Results 221 to 230 of about 4,021 (283)

Dual IRE1 targets: Determinants of the cell fate?

The FEBS Journal, EarlyView.
IRE1 is an ER stress sensor that restores protein homeostasis through two signaling activities: XBP1s, which upregulates its target gene expression or RIDD which downregulates its target transcripts. We recently identified Dual IRE1 Targets (DIT) which are modulated by both XBP1s and RIDD activities.
Eva Billat, Léane Legrand, Tony Avril, Elodie Lafont   +3 more
wiley   +1 more source

Intestinal Inflammation, Dysfunction of Intestinal Digestion, and Disorder in the Intestinal Microbiota and Their Metabolites Caused by Oral <i>Microcystis</i> Exposure in Common Carp (<i>Cyprinus carpio</i>). [PDF]

Biology (Basel)
Lou M, Jing C, Liu X, Feng Y, Li X.
europepmc   +1 more source

Bringing Gene Therapy Into Real World Clinical Practice

Haemophilia, EarlyView.
ABSTRACT Introduction Adeno‐associated virus (AAV)‐based gene therapy for haemophilia has shifted therapeutic paradigms by enabling hepatic gene transfer, restoring endogenous clotting factor expression, and reducing reliance on conventional prophylactic treatments. Two products, valoctocogene roxaparvovec (haemophilia A) and etranacogene dezaparvovec (
Wolfgang Miesbach, Pratima Chowdary, Margareth C. Ozelo   +2 more
wiley   +1 more source

The Corrective Role of Melatonin in Synergism of Dark Deprivation and CCl₄ Intoxication in the Pathogenesis of Liver Damage a in Rats. [PDF]

Curr Issues Mol Biol
Grabeklis SA, Mikhaleva LM, Dygai AM, Vandysheva RA, Anurkina AI, Kozlova MA, Areshidze DA.   +6 more
europepmc   +1 more source

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

Aristolochic Acid and Hepatocellular Carcinoma: A Critical Review of Genotoxic and Inflammatory Mechanisms. [PDF]

Int J Mol Sci
Wang Y, Zhang Y, Ren T, Yuan L, Geng X.
europepmc   +1 more source

Erythropoietic protoporphyrias: Pathogenesis, diagnosis and management. [PDF]

Liver Int
Minder AE, Kluijver LG, Barman-Aksözen J, Minder EI, Langendonk JG.   +4 more
europepmc   +1 more source

Hydroculture Cultivation of Strawberries as Potential Reference Material for Microcystin Analysis: Approaches and Pitfalls. [PDF]

Toxins (Basel)
Van Hassel WHR, Guillaume B, Masquelier J.   +2 more
europepmc   +1 more source

Should the theory of methotrexate-induced liver toxicity be abandoned? [PDF]

World J Hepatol
Al-Hammada Y, Sharba S, Al-Dury S.
europepmc   +1 more source

"Algal-dromes": a novel conceptual approach to illness in humans exposed to harmful algal bloom toxins. [PDF]

Front Toxicol
Johnson B, Richlen M, Lai J, Twiner MJ.
europepmc   +1 more source