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Hepcidin and Iron in Health and Disease [PDF]

open access: yesAnnual Review of Medicine, 2023
Hepcidin, the iron-regulatory hormone, determines plasma iron concentrations and total body iron content. Hepcidin, secreted by hepatocytes, functions by controlling the activity of the cellular iron exporter ferroportin, which delivers iron to plasma ...
Tomas Ganz, Elizabeta Nemeth
exaly   +2 more sources

Iron disorders and hepcidin

Clinica Chimica Acta, 2021
Iron is an essential element due to its role in a wide variety of physiological processes. Iron homeostasis is crucial to prevent iron overload disorders as well as iron deficiency anemia. The liver synthesized peptide hormone hepcidin is a master regulator of systemic iron metabolism.
Shilpa, Rana, Nirmal, Prabhakar
openaire   +2 more sources

Hepcidin and anaemia

Blood Reviews, 2004
The anaemia of chronic disease (ACD) is a common haematologic syndrome characterized by hypoferraemia with adequate reticuloendothelial iron stores. Frequently, serum ferritin concentration in these patients is elevated. The pathogenesis of ACD involves abnormalities in red cell survival, the erythropoietic response to anaemia, and in iron metabolism ...
openaire   +2 more sources

Hepcidin in Iron Metabolism

Current Protein & Peptide Science, 2005
Hepcidin, which has been recently identified both by biochemical and genomic approaches, is a 25 amino acid polypeptide synthesized mainly by hepatocytes and secreted into the plasma. Besides its potential activity in antimicrobial defense, hepcidin plays a major role in iron metabolism. It controls two key steps of iron bioavailability, likely through
Olivier, Loréal   +7 more
openaire   +2 more sources

Hepcidin and IL-1β

2019
Hepcidin expression is determined through transcriptional regulation by systemic iron status. However, acute or chronic inflammation also increases the expression of hepcidin, which is associated with the dysregulation of iron metabolism in pathological conditions.
Yohei, Kanamori   +5 more
openaire   +2 more sources

Hepcidin: immunoanalytic characteristics

Annales de biologie clinique, 2018
Hepcidin has progressively become essential in clinical practice for the diagnosis and follow-up of a large spectrum of diseases. Anyway, its own biochemical and structural characteristics have complicated and delayed the acquisition of a standardized quantifying tool of the peptide.
Wolff, Fleur   +9 more
openaire   +2 more sources

Role of Ferroptosis in ALD: Focusing on Hepcidin and Besides Hepcidin

Current Medicinal Chemistry
Ascending incidence and poor outcomes make Alcoholic Liver Disease (ALD) a considerable public health concern. This review concluded the iron metabolism under physiology conditions and alcohol disturbance (leading to ferroptosis in ALD) and summarized the novel treatment, diagnosis, and prognosis of ferroptosis
Leijie Chen   +4 more
openaire   +2 more sources

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