Results 21 to 30 of about 197,953 (330)

Comorbidities in hereditary angioedema—A population‐based cohort study

Clinical and Translational Allergy, 2022
Background In hereditary angioedema (HAE), low levels (type 1) or defect in function (type 2) of the serine‐protease inhibitor C1 Inhibitor protein results in activation of the classical pathway of the complement system as well as the contact system ...
Linda Sundler Björkman, B. Persson, D. Aronsson, L. Skattum, P. Nordenfelt, A. Egesten   +5 more
semanticscholar   +1 more source

Hereditary angioedema: approaches to diagnosis and treatment, analysis of a clinical family case

Медицинский совет, 2021
Hereditary angioedema belongs to the group of rare, orphan, genetically determined defects that represent a significant medical and social problem due to the pronounced impact on the quality of life and potential mortality, as well as the emerging ...
O. V. Skorohodkina, A. V. Luntsov, A. A. Vasileva, O. A. Bareycheva   +3 more
doaj   +1 more source

Pharmacological suppression of the kallikrein kinin system with KVD900: An orally available plasma kallikrein inhibitor for the on‐demand treatment of hereditary angioedema

Clinical and Experimental Allergy, 2022
Hereditary angioedema (HAE) is a rare genetic disease that leads to recurrent episodes of swelling and pain caused by uncontrolled plasma kallikrein (PKa) activity.
Edward J. Duckworth, Nivetha Murugesan, Lily Li, Louise J. Rushbrooke, Daniel K Lee, G. M. De Donatis, A. Maetzel, C. Yea, S. Hampton, E. Feener   +9 more
semanticscholar   +1 more source

Hereditary angioedema: a disease seldom diagnosed by pediatricians

Jornal de Pediatria, 2021
Objectives: To describe the hereditary angioedema to improve awareness of this condition and reduce diagnostic delay. Data sources: Relevant articles in the MEDLINE database through PubMed.
Régis de Albuquerque Campos, Solange Oliveira Rodrigues Valle, Eliana Cristina Toledo   +2 more
doaj   +1 more source

A Mechanism for Hereditary Angioedema Caused by a Lysine311 to Glutamic Acid Substitution in Plasminogen.

Blood, 2022
Patients with hereditary angioedema (HAE) experience episodes of bradykinin-induced swelling of skin and mucosal membranes. The most common cause is reduced plasma activity of C1-inhibitor, the main regulator of the proteases plasma kallikrein (PKa) and ...
S. Dickeson, Sunil Kumar, Mao-fu Sun, B. Mohammed, Dennis R. Phillips, J. Whisstock, Adam J. Quek, E. Feener, R. Law, D. Gailani   +9 more
semanticscholar   +1 more source

Angioedema. Interdisciplinary diagnostic and therapeutic recommendations of the Polish Dermatological Society (PTD) and Polish Society of Allergology (PTA)

Przegląd Dermatologiczny, 2020
Angioedema is a non-inflammatory edema of the subcutaneous tissue and/or mucosal membranes. It commonly coexists with urticaria and is considered a deep form of urticaria.
Roman Nowicki, Elżbieta Grubska-Suchanek, Grzegorz Porębski, Marek L. Kowalski, Karina Jahnz-Różyk, Tomasz Matuszewski, Lidia Rudnicka, Marek Kulus, Wioletta Barańska-Rybak, Rafał Czajkowski, Zbigniew Doniec, Cezary Kowalewski, Beata Kręcisz, Magdalena Lange, Joanna Narbutt, Małgorzata Olszewska, Małgorzata Sokołowska-Wojdyło, Aneta Szczerkowska-Dobosz, Radosław Śpiewak, Magdalena Trzeciak, Aleksandra Wilkowska   +20 more
doaj   +1 more source

Hereditary angioedema is associated with an increased risk of venous thromboembolism

Journal of Thrombosis and Haemostasis, 2022
To the Editor, Hereditary angioedema (HAE) is a congenital disorder primarily caused by mutations in the SERPING1 gene that lead to reduced plasma levels or functional activity of C1inhibitor (C1INH).1 A rare subtype of HAE with normal C1INH (HAE– nC1INH)
S. Grover, Linda Sundler Björkman, A. Egesten, S. Moll, N. Mackman   +4 more
semanticscholar   +1 more source

Outcomes of long term treatments of type I hereditary angioedema in a Turkish family [PDF]

Anais Brasileiros de Dermatologia, 2017
: Background: Hereditary angioedema is a rare autosomal dominantly inherited immunodeficiency disorder characterized by potentially life-threatening angioedema attacks.
Gulsen Akoglu, Belgin Kesim, Gokhan Yildiz, Ahmet Metin   +3 more
doaj   +2 more sources

Treatment of hereditary angioedema—single or multiple pathways to the rescue

Frontiers in Allergy, 2022
Hereditary angioedema (HAE) is a rare disease caused by mutations in the SERPING1 gene. This results in deficient or dysfunctional C1 esterase inhibitor (C1-INH) and affects multiple proteases involved in the complement, contact-system, coagulation, and ...
A. Valerieva, H. Longhurst
semanticscholar   +1 more source

Hereditary Angioedema

Applied Radiology, 2022
multicenter, randomized, double-blind, placebo-controlled, parallel group study evaluated the efficacy of berotralstat for the prevention of angioedema attacks in patients ≥ 12 years of age with type I and II HAE. 77, 78 The study enrolled 121 adults and
Luke M Lammers, R. Towbin, C. Schaefer, A. Towbin   +3 more
semanticscholar   +1 more source