Results 61 to 70 of about 15,219 (276)

Rare autosomal dominant hereditary hemochromatosis associated with SLC40A1 gene: ferroportin disease or type 4 hereditary hemochromatosis? [PDF]

, 2019
Ferroportin (FPN1), encoded by the SLC40A1 gene, is the unique cellular iron exporter identified in mammals. FPN1 transfers iron from the intestine and macrophages into the bloodstream. This function is negatively regulated by hepcidin.
Faustino, Paula, Fleming, Rita, Lavinha, João, Machado, Miguel P., Mendonça, Joana, Simão, Rita, Tavares, Wilson, Vieira, Luís   +7 more
core  

Multi‐Center, Multi‐Vendor Validation of Simultaneous MRI‐Based Proton Density Fat Fraction and R2* Mapping Using a Combined Proton Density Fat Fraction‐R2* Phantom

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Fat and iron deposition confound measurements of R2* and proton density fat fraction (PDFF), respectively, yet their combined impact on reproducibility is poorly understood. Purpose To evaluate the multi‐center, multi‐vendor reproducibility of PDFF and R2* quantification using a PDFF‐R2* phantom. Study Type Prospective multi‐center,
Jitka Starekova, David Rutkowski, Won C. Bae, Hung Do, Ananth J. Madhuranthakam, Vadim Malis, Sheng Qing Lin, Suraj Serai, Takeshi Yokoo, Scott B. Reeder, Jean H. Brittain, Diego Hernando   +11 more
wiley   +1 more source

Prevalence of iron deficiency in 62,685 women of seven race/ethnicity groups: The HEIRS Study. [PDF]

, 2020
BackgroundFew cross-sectional studies report iron deficiency (ID) prevalence in women of different race/ethnicity and ages in US or Canada.Materials and methodsWe evaluated screening observations on women who participated between 2001-2003 in a cross ...
Acton, Ronald T, Adams, Paul C, Barton, James C, Eckfeldt, John H, Gordeuk, Victor R, Harris, Emily L, Harrison, Helen, McLaren, Christine E, McLaren, Gordon D, Reboussin, David M, Wiener, Howard H   +10 more
core  

The SOD2 C47T polymorphism influences NAFLD fibrosis severity: evidence from case-control and intra-familial allele association studies. [PDF]

, 2011
AIMS: Non-alcoholic fatty liver disease (NAFLD) is a complex disease trait where genetic variations and environment interact to determine disease progression.
Al Serri, Ahmad, Anstee, Quentin M, Daly, Ann K, Day, Christopher P, Dongiovanni, Paola, Fargion, Silvia, Fracanzani, Anna, Leathart, Julian B S, Nobili, Valerio, Patch, Julia, Valenti, Luca   +10 more
core   +1 more source

Twin-Distance-Hereditary Digraphs [PDF]

arXiv, 2021
We investigate structural and algorithmic advantages of a directed version of the well-researched class of distance-hereditary graphs. Since the previously defined distance-hereditary digraphs do not permit a recursive structure, we define directed twin-distance-hereditary graphs, which can be constructed by several twin and pendant vertex operations ...
arxiv  

Hereditary Substitution for the λΔ-Calculus [PDF]

EPTCS 127, 2013, pp. 45-65, 2013
Hereditary substitution is a form of type-bounded iterated substitution, first made explicit by Watkins et al. and Adams in order to show normalization of proof terms for various constructive logics. This paper is the first to apply hereditary substitution to show normalization of a type theory corresponding to a non-constructive logic, namely the ...
arxiv   +1 more source

Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plamsa membrane [PDF]

, 2008
Hemochromatosis type 2 gene (HFE2) is highly expressed in skeletal muscle and liver hepatocytes. Its encoded protein, hemojuvelin (HJV), is a co-receptor for the bone morphogenetic proteins 2 and 4 (BMP2 and BMP4) and enhances the BMP-induced hepcidin ...
Altschuler, Babitt, Babitt, Bowman, Camaschella, Chadda, Cole, De Gobbi, Feng, Hammond, Hentze, Huang, Keeling, Krijt, Kuninger, Lin, Lin, Lin, Macia, Matsunaga, Mawdsley, Mayor, Mayor, Meyerhardt, Nemeth, Nichols, Niederkofler, Niederkofler, Oldekamp, Orlandi, Papanikolaou, Park, Pigeon, Roy, Samad, Schmidt, Schmidtmer, Silvestri, Silvestri, Subtil, ten Dijke, Thomas, VanSlyke, Vielmetter, Wang, Wilson, Wilson, Wilson, Yang, Zhang, Zhang, Zhang   +51 more
core   +3 more sources

Anemia and retinopathy of prematurity: A narrative review

Pediatric Investigation, EarlyView.
Anemia in infants who are at greatest risk of developing severe retinopathy of prematurity is almost universal. There is plausible evidence in the literature correlating anemia with severe ROP. However, the relationship is complex, and further study is needed to better understand the potential molecular mechanisms for anemia‐associated ROP.
Minali Prasad, David Dombrovsky, Stephen P. Christiansen, Ellen C. Ingolfsland   +3 more
wiley   +1 more source

The Role of Magnesium in Liver Cirrhosis

Portal Hypertension &Cirrhosis, EarlyView.
Magnesium is a vital mineral involved in over 300 enzymatic reactions, crucial for physiological functions. Its deficiency, common in liver cirrhosis patients, correlates with poor outcomes by affecting inflammation, oxidative stress, fibrosis, and immunity. This review explores magnesium's role in cirrhosis and its interaction with disease mechanisms.
Weiye Zeng, Xudan Wang, He Qi, Hongtao Tang, Xun Qi   +4 more
wiley   +1 more source

HFE-associated hereditary hemochromatosis [PDF]

Genetics in Medicine, 2009
In populations of northern European descent, the p.C282Y mutation in the HFE gene is highly prevalent, and HFE-associated hereditary hemochromatosis is the most common type of inherited iron overload disorder. Inappropriate low secretion of hepcidin, which negatively regulates iron absorption, is postulated to be the mechanism for iron overload in this
Jacob Alexander, Kris V. Kowdley, Kris V. Kowdley   +2 more
openaire   +2 more sources