Results 141 to 150 of about 317,082 (297)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Out of Nature: How a Concept Became a Political Power?
, 2019 info:eu-repo/semantics ...
Debaise, Didier
core
Strain-level analyses of public sequencing data to characterize <i>Escherichia coli</i> strain sharing between children and chickens in Mozambique. [PDF]
One HealthOlson N +13 more
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
This article attempts to demonstrate the nature of the impacts of prevailing Sufi teachings on the belief in the hereafter in the present era. Some aspects of prevailing Sufi teachings are negative, while others are positive.
Prof. Dr. Abdul Hameed Khan Abbasi +1 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The Nature of Questioning in the Hereafter According to the Qurʾān
Âhiret hayatına ilişkin yapılan tasvirler Kur’ân’da en yoğun şekilde işlenen konular arasında yer almaktadır. Bunun en temel sebebi, âhiret inancı ve hesap verme bilincini insanın zihin ve gönlüne yerleştirerek davranışlarının olumlu yönde değişimini ...
Kılıç, Hasan
core +1 more source
Engineering serine metabolism to enhance AOX1 promoter self-induction in formate dehydrogenase-deficient Komagataella phaffii. [PDF]
Microb Cell FactCozmar R, Berrios J, Fickers P.
europepmc +1 more source