Results 91 to 100 of about 344,460 (285)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The belief of the hereafter in İslam and the reincarnation
, 2010 Kur'an'da Ölüm Sonrası ve Reenkarnasyon konusunu değişik yonlerden ele almaya, Kur'an'a göre Reenkarnasyon varmıdır, varsa ne şekilde ve nasıldır sorusuna cevap bulmaya çalışılmıştır.The blief of hereafter (Ahiret) is one of the Islam&
Sharivkhan, Galimbek
core
Belief in the hereafter in the Nusayri sect
, 2022 Hz. Peygamber'in vefatının ardından mezhepsel oluşumlar ortaya çıkmıştır. Bunlar arasında yer bulan Nusayri mezhebi, Muhammed b. Nusayr en- Nemiri tarafından kurulan, Hamdan el- Hasibî tarafından sistematik hale getirilen Şiî Bâtıni bir fırka olarak
Seyit, Büşra Meryem
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The economic approach in Polish courts: permitted agency agreements or prohibited price fixing? Case comment to the judgment of the Appeal Court in Warsaw of 13 February 2007 – Roche and Hand-Prod (Ref. No. VI AcA 819/06) [PDF]
Yearbook of Antitrust and Regulatory Studies, 2008 By the decision of 29 June 2004 (no. RWA-18/2004), the President of the Polish Office for Competition and Consumer Protection (hereafter, UOKiK) found that the agreement between Roche Polska Sp. z o.o. (hereafter, Roche) and Hand-Prod Sp.
Marcin Kolasiński
doaj
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
New Procedural Notices of the Czech Office for the Protection of Competition: Leniency, Settlement, and Alternative Problem Resolution [PDF]
Yearbook of Antitrust and Regulatory Studies, 2015 In connection with the 2012 amendment of the Czech Act on the Protection of Competition (hereafter, APC), reported in YARS last year1, the Czech Office for the Protection of Competition (hereafter, Office) issued three new procedural noticesin November ...
Petra Joanna Pipková, Ivo Šimeček
doaj
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source