Comparison of tumors with HER2 overexpression versus HER2 amplification in HER2-positive breast cancer patients [PDF]
BMC Cancer, 2022 Abstract Background Human epidermal growth factor receptor 2 (HER2)-positive tumors are defined by protein overexpression (3+) or gene amplification using immunohistochemistry (IHC) or fluorescence in situ hybridization (FISH), respectively.
Yoshiya Horimoto +5 more
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Cancer Research, Statistics, and Treatment, 2020 Introduction: Majority of the patients in low-to-middle income countries (LMICs) have no access to adjuvant trastuzumab due to financial constraints. Short-course (9 weeks) schedule of trastuzumab is a feasible alternative in this setting.
Avaronnan Manuprasad +5 more
doaj +1 more source
GLUCOSE LEVELS OF PLEURAL EFFUSION FLUID AND HER2 STATUS IN PLEURAL-METASTATIC BREAST CANCER
Majalah Biomorfologi, 2023 Highlights • Patients with breast cancer who have distant metastases are frequently impacted by pleural effusion. • HER2 status was found to be substantially correlated with glucose levels in pleural effusion fluid.
Muhammad Dhanny Irawan +2 more
doaj +1 more source
Assessment of correlation between Trastuzumab resistance and miR-885-3p relative expression in the BT-474 Human Breast Cancer Cell Line [PDF]
Journal of Epigenetics, 2019 Trastuzumab has been applied widely in the treatment of breast cancer. The majority of initial responders display disease progression again within one year.
Zohreh Rezaei, Kazem Dastjerdi
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Cannabinoid receptor CB2 drives HER2 pro-oncogenic signaling in breast cancer [PDF]
, 2015 Pharmacological activation of cannabinoid receptors elicits antitumoral responses in different models of cancer. However, the biological role of these receptors in tumor physio-pathology is still unknown.
Alkatout, Ibrahim +31 more
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Calmodulin binds HER2 and modulates HER2 signaling
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2011 Human epidermal growth factor receptor 2 (HER2), a member of the ErbB family of receptor tyrosine kinases, has defined roles in neoplastic transformation and tumor progression. Overexpression of HER2 is an adverse prognostic factor in several human neoplasms and, particularly in breast cancer, correlates strongly with a decrease in overall patient ...
White, Colin D. +2 more
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MiR-18a-5p attenuates HER2-positive breast cancer development by regulating PI3K/AKT pathway
Cancer Biology & Therapy, 2023 Objective: Human epidermal growth factor receptor 2 positive (HER2+) breast cancer (BC) is associated with poor prognosis. This study aimed to elucidate the role of miR−18a−5p in regulation of HER2+-BC progression along with its mechanism of action ...
Yongjun Liu, Hua Yang
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Afatinib use in recurrent epithelial ovarian carcinoma. [PDF]
, 2019 •Genomic tumor testing is an important tool in guiding treatment for gynecologic malignancies.•Targetable mutations may lead to new therapies in gynecologic cancer treatment.•Her2/neu mutations in serous ovarian carcinomas can be targeted with ERBB2 ...
Alvarez, Edwin A +3 more
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Pattern of HER2 Overexpression in Urinary Bladder Carcinomas in Kano, Nigeria
The Annals of African Surgery, 2023 Background: The worldwide distribution of bladder cancer varies, conforming to differences in environmental and genetic risk factors. HER2 neu is overexpressed in many human cancers, including urinary bladder carcinomas.
Muhammad Sanusi Haruna +2 more
doaj +1 more source
Topoisomerase expression and amplification in solid tumours: Analysis of 24,262 patients. [PDF]
, 2017 BackgroundTopoisomerase I (TOPO1) and topoisomerase IIα (TOP2A) are specific targets of multiple chemotherapy drugs. Increased expression of TOPO1 protein and amplification of the TOP2A gene have been associated with treatment response in colorectal and ...
Arguello, David +4 more
core +1 more source