Use of family history taking for hereditary neoplastic syndromes screening in primary health care: A systematic review protocol. [PDF]
PLoS ONE, 2022 BackgroundAlthough most neoplasms result from complex interactions between the individual's genome and the environment, a percentage of cases is particularly due to inherited alterations that confer a greater predisposition to the development of tumors ...
Raphael Manhães Pessanha +3 more
doaj +6 more sources
Risk for Hereditary Neoplastic Syndromes in Women with Mismatch Repair-Proficient Endometrial Cancer [PDF]
Genes, 2023 Endometrial cancer (EC) is a prevalent malignancy in women, and those who are proficient in the DNA mismatch repair (pMMR) pathway may have a family history (FH) that meets the criteria for a hereditary neoplastic condition (HNS). This study aimed to estimate the risk of HNS in women with pMMR endometrial tumors by analyzing their FH.
Jennifer Thalita Targino dos Santos +6 more
openaire +3 more sources
Diagnostics of hereditary cancer syndromes by ngs. A database creation experience [PDF]
Клиническая практика, 2021 Background: More than 500 thousand new cases of malignant neoplasms are registered annually in the Russian Federation, of which more than 50 thousand new cases are due to hereditary forms.
Ivan S. Abramov +8 more
doaj +1 more source
Lynch-like Syndrome and its Molecular Approaches: A Brief Report and Literature Review [PDF]
Middle East Journal of Cancer, 2023 Lynch syndrome (LS) predisposes individuals to early-onset colorectal and other Lynch-associated cancer. This disorder is an autosomal dominant genetic disturbance caused by germline mutations in one of the mismatch repair genes.
Zeinab Abdollahi +3 more
doaj +1 more source
Hereditary melanoma: a five-year study of Brazilian patients in a cancer referral center - phenotypic characteristics of probands and pathological features of primary tumors [PDF]
Anais Brasileiros de Dermatologia, 2018 : BACKGROUND: Approximately five to 10% of all melanomas occur in families with hereditary predisposition and the main high-risk melanoma susceptibility gene is the CDKN2A.
Bianca Costa Soares de Sá +4 more
doaj +2 more sources
Management of Patients with Hereditary Colorectal Cancer Syndromes
GE: Portuguese Journal of Gastroenterology, 2015 Colorectal cancer (CRC) is one of the most important causes of death in the world. Hereditary CRC is found in 5–10% of CRC patients. In this review, we will focus on the major forms of hereditary CRC and their management according to the most recent ...
Catarina Brandão, Jorge Lage
doaj +1 more source
Fibroblast growth factor receptor signaling in hereditary and neoplastic disease: biologic and clinical implications. [PDF]
, 2015 Fibroblast growth factors (FGFs) and their receptors (FGFRs) are transmembrane growth factor receptors with wide tissue distribution. FGF/FGFR signaling is involved in neoplastic behavior and also development, differentiation, growth, and survival.
Helsten, Teresa +2 more
core +2 more sources
Alʹmanah Kliničeskoj Mediciny, 2018 Up to 10% of cases of sporadic colorectal cancer are considered to be related to hereditary genetic factors. The rates of colorectal cancer related to already identified genetic factors is about 5%.
D. Yu. Pikunov +2 more
doaj +1 more source
Cancer Predisposition Syndromes and Medulloblastoma in the Molecular Era
Frontiers in Oncology, 2020 Medulloblastoma is the most common malignant brain tumor in children. In addition to sporadic cases, medulloblastoma may occur in association with cancer predisposition syndromes.
Roberto Carta +18 more
doaj +1 more source
Cutaneous Expression of Familial Cancer Syndromes
Acta Dermato-Venereologica, 2021 Genodermatoses are inherited syndromes with cutaneous manifestations. Some genodermatoses are associated with malignancy of internal organs and tissues.
Anne-Johanne Andersen +3 more
doaj +1 more source