Results 181 to 190 of about 427,242 (236)

Genetic and Clinical Spectrum of Hereditary Transthyretin Amyloidosis in Brazil. [PDF]

J Peripher Nerv Syst
Maximiano-Alves G, Lavigne-Moreira C, Simões MV, Galvão AJP, Valicelli FH, Coneglian FS, Vegezzi E, Garibaldi PMM, Tomaselli PJ, Cortese A, Marques W.   +10 more
europepmc   +1 more source

Perioperative replacement therapy for a patient with hereditary factor V deficiency.

, 1990
Shinya Ueno, Yasuhiro Umeki, Hiroko Tsuda, Shosuke Takahashi, Junichi Yoshitake   +4 more
openalex   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Advances in research on congenital and hereditary intestinal diseases: From molecular mechanisms to precision medicine. [PDF]

Intractable Rare Dis Res
Yang L, Wang Y, Yuan L, Tang W.
europepmc   +1 more source

Identification of risk factors affecting bone formation in gradual ulnar lengthening in children with hereditary multiple exostoses

, 2019
Yuchan Li, Bingqiang Han, Jingyan Tang, Mu Chen, Zhigang Wang   +4 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Abstracts of the 14th C1-inhibitor Deficiency and Angioedema Workshop. [PDF]

Allergy Asthma Clin Immunol
europepmc   +1 more source

Allogeneic Hematopoietic Stem Cell Transplantation as a Therapeutic Approach for Hereditary Diseases. [PDF]

Biomedicines
Nagieva S, Smirnikhina S.
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Processed Transcript Insertion as a Novel Germline Mutational Mechanism in <i>BRCA1</i>-Associated Hereditary Breast Cancer. [PDF]

Cancers (Basel)
Bozsik A, Butz H, Grolmusz VK, Nagy P, Pócza T, Tóth E, Csernák E, Patócs A, Papp J.   +8 more
europepmc   +1 more source