Results 91 to 100 of about 25,109 (253)

HER3 overexpression: a predictive marker for poor prognosis in advanced ALK-positive non-small cell lung cancer treated with ALK inhibitors

Translational Lung Cancer Research
Background Anaplastic lymphoma kinase (ALK)-targeted tyrosine kinase inhibitors (TKIs) improve patient survival; however, some patients develop ALK-TKI resistance with unidentified mechanisms.
Meejeong Kim, H. Ju, Ji-young Song, Josephina Sampson, Richard Bayliss, Jene Choi   +5 more
semanticscholar   +1 more source

A small molecule inhibitor of HER3: a proof-of-concept study [PDF]

, 2020
Audrey Colomba, Martina Fitzek, Roger George, Gregory Weitsman, Selene K. Roberts, Laura C. Zanetti-Domingues, Michael Hirsch, Daniel J. Rolfe, Shahid Mehmood, Andrew Madin, Jeroen Claus, Svend Kjær, Ambrosius P. Snijders, Tony Ng, Marisa L. Martin-Fernandez, David M. Smith, Peter J. Parker   +16 more
openalex   +1 more source

An Overview of Liquid Chromatography–Mass Spectrometry (LC–MS) Methods for the Quantification of Antibody‐Drug Conjugates

Biomedical Chromatography, Volume 40, Issue 2, February 2026.
ABSTRACT Antibody‐drug conjugates (ADCs) are innovative drugs composed of cytotoxic molecules (payload) linked to antibodies, that selectively target and kill cancer cells upon internalization. In vivo, ADCs exist as intact molecules, naked antibodies, or released, unconjugated (linker‐)payload.
Pauline L. M. Buitelaar, Hilde Rosing, Jos H. Beijnen, Neeltje Steeghs, Alwin D. R. Huitema   +4 more
wiley   +1 more source

Data Supplement from Functional Genetic Approach Identifies MET, HER3, IGF1R, INSR Pathways as Determinants of Lapatinib Unresponsiveness in HER2-Positive Gastric Cancer

, 2023
Zhe Zhang, Jiping Wang, Dongmei Ji, Chenchen Wang, Rujiao Liu, Zheng Wu, Lian Liu, Dan Zhu, Jinjia Chang, Ruixuan Geng, Lei Xiong, Qiangyi Fang, Jin Li   +12 more
openalex   +2 more sources

320 Phase IIa study of alpha-DC1 vaccine against HER2/HER3, chemokine modulation regimen and pembrolizumab in patients with asymptomatic brain metastasis from triple negative or HER2+ breast cancer [PDF]

, 2020
Shipra Gandhi, Peter Forsyth, Mateusz Opyrchal, Kamran A. Ahmed, Hung T. Khong, Kristopher Attwood, Ellis Levine, Tracey L. O’Connor, Amy Early, Robert A. Fenstermaker, Dheerendra Prasad, Kazuaki Takabe, Brian J. Czerniecki, Paweł Kaliński   +13 more
openalex   +1 more source

Potential Targets and Biomarkers of Radionuclide Therapy in Breast Cancer

Cancer Innovation, Volume 5, Issue 1, February 2026.
Potential biomarkers for the development of targeted radionuclide therapy that can be employed in the treatment of breast cancer have been summarised in the review. They include receptor markers of ER, PR and HER2, as well as other markers of Trop2, PD‐1, EGFR, GRPR and PSMA.
Yujing Tan, Cheng Zeng, Jiani Wang, Fei Ma   +3 more
wiley   +1 more source

Incidence Rate of Otitis Externa Episodes in Atopic Dogs Is Reduced by a Therapeutic Diet in a 6‐Month Randomised, Blinded, Controlled, Clinical Trial

Veterinary Dermatology, Volume 37, Issue 1, Page 89-102, February 2026.
ABSTRACT Background Recurrent otitis externa (OE) episodes commonly affect dogs with canine atopic dermatitis (cAD) despite ongoing cAD treatment. Objective To determine if a therapeutic diet with active ingredients targeting the skin barrier and allergy pathways reduces the incidence rate of OE.
Adrian Watson, Jeremy Laxalde, Franco Martini, Nina Fischer, Elisa Maina, Claude Favrot   +5 more
wiley   +1 more source

Influence of Molecular Design on the Targeting Properties of ABD-Fused Mono- and Bi-Valent Anti-HER3 Affibody Therapeutic Constructs

Cells, 2018
Overexpression of human epidermal growth factor receptor type 3 (HER3) is associated with tumour cell resistance to HER-targeted therapies. Monoclonal antibodies (mAbs) targeting HER3 are currently being investigated for treatment of various types of ...
Mohamed Altai, Charles Dahlsson Leitao, Sara S. Rinne, Anzhelika Vorobyeva, Christina Atterby, Stefan Ståhl, Vladimir Tolmachev, John Löfblom, Anna Orlova   +8 more
doaj   +1 more source

Development of a Four‐Language Questionnaire to Investigate Environmental Risk Factors for the Development of Canine Atopic Dermatitis and to Monitor Disease Course and Progression

Veterinary Dermatology, Volume 37, Issue 1, Page 34-44, February 2026.
Background: The chronic and multifactorial character of canine atopic dermatitis (cAD) often leads to poor disease control and treatment dissatisfaction. Environmental factors are likely to contribute to the disease development and may play a more important role than assumed previously.
Patricia Clara‐Maria Rhodius, Nina Fischer, Ana Rostaher, Franco Martini, Edwin Chapman, Sabrina Audergon, Stefan Hobi, Georg Lehner, Sylvie Wilhelm, Noëmi van Oordt, Claude Favrot, Malwina Kowalska   +11 more
wiley   +1 more source

Transcriptional landscape of DTP-DTEP transition reveals DUSP6 as a driver of HER2 inhibitor tolerance via Neuregulin/HER3 axis [PDF]

, 2023
Majid Momeny, Mari Tienhaara, Deepankar Chakroborty, Mukund Sharma, Roosa Varjus, Joni Merisaari, Artur Padzik, Andreas Vogt, Ilkka Paatero, Kari J. Kurppa, Klaus Elenius, Teemu D. Laajala, Jukka Westermarck   +12 more
openalex   +1 more source