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Comparative analysis of Xenopus tropicalis hepcidin I and hepcidin II genes
Gene, 2008Hepcidin is an antimicrobial peptide and an iron-regulatory hormone that is conserved in fish, amphibians, and mammalians. Here we report the genomic and biochemical characterization of two amphibian hepcidins (tHEP1 and tHEP2) from the Western clawed frog (Xenopus tropicalis). Similar to fish and mammalian hepcidins, both tHEP1 and tHEP2 genes contain
Xueyou, Hu +7 more
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Current Opinion in Hematology, 2004
Hepcidin is a recently discovered hepatic peptide that regulates intestinal iron absorption as well as maternal-fetal iron transport across the placenta. It probably also affects the release of iron from hepatic stores and from macrophages involved in the recycling of iron from hemoglobin.
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Hepcidin is a recently discovered hepatic peptide that regulates intestinal iron absorption as well as maternal-fetal iron transport across the placenta. It probably also affects the release of iron from hepatic stores and from macrophages involved in the recycling of iron from hemoglobin.
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Pursuing Orally Bioavailable Hepcidin Analogues via Cyclic N-Methylated Mini-Hepcidins
Biomedicines, 2021Eileen Fung +2 more
exaly
The role of the iron homeostasis mechanism is summarized in this article. Iron plays an important role in managing bodily functions such as growth and development, and makes haemoglobin, and some hormones. Hepcidin acts differently in different conditions; if the body needs more oxygen, the hepcidin levels decrease allowing iron to enter the plasma and
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2015
This chapter focuses on the signaling pathways involved in the synthesis of hepcidin, the iron hormone, and discusses the pathophysiological consequences of genetic and nongenetic disruption of its regulation. Hepcidin acts as the principal physiological inhibitor of iron flux into the bloodstream by inhibiting its receptor, the iron exporter ...
Vecchi C., Pietrangelo A.
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This chapter focuses on the signaling pathways involved in the synthesis of hepcidin, the iron hormone, and discusses the pathophysiological consequences of genetic and nongenetic disruption of its regulation. Hepcidin acts as the principal physiological inhibitor of iron flux into the bloodstream by inhibiting its receptor, the iron exporter ...
Vecchi C., Pietrangelo A.
openaire +1 more source