Results 71 to 80 of about 25,109 (253)
Andrology, EarlyView.Abstract Couple infertility is a very ancient medical condition. One of the first descriptions of familial infertility/subfertility is contained in the first book of the Bible, Genesis, written in the 10th century BC and reporting tales from the oral tradition even occurred about 800 years earlier.
Manuela Simoni +2 more
wiley +1 more source
Cancer Science, EarlyView.Overexpression of ABC transporters, especially ABCG2 and ABCB1, mediates acquired resistance to T‐DXd in HER2‐positive cancers. Inhibition of these transporters restored T‐DXd efficacy, highlighting efflux‐mediated resistance as a potential therapeutic target. ABSTRACT Antibody–drug conjugates (ADCs) are emerging as a promising class of targeted cancer
Yuya Murase +23 more
wiley +1 more source
HER3-targeted therapy: the mechanism of drug resistance and the development of anticancer drugs
Cancer Drug ResistanceHuman epidermal growth factor receptor 3 (HER3), which is part of the HER family, is aberrantly expressed in various human cancers. Since HER3 only has weak tyrosine kinase activity, when HER3 ligand neuregulin 1 (NRG1) or neuregulin 2 (NRG2) appears ...
Huilan Zeng +3 more
semanticscholar +1 more source
HER kinase inhibition in patients with HER2- and HER3-mutant cancers
Nature, 2018 Somatic mutations of ERBB2 and ERBB3 (which encode HER2 and HER3, respectively) are found in a wide range of cancers. Preclinical modelling suggests that a subset of these mutations lead to constitutive HER2 activation, but most remain biologically ...
David M. Hyman +46 more
semanticscholar +1 more source
International Journal of Applied Linguistics, EarlyView.ABSTRACT Spurred by the advancement of educational technology, more language instruction has been offered in online environments. Consequently, teaching practices have had to adapt to digital platforms. Accordingly, teachers’ provision of synchronous written corrective feedback (SWCF) on digital texts has received increasing attention.
Sanghee Kang, YouJin Kim, Minkyung Kim
wiley +1 more source
Frontiers in Oncology, 2020 Triple Negative Breast Cancer (TNBC) is an aggressive form of Breast Cancer (BC). Numerous kinase inhibitors (KI) targeting different pathway nodes have shown limited benefit in the clinical setting.
Nicoleta Sinevici +6 more
doaj +1 more source
Cell Death and Disease, 2022 Over the past decade, immunotherapy delivered novel treatments for many cancer types. However, lung cancer still leads cancer mortality, and non-small-cell lung carcinoma patients with mutant EGFR cannot benefit from checkpoint inhibitors due to toxicity,
J. Vicencio +39 more
semanticscholar +1 more source
Japanese Women's Attitudes Toward Learning Languages Other Than English in the Era of Global English
International Journal of Applied Linguistics, EarlyView.ABSTRACT This study on female Japanese learners of the Korean language is situated in the centuries‐long anti‐Korean sentiments in Japan, the global popularity of the Korean Wave, particularly among women, and the essentialized image of socially marginalized young Japanese women who study English with romantic desires for Western men.
Yoko Kobayashi
wiley +1 more source
Understanding the biology of HER3 receptor as a therapeutic target in human cancer
Acta Pharmaceutica Sinica B, 2018 HER3 belongs to the human epidermal growth factor receptor (HER) family which also includes HER1/EGFR/erbB1, HER2/erbB2, and HER4/erbB4. As a unique member of the HER family, HER3 lacks or has little intrinsic tyrosine kinase activity.
Hui Lyu +4 more
doaj +1 more source
Veterinary Dermatology, EarlyView.Canine atopic dermatitis (cAD) is a chronic condition requiring life‐long management. Accurate diagnosis can be challenging, with no reliable diagnostic test. This study aimed to generate a simple diagnostic model for cAD. This model is a relevant prototype for an app‐based tool to support general practitioners in the diagnosis of cAD alongside ...
Xavier Langon +2 more
wiley +1 more source