Results 91 to 100 of about 3,171 (206)

Switching Long‐Term Prophylaxis to Donidalorsen for Hereditary Angioedema: 1‐Year OASISplus Results

Allergy, EarlyView.
This study evaluated the long‐term safety and efficacy of donidalorsen in patients who switched from a long‐term prophylactic treatment (LTP) to donidalorsen with 1‐year outcomes. Patients who switched from LTP to donidalorsen experienced a 67.6% reduction in HAE attack rates over 52 weeks.
Marc A. Riedl, Jonathan A. Bernstein, Joshua S. Jacobs, Timothy Craig, William R. Lumry, H. James Wedner, Aleena Banerji, Selina Gierer, Andrew Smith, Michael E. Manning, Francesca Perego, Laura Bordone, Sabrina Treadwell, Tao Lin, Kenneth B. Newman, Aaron Yarlas, Danny M. Cohn   +16 more
wiley   +1 more source

Probable “Escitalopram induced” angioedema in a patient with hereditary angioedema [PDF]

, 2019
Hereditary angioedema is an autosomal dominant disorder. Considerable rate of mortality determines the importanceof disease. In this paper, a patient with HAE who developed severe facial angioedema after the first dose of an antidepressant prescribed by ...
YıIdız, Eray, Aytekin, Gökhan, Arslan, Şevket, Çalışkaner, Ahmet Zafer, Çölkesen, Fatih   +4 more
core   +1 more source

Unveiling Rare Genetic Variants in DAB2IP: New Insights Into the Pathogenesis of Recurrent Angioedema

Allergy, EarlyView.
Maurizio Margaglione, Maria D'Apolito, Rosa Santacroce, Giorgia Cordisco, Francesco Arcoleo, Tiziana De Pasquale, Ilaria Puxeddu, Andrea Zanichelli, Mauro Cancian   +8 more
wiley   +1 more source

Impact of Oral Sebetralstat on Anxiety Associated With Hereditary Angioedema Attacks

Clinical &Experimental Allergy, EarlyView.
In the phase 3 KONFIDENT trial of oral sebetralstat for on‐demand treatment of hereditary angioedema attacks, many attacks induced moderate‐to‐extreme anxiety. Sebetralstat reduced anxiety versus placebo; time to reductions agreed with trial endpoints, such as time to beginning of symptom relief.
Timothy Craig, Emel Aygören‐Pürsün, Jonathan A. Bernstein, Paula J. Busse, Teresa Caballero, Danny M. Cohn, Mar Guilarte, Henriette Farkas, Douglas H. Jones, Sorena Kiani‐Alikhan, Michael E. Manning, Marcus Maurer, Marc A. Riedl, Sinisa Savic, H. James Wedner, Patrick F. K. Yong, Andrea Zanichelli, Sally van Kooten, Matthew Iverson, Erik Hansen, James Hao, Michael D. Smith, Christopher M. Yea, Paul K. Audhya, William R. Lumry   +24 more
wiley   +1 more source

Hereditary angioedema: how to approach it at the emergency department?

Einstein (São Paulo)
Angioedema attacks are common causes of emergency care, and due to the potential for severity, it is important that professionals who work in these services know their causes and management.
Faradiba Sarquis Serpa, Eli Mansour, Marcelo Vivolo Aun, Pedro Giavina-Bianchi, Herberto José Chong Neto, Luisa Karla Arruda, Regis Albuquerque Campos, Antônio Abílio Motta, Eliana Toledo, Anete Sevciovic Grumach, Solange Oliveira Rodrigues Valle   +10 more
doaj   +2 more sources

Management of acute attacks of hereditary angioedema: role of ecallantide

, 2015
Hannah Duffey,1 Rafael Firszt1,2 1Department of Pediatrics, 2Division of Allergy, Immunology and Rheumatology, University of Utah, Salt Lake City, UT, USA Abstract: Hereditary angioedema (HAE) is characterized as an episodic swelling disorder with ...
Firszt R, Duffey H
core  

Normalization of C1 Inhibitor in a Patient with Hereditary Angioedema [PDF]

Hereditary angioedema is a potentially life-threatening autosomal dominant condition, causing attacks of angioedema due to failure to regulate bradykinin. Nearly all cases of hereditary angioedema are caused by mutations in the gene encoding C1 inhibitor,
Sharif, Khalid, Kelly, Dominic, Mac Lochlainn, Dylan J., Dhalla, Fatima, Peters, Nicholas E.; id_orcid, Gupte, Girish L., Patel, Smita Y., Jain, Rashmi, Howarth , Lucy   +8 more
core   +1 more source

Berotralstat and Health‐Related Quality of Life in Hereditary Angioedema: Pooled Analysis of the APeX‐2 and APeX‐J Trials

Clinical &Experimental Allergy, EarlyView.
Pooled analysis of the phase 3 APeX‐2 and APeX‐J trials evaluated the impact of berotralstat 150 mg on health‐related quality of life in patients with hereditary angioedema using the Angioedema Quality of Life (AE‐QoL) questionnaire. Berotralstat significantly improved AE‐QoL total and domain scores for daily functioning and fears/shame versus placebo ...
Teresa Caballero, Sorena Kiani‐Alikhan, Douglas T. Johnston, Aolin Wang, Lorena Lopez‐Gonzalez, Zheng‐Yi Zhou, Fan Yang, Hannah H. Kim, Sandra Nestler‐Parr, Dianne Tomita, Patrick Gillard, Tamar Kinaciyan   +11 more
wiley   +1 more source

Epidemiology of Non-hereditary Angioedema

, 2012
The prevalence of non-hereditary angioedema was investigated in a general population sample (n¿=¿7,931) and in a sample of Danish patients (n¿=¿7,433) tested for deficiency of functional complement C1 esterase inhibitor protein (functional C1 INH).
Attermann, Jørn, Linneberg, Allan, Madsen, Flemming   +2 more
core   +1 more source

Inhibiting plasma kallikrein for hereditary angioedema prophylaxis [PDF]

, 2017
BACKGROUND Hereditary angioedema with C1 inhibitor deficiency is characterized by recurrent, unpredictable swelling episodes caused by uncontrolled plasma kallikrein generation and excessive bradykinin release resulting from cleavage of high-molecular ...
Joseph C. Biedenkapp, Paula Busse, Soo, C., Lockey, R., Tenhoor, C., Davis-Lorton, M., Ryan Iarrobino, Faucette, R., Ryan Faucette, Chris Stevens, Iarrobino, R., William Lumry, Riedl, M., H.J.; Jacobs, Aleena Banerji, Jonathan A. Bernstein, Daniel J. Sexton, Ahmad Al-Ghazawi, Carolyn Soo, Timothy Craig, Richard Lockey, Cicardi, M., Al-Ghazawi, A., Sexton, D. J., J. Gordon Still, Craig, T., Shennak, M., Bernstein, J. A., Yung Chyung, Li, H. H., Mark Davis-Lorton, Marco Cicardi, Still, J. G., Joshua Jacobs, Kenniston, J. A., Burt Adelman, Banerji, A., H. Henry Li, Lumry, W., Baker, J., Robert Mensah, Marc Riedl, Stevens, C., Kushner, H., James Baker, Busse, P., Adelman, B., Chyung, Y., Biedenkapp, J. C., Wedner, H. J., Henry J. Wedner, Mensah, R., Jon A. Kenniston, Harvey Kushner, Mustafa Shennak, Christopher TenHoor   +55 more
core   +1 more source