Results 101 to 110 of about 317,082 (297)

New Procedural Notices of the Czech Office for the Protection of Competition: Leniency, Settlement, and Alternative Problem Resolution [PDF]

open access: yesYearbook of Antitrust and Regulatory Studies, 2015
In connection with the 2012 amendment of the Czech Act on the Protection of Competition (hereafter, APC), reported in YARS last year1, the Czech Office for the Protection of Competition (hereafter, Office) issued three new procedural noticesin November ...
Petra Joanna Pipková, Ivo Šimeček
doaj  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Considering Life, Death, and the Hereafter in Tomb Monuments in Early Modern Rome

open access: yesIncontri: Rivista Europea di Studi Italiani
Review of: Jan L. de Jong, Tombs in Early Modern Rome (1400-1600). Monuments of Mourning, Memory and Meditation (Brill’s Studies on Art, Art History, and Intellectual History, vol. 65), Leiden, Brill, 2022.
Laura Overpelt
doaj   +1 more source

VOL. 2012, 5(6)The EMPiK and Merlin concentration prohibition: Would the European Commission reach a similar verdict?Case comment to the decision of the President of the Office for Competition and Consumer Protection of 3 February 2011 – Merlin.pl S.A. and NFI EMPiK Media & Fashion S.A (DKK-12/2011) [PDF]

open access: yesYearbook of Antitrust and Regulatory Studies, 2012
On 3 February 2011, the President of the Office of Competition and Consumer Protection (the Polish national competition agency, hereafter referred to as the UOKiK, after the Polish acronym), pursuant to Article 20(1) of the Act of 16 February 2007 on ...
Mateusz Radomyski
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Unsafe and unfair: a critique of the Safety, Rehabilitation Compensation Legislation Amendment Bill 2014 [PDF]

open access: yes, 2015
This report analyses the proposed Safety, Rehabilitation and Compensation Bill 2014 (Cth) (SRC Bill), and, for a number of key reasons, argues that the bill should be rejected.
Joanna Howe
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Episode 28 - The Sweet Hereafter (1997) (Guest: Seán Patrick Donlan)

open access: yes
This episode explores Atom Egoyan\u27s 1997 film, The Sweet Hereafter, which describes the impact of a tragic school bus accident that caused the death of 14 children on a small Canadian town.
Hafetz, Jonathan
core   +1 more source

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