent performance validated in two independent cohorts (patients with HIV and alpha1‐antitrypsin deficiency).
Sriram Balasubramani +14 more
wiley +1 more source
Mouse Models for the Study of Liver Fibrosis Regression In Vivo and Ex Vivo. [PDF]
J Clin Transl HepatolSchönke M, Rensen PCN.
europepmc +1 more source
British Journal of Haematology, EarlyView.Summary Mature T‐cell lymphomas comprise a heterogeneous group of aggressive non‐Hodgkin lymphomas with limited therapeutic options in the relapsed or refractory setting. Among them, anaplastic lymphoma kinase (ALK)‐positive anaplastic large cell lymphoma (ALCL) represents a biologically distinct subtype driven by constitutive activation of ALK fusion ...
Santino Caserta +13 more
wiley +1 more source
Exposure Type and Duration Determine Ecotoxicological Effects of Cyanobacteria Anatoxins on the Benthic Amphipod <i>Hyalella azteca</i>. [PDF]
Toxins (Basel)Yogeshwar IK +3 more
europepmc +1 more source
Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges
British Journal of Pharmacology, EarlyView.This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu +6 more
wiley +1 more source
The Corrective Role of Melatonin in Synergism of Dark Deprivation and CCl4 Intoxication in the Pathogenesis of Liver Damage a in Rats. [PDF]
Curr Issues Mol BiolGrabeklis SA +6 more
europepmc +1 more source