Results 121 to 130 of about 317,082 (297)
¿Sin Dolores? La ética política de Maquiavelo y Weber en The Sweet Hereafter
Revista Enfoques, 2009 This article, on one hand, seeks to analyze the relationship between ethics and politics through Atom Egoyan's film, The Sweet Hereafter ; and on the other hand, it means to demonstrate that theoretical reflection on certain questions not only can and ...
Javier Franzé
doaj
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
The Time of Tragedy: Thinking the Contemporary with Cavell and Agamben
Allow me to begin this article by asking the reader to visualize a brief yet disturbing scene. Assuming that you are sitting down whilst reading this, I ask you to imagine, if you will, that about a dozen paces from your seat, you see a young couple – an
Rudrum, David
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Three Articulations of The Sweet Hereafter: The Auteur, the Novelist and the Co-authored Text
, 2014 The repetition of the title The Sweet Hereafter for novel (1991), film/DVD (1997/1998) and book chapter (2004) is suggestive of the slippages between them.
Gavin, Melissa J.
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
, 2013 In the course of reflecting on Tom Greggs' recent claim that Barth ‘did not reject universalism [...] only problematic elements associated with it’, Mark Koonz raises the fascinating question of Barth’s doctrinal position on universalism.
Koonz, Mark
core
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source